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Different role of functional domains of hTR in DNA binding to telomere and telomerase reconstruction

Authors
 M. Yeo  ;  S.Y. Rha  ;  H.C. Jeung  ;  X.H. Shen  ;  S.H. Yang  ;  S.W. An  ;  J.K. Roh  ;  H.C. Chung 
Citation
 FEBS Letters, Vol.579(1) : 127-132, 2005 
Journal Title
 FEBS Letters 
ISSN
 0014-5793 
Issue Date
2005
Abstract
Even if template sequence of hTR played an essential role in telomere binding, a 326 nucleotide fragment of hTR containing template, pseudoknot, and CR4–5 domains is critical for both binding with telomeric DNA and reconstitution of telomerase activity. A functional study with antisense oligonucleotides suggested that targeted disruption of the template region efficiently abrogated both telomeric DNA binding and telomerase activity, whereas disruption of the CR4–5 region induced only loss of telomerase activity. hTR interacts with telomeric DNA via structural region composed of the template, pseudoknot, and CR4–5 domains, however, each structural domain plays a distinct role in telomere binding and telomerase activity reconstitution.
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DOI
10.1016/j.febslet.2004.11.058
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Cancer Metastasis Research Center (암전이연구센터) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Roh, Jae Kyung(노재경)
Rha, Sun Young(라선영) ORCID logo https://orcid.org/0000-0002-2512-4531
Shen, Xiong Hu(심웅호)
An, Sung Whan(안성환)
Yang, Sang Hwa(양상화)
Yeo, Marie(여말희)
Chung, Hyun Cheol(정현철) ORCID logo https://orcid.org/0000-0002-0920-9471
Jeung, Hei Cheul(정희철) ORCID logo https://orcid.org/0000-0003-0952-3679
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/151234
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