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Free radicals as triggers of brain edema formation after stroke

DC FieldValueLanguage
dc.contributor.author이승구-
dc.contributor.author한상원-
dc.contributor.author허지회-
dc.date.accessioned2017-05-04T07:40:10Z-
dc.date.available2017-05-04T07:40:10Z-
dc.date.issued2005-
dc.identifier.issn0891-5849-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/147624-
dc.description.abstractBrain edema is a leading cause of death after stroke. Cytotoxic edema, which is most severe in astrocytes, begins within a few minutes of adenosine triphosphate depletion and reflects the ultimate infarct size. Vasogenic edema is caused by uncontrolled fluid leakage from the blood to the brain parenchyma through a weakened blood–brain barrier (BBB) and contributes to an actual net volume increase of the brain, which often leads to death. Recent research on ischemia-induced injury mechanisms of the microvasculature has led to the disclosure of the mechanisms and cellular pathways leading to BBB breakdown. In addition, the introduction of magnetic resonance imaging to clinical practice has enabled the evaluation of edema severity in stroke patients and differentiation between cytotoxic and vasogenic edema. Free radicals exert their deleterious actions during both cytotoxic and vasogenic edema. They can contribute to BBB disruption directly and can also trigger molecular pathways related to the dysfunction of ion transporters in the cell membrane and those related to increased vascular permeability. The development of effective therapeutic strategies aimed at reducing brain edema based on targeting specific molecular pathways involved may reduce death and disability from stroke.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier Science-
dc.relation.isPartOfFree Radical Biology and Medicine-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHBlood-Brain Barrier/physiopathology-
dc.subject.MESHBrain Edema/diagnosis-
dc.subject.MESHBrain Edema/etiology*-
dc.subject.MESHBrain Edema/therapy-
dc.subject.MESHCerebral Hemorrhage/physiopathology-
dc.subject.MESHEncephalitis/physiopathology-
dc.subject.MESHFibrinolytic Agents/therapeutic use-
dc.subject.MESHFree Radicals/adverse effects*-
dc.subject.MESHHumans-
dc.subject.MESHNeuroprotective Agents/therapeutic use-
dc.subject.MESHStroke/complications*-
dc.subject.MESHTomography Scanners, X-Ray Computed-
dc.titleFree radicals as triggers of brain edema formation after stroke-
dc.typeArticle-
dc.publisher.locationUnited States-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiology (영상의학교실)-
dc.contributor.departmentDept. of Neurology (신경과학교실)-
dc.contributor.departmentDept. of Neurology (신경과학교실)-
dc.contributor.googleauthorJi Hoe Heo-
dc.contributor.googleauthorSang Won Han-
dc.contributor.googleauthorSeung Koo Lee-
dc.identifier.doi10.1016/j.freeradbiomed.2005.03.035-
dc.contributor.localIdA02912-
dc.contributor.localIdA04284-
dc.contributor.localIdA04369-
dc.relation.journalcodeJ00906-
dc.identifier.eissn1873-4596-
dc.identifier.pmid15925278-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0891584905001929-
dc.subject.keywordBrain edema-
dc.subject.keywordFree radicals-
dc.subject.keywordCerebral infarction-
dc.subject.keywordIschemia-
dc.contributor.alternativeNameLee, Seung Koo-
dc.contributor.alternativeNameHan, Sang Won-
dc.contributor.alternativeNameHeo, Ji Hoe-
dc.citation.volume39-
dc.citation.number1-
dc.citation.startPage51-
dc.citation.endPage70-
dc.identifier.bibliographicCitationFree Radical Biology and Medicine, Vol.39(1) : 51-70, 2005-
dc.date.modified2017-05-04-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers

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