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Free radicals as triggers of brain edema formation after stroke

Authors
 Ji Hoe Heo  ;  Sang Won Han  ;  Seung Koo Lee 
Citation
 FREE RADICAL BIOLOGY AND MEDICINE, Vol.39(1) : 51-70, 2005 
Journal Title
 FREE RADICAL BIOLOGY AND MEDICINE 
ISSN
 0891-5849 
Issue Date
2005
MeSH
Blood-Brain Barrier/physiopathology ; Brain Edema/diagnosis ; Brain Edema/etiology* ; Brain Edema/therapy ; Cerebral Hemorrhage/physiopathology ; Encephalitis/physiopathology ; Fibrinolytic Agents/therapeutic use ; Free Radicals/adverse effects* ; Humans ; Neuroprotective Agents/therapeutic use ; Stroke/complications* ; Tomography Scanners, X-Ray Computed
Keywords
Brain edema ; Free radicals ; Cerebral infarction ; Ischemia
Abstract
Brain edema is a leading cause of death after stroke. Cytotoxic edema, which is most severe in astrocytes, begins within a few minutes of adenosine triphosphate depletion and reflects the ultimate infarct size. Vasogenic edema is caused by uncontrolled fluid leakage from the blood to the brain parenchyma through a weakened blood–brain barrier (BBB) and contributes to an actual net volume increase of the brain, which often leads to death. Recent research on ischemia-induced injury mechanisms of the microvasculature has led to the disclosure of the mechanisms and cellular pathways leading to BBB breakdown. In addition, the introduction of magnetic resonance imaging to clinical practice has enabled the evaluation of edema severity in stroke patients and differentiation between cytotoxic and vasogenic edema. Free radicals exert their deleterious actions during both cytotoxic and vasogenic edema. They can contribute to BBB disruption directly and can also trigger molecular pathways related to the dysfunction of ion transporters in the cell membrane and those related to increased vascular permeability. The development of effective therapeutic strategies aimed at reducing brain edema based on targeting specific molecular pathways involved may reduce death and disability from stroke.
Full Text
http://www.sciencedirect.com/science/article/pii/S0891584905001929
DOI
10.1016/j.freeradbiomed.2005.03.035
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Seung Koo(이승구) ORCID logo https://orcid.org/0000-0001-5646-4072
Han, Sang Won(한상원)
Heo, Ji Hoe(허지회) ORCID logo https://orcid.org/0000-0001-9898-3321
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/147624
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