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Induction of cell death by photodynamic therapy with a new synthetic photosensitizer DH-I-180-3 in undifferentiated and differentiated 3T3-L1 cells
DC Field | Value | Language |
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dc.contributor.author | 고시환 | - |
dc.contributor.author | 김세종 | - |
dc.contributor.author | 박전한 | - |
dc.contributor.author | 이원영 | - |
dc.contributor.author | 이재면 | - |
dc.contributor.author | 최윤희 | - |
dc.date.accessioned | 2017-09-30T06:32:20Z | - |
dc.date.available | 2017-09-30T06:32:20Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/150014 | - |
dc.description.abstract | To examine the photodynamic therapy (PDT) effect on adipocytes, we investigated whether PDT using DH-I-180-3, a new synthetic lipophilic photosensitizer, induced cell death of both undifferentiated and differentiated 3T3-L1. 3T3-L1 pre-adipocytes were differentiated into adipocytes in the culture medium containing pantothenate, insulin, dexamethasone, isobutylmethylxanthine, and troglitazone. PDT was applied to both undifferentiated and differentiated 3T3-L1. Photosensitizer uptake in fat cells was determined by measuring its mean fluorescence intensity. DH-I-180-3 mediated effectively PDT-induced cell death of both pre-adipocytes and adipocytes. And the photosensitizer was accumulated more rapidly in 3T3-L1 adipocytes, compared with other cancer cell lines. These results demonstrate that PDT is a potent cell death inducer in pre-adipocytes and adipocytes. Thus, PDT with DH-I-180-3 may be applied for a new therapeutic modality for obesity treatment. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | PDT | - |
dc.subject.MESH | DH-I-180-3 | - |
dc.subject.MESH | Cell death | - |
dc.subject.MESH | Pre-adipocytes | - |
dc.subject.MESH | Adipocytes | - |
dc.title | Induction of cell death by photodynamic therapy with a new synthetic photosensitizer DH-I-180-3 in undifferentiated and differentiated 3T3-L1 cells | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Others | - |
dc.contributor.department | Dept. of Microbiology (미생물학교실) | - |
dc.contributor.department | Dept. of Microbiology (미생물학교실) | - |
dc.contributor.department | Dept. of Microbiology (미생물학교실) | - |
dc.contributor.department | Dept. of Microbiology (미생물학교실) | - |
dc.contributor.department | Dept. of Microbiology (미생물학교실) | - |
dc.contributor.googleauthor | Youn-Hee Choi | - |
dc.contributor.googleauthor | Si-Hwan Ko | - |
dc.contributor.googleauthor | Se Jong Kim | - |
dc.contributor.googleauthor | Won-Young Lee | - |
dc.contributor.googleauthor | Jeon Han Park | - |
dc.contributor.googleauthor | Jae Myun Lee | - |
dc.identifier.doi | 10.1016/j.bbrc.2005.09.151 | - |
dc.contributor.localId | A00125 | - |
dc.contributor.localId | A00603 | - |
dc.contributor.localId | A01641 | - |
dc.contributor.localId | A03003 | - |
dc.contributor.localId | A03071 | - |
dc.contributor.localId | A04145 | - |
dc.relation.journalcode | J00281 | - |
dc.identifier.eissn | 1090-2104 | - |
dc.identifier.pmid | 10.1016/j.bbrc.2005.09.151 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0006291X05021765 | - |
dc.subject.keyword | PDT | - |
dc.subject.keyword | DH-I-180-3 | - |
dc.subject.keyword | Cell death | - |
dc.subject.keyword | Pre-adipocytes | - |
dc.subject.keyword | Adipocytes | - |
dc.contributor.alternativeName | Ko, Si Hwan | - |
dc.contributor.alternativeName | Kim, Se Jong | - |
dc.contributor.alternativeName | Park, Jeon Han | - |
dc.contributor.alternativeName | Lee, Won Young | - |
dc.contributor.alternativeName | Lee, Jae Myun | - |
dc.contributor.alternativeName | Choi, Youn Hee | - |
dc.contributor.affiliatedAuthor | 최윤희 | - |
dc.citation.volume | 337 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 1059 | - |
dc.citation.endPage | 1064 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol.337(4) : 1059-1064, 2005 | - |
dc.date.modified | 2017-05-04 | - |
dc.identifier.rimsid | 42696 | - |
dc.type.rims | ART | - |
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