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Different role of functional domains of hTR in DNA binding to telomere and telomerase reconstruction

Authors
 M. Yeo  ;  S.Y. Rha  ;  H.C. Jeung  ;  X.H. Shen  ;  S.H. Yang  ;  S.W. An  ;  J.K. Roh  ;  H.C. Chung 
Citation
 FEBS Letters, Vol.579(1) : 127-132, 2005 
Journal Title
 FEBS Letters 
ISSN
 0014-5793 
Issue Date
2005
Abstract
Even if template sequence of hTR played an essential role in telomere binding, a 326 nucleotide fragment of hTR containing template, pseudoknot, and CR4–5 domains is critical for both binding with telomeric DNA and reconstitution of telomerase activity. A functional study with antisense oligonucleotides suggested that targeted disruption of the template region efficiently abrogated both telomeric DNA binding and telomerase activity, whereas disruption of the CR4–5 region induced only loss of telomerase activity. hTR interacts with telomeric DNA via structural region composed of the template, pseudoknot, and CR4–5 domains, however, each structural domain plays a distinct role in telomere binding and telomerase activity reconstitution.
Files in This Item:
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DOI
10.1016/j.febslet.2004.11.058
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
1. Journal Papers (연구논문) > 5. Research Institutes (연구소) > Cancer Metastasis Research Center (암전이연구센터)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원)
Yonsei Authors
노재경(Roh, Jae Kyung)
라선영(Rha, Sun Young) ORCID logo https://orcid.org/0000-0002-2512-4531
심웅호(Shen, Xiong Hu)
안성환(An, Sung Whan)
양상화(Yang, Sang Hwa)
여말희(Yeo, Marie)
정현철(Chung, Hyun Cheol) ORCID logo https://orcid.org/0000-0002-0920-9471
정희철(Jeung, Hei Cheul)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/151234
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