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Characteristic tissue interaction of the diastema region in mice

Other Titles
 Characteristic tissue interaction of the diastema region in mice 
 Hitoshi Yamamoto  ;  Sung-Won Cho  ;  Soo-Jin Song  ;  Heui-Jung Hwang  ;  Min-Jung Lee  ;  Jae-Young Kim  ;  Han-Sung Jung 
 Archives of Oral Biology, Vol.50(2) : 189-198, 2005 
Journal Title
 Archives of Oral Biology 
Issue Date
Rodents have a toothless diastema between the incisor and the first molar, which may contain rudimentary tooth germs. In the lower diastema region of mice at E13, the rudimentary tooth germs, which developed into the bud stage before its removal by apoptosis, was found. The immunoreactivity to tenascin was observed in the condensed mesenchyme around the normal tooth bud and was detected in only the basement membrane in the diastema bud. This result shows that the relationship between mesenchymal condensation and tooth development. The similar patterns of Msx-1 and Msx-2 expression between the tooth bud and the diastema bud show that the diastema bud may have some other genetic mechanism in the developmental arrest of the rudimentary tooth germs rather than the Msx-1 and Msx-2 expression. Strikingly, the induction of the tooth formation was possible using tissue recombination between the oral epithelium of the diastema bud and the dental mesenchyme of the molar tooth bud, which indicates the potential capability of the diastema in the tooth formation. In conclusion, it is suggested that the condensed mesenchyme may be the key to tooth development.
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1. Journal Papers (연구논문) > 2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실)
1. Journal Papers (연구논문) > 5. Research Institutes (연구소) > Oral Science Research Center (구강과학연구소)
Yonsei Authors
김재영(Kim, Jae Young)
송수진(Song, Soo Jin)
이민정(Lee, Min Jung)
정한성(Jung, Han Sung)
조성원(Cho, Sung Won) ORCID logo https://orcid.org/0000-0001-7505-9769
황희정(Hwang, Heui Jung)
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