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Mirtazapine 치료가 여자 우울증 환자의 해마 대사물질에 미치는 영향

Other Titles
 Effects of Mirtazapine on Hippocampal Metabolites of Female Patients with Major Depression 
Authors
 남윤영  ;  김찬형  ;  이승구  ;  장동표  ;  김재진  ;  김지웅  ;  김선일  ;  이홍식 
Citation
 Korean Journal of Psychopharmacology (대한정신약물학회지), Vol.16(2) : 146-155, 2005 
Journal Title
 Korean Journal of Psychopharmacology (대한정신약물학회지) 
ISSN
 1017-5717 
Issue Date
2005
MeSH
Major depression ; Mirtazapine ; Magnetic resonance spectroscopy ; Choline ; Hippocampus
Keywords
Major depression ; Mirtazapine ; Magnetic resonance spectroscopy ; Choline ; Hippocampus
Abstract
Objective:Recent studies suggested that the neurotrophic effects might be a major therapeutic mechanism of antidepressants. However, these effects have not been confirmed yet in depressed patients. We investigated whether mirtazapine treatment has the neurotrophic effects in depressed patient by using 1^H-MRS and explored the relationship between these effects and clinical improvements and neuropsychological functions. Methods: Fourteen female, right-handed patients with major depressive disorder and 12 healthy controls participated in the study. Before the treatment with mirtazapine, we measured severity of illness, neuropsychological functions, and the levels of NAA, Cho and Cr in both hippocampi using 1^H-MRS in the depressed subjects. After the treatment with mirtazapine for 6 weeks, we repeated the measures of the pretreatment condition in the depressed subjects. We also measured variables of severity of illness and hippocampal metabolites with 1^H-MRS in the control group. Results:There were no significant differences in NAA/Cr, Cho/Cr, and Cho/NAA between the depressed subjects and the control group. However, after the treatment with mirtazapine, there were significant improvements in severity of illness, immediate memory, and delayed memory. The posttreatment ratio of the total hippocampal Cho/Cr was significantly lowered than the ratio of the pretreatment Cho/Cr. However, the percent changes of the hippocampal Cho/Cr from the pretreatment Cho/Cr ratio were not correlated with the changes of severity of illness or neuropsychological functions from the pretreatment condition. Conclusions:These findings indicate that mirtazapine may reduce the level of choline metabolites by stabilizing the effect on the cholinergic neurons, reducing turnover or metabolism of neuronal membranes, or modulating the neuroendocrine systems in the depressed patients. However, this effect is not necessarily related to clinical improvements. Further studies on the therapeutic action of mirtazapine are needed.
Files in This Item:
T200500622.pdf Download
DOI
OAK-2005-03900
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jae Jin(김재진) ORCID logo https://orcid.org/0000-0002-1395-4562
Kim, Ji Woong(김지웅)
Kim, Chan Hyung(김찬형)
Nam, Yoon Young(남윤영)
Lee, Seung Koo(이승구) ORCID logo https://orcid.org/0000-0001-5646-4072
Lee, Hong Shick(이홍식)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/150468
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