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Formation of spacing pattern and morphogenesis of chick feather buds is regulated by cytoskeletal structures

Authors
 Jae-Young Kim  ;  Sung-Won Cho  ;  Wu-Chul Song  ;  Min-Jung Lee  ;  Jinglei Cai  ;  Seung-Ho Ohk  ;  Hee-Kyung Song  ;  Alexander Degan  ;  Han-Sung Jung 
Citation
 DIFFERENTIATION, Vol.73(5) : 240-248, 2005 
Journal Title
 DIFFERENTIATION 
ISSN
 0301-4681 
Issue Date
2005
MeSH
Animals ; Bone Morphogenetic Protein 4 ; Bone Morphogenetic Proteins/biosynthesis ; Bone Morphogenetic Proteins/genetics ; Chick Embryo ; Cytochalasin D/pharmacology ; Cytoskeleton/drug effects ; Cytoskeleton/physiology* ; DNA-Binding Proteins/biosynthesis ; DNA-Binding Proteins/genetics ; Dose-Response Relationship, Drug ; Feathers/embryology* ; Homeodomain Proteins ; Mesoderm/physiology ; Nocodazole/pharmacology ; Signal Transduction/physiology
Keywords
cytochalasin D ; mesenchymal condensation ; axis formation ; spacing pattern ; feather bud development
Abstract
Chick feather buds develop sequentially in a hexagonal array. Each feather bud develops with anterior posterior polarity, which is thought to develop in response to signals derived from specialized regions of mesenchymal condensation and epithelial thickening. These developmental processes are performed by cellular mechanisms, such as cell proliferation and migration, which occur during chick feather bud development. In order to understand the mechanisms regulating the formation of mesenchymal condensation and their role in feather bud development, we explanted chick dorsal skin at stage HH29+ with cytochalasin D, which inhibits cytoskeletal formation. We show that the aggregation of mesenchymal cells can be prevented by cytochalasin D treatment in a concentration-dependent manner. Subsequently, cytochalasin D disrupts the spacing pattern and inhibits feather bud axis formation as well. In addition, expression patterns of Bmp-4 and Msx-2, key molecules for early feather bud development, were disturbed by cytochalasin D treatment. Our results fully indicate that both the cytoskeletal structure and cell activity via gene regulation are of fundamental importance in mesenchymal condensation leading to proper morphogenesis of feather bud and spacing pattern formation.
Full Text
http://www.sciencedirect.com/science/article/pii/S0301468109603352
DOI
10.1111/j.1432-0436.2005.00020.x
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jae Young(김재영)
Song, Wu Chul(송우철)
Lee, Min Jung(이민정)
Jung, Han Sung(정한성) ORCID logo https://orcid.org/0000-0003-2795-531X
Cho, Sung Won(조성원) ORCID logo https://orcid.org/0000-0001-7505-9769
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/151014
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