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여성 우울증 환자의 해마 대사물질의 임상적 의의

Other Titles
 The Clinical Meanings of the Hippocampal Metabolites of Female Patients with Major Depressive Disorder 
Authors
 남윤영  ;  김찬형  ;  이승구  ;  장동표  ;  김재진  ;  전우택  ;  신의진  ;  이홍식 
Citation
 Korean Journal of Psychopharmacology (대한정신약물학회지), Vol.16(1) : 60-68, 2005 
Journal Title
 Korean Journal of Psychopharmacology (대한정신약물학회지) 
ISSN
 1017-5717 
Issue Date
2005
MeSH
Major depressive disorder ; Hippocampus ; Magnetic resonance spectroscopy
Keywords
Major depressive disorder ; Hippocampus ; Magnetic resonance spectroscopy
Abstract
Objective: Stress and elevated levels of glucocorticoids in patients with major depressive disorder (MDD) have been hypothesized to be associated with damage to the hippocampus. However the relationship between depression and hippocampal structure is unconfirmed. We investigated whether the chemical changes will occurr in the hippocampus of patients with MDD by using 1H-magnetic resonance spectroscopy (MRS) and explored the clinical meanings of hippocampal metabolites. Methods: Fourteen female, right-handed patients with major depressive disorder and 12 healthy controls (age, sex, education and their dextrality matched) were included. We measured variables of time course of illness, severity of illness, levels of NAA, Cho and Cr in both hippocampus using 1 H-MRS. In addition, we performed neuropsychological tests in depressed subjects. Results: There were no significant difference in the NAA/Cr, Cho/Cr, Cho/NAA between depressed and control subjects. In depressed subjects, significant negative correlations were observed between hippocampal NAA/Cr and duration of illness, duration of unmedication, severity of illness, respectively. Right hippocampal NAA/Cr was correlated with RCFT scores. Conclusion: These findings indicate damage to the hippocampus may not be a common feature in all depressed patients. However the results suggest that the illness burden and past treatment may influence hippocampal neurons and neuronal network in patients with MDD. Also, chemical changes in hippocampus may be associated with severity of illness and memory function.
Files in This Item:
T200500620.pdf Download
DOI
OAK-2005-03890
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Medical Education (의학교육학과) > 1. Journal Papers
Yonsei Authors
Kim, Jae Jin(김재진) ORCID logo https://orcid.org/0000-0002-1395-4562
Kim, Chan Hyung(김찬형)
Nam, Yoon Young(남윤영)
Shin, Yee Jin(신의진) ORCID logo https://orcid.org/0000-0001-8573-4342
Lee, Seung Koo(이승구) ORCID logo https://orcid.org/0000-0001-5646-4072
Lee, Hong Shick(이홍식)
Jeon, Woo Taek(전우택) ORCID logo https://orcid.org/0000-0002-9213-6057
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/150457
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