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테트라싸이클린을 함유한 기능성 키토산 차단막의 제조

Other Titles
 Preparation of Functional Chitosan Membranes Containing Tetracycline 
Authors
 장기성  ;  이수복  ;  이범훈  ;  민우기  ;  김원근  ;  정용식  ;  최성호  ;  이용근 
Citation
 Journal of the Korean Society of Textile Engineers and Chemists (한국섬유공학회지), Vol.42(3) : 155-160, 2005 
Journal Title
Journal of the Korean Society of Textile Engineers and Chemists(한국섬유공학회지)
ISSN
 1225-1089 
Issue Date
2005
Abstract
Chitosan, a poly-saccharide, has been widely studied as bone substitution and membrane material in periodontology as well as orthopedic application. Tetracycline has been considered for use in the treatment of chronic periodontal disease and gingivitis. The aim of the present study is to make a comparative study of two ways for fabricating chitosan membrane containing tetracycline and achieve sustained and controlled local delivery of the antibiotic to the diseased tissue. Two types of membranes, non-woven and sponge, were fabricated with various concentration of tetracycline. The tensile strength of the chitosan fiber was tested by Vibrodyn and the membranes were tested on a universal test machine. Streptococcus mutans were employed to examine the antibacterial properties of the membranes. Body-safety of the membranes were determined by the Salmonella Mutagenicity test, the micronucleus test, the acute oral toxicity test, and skin patch test. The sponge type chitosan membrane was found to have an excellent tensile strength.
Files in This Item:
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Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Dental Biomaterials and Bioengineering (치과생체재료공학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Yong Keun(이용근)
Choi, Seong Ho(최성호) ORCID logo https://orcid.org/0000-0001-6704-6124
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/151301
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