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Elastin content of the renal pelvis and ureter determines post-pyeloplasty recovery

Authors
 DONG SUK KIM  ;  J.I. YEUN NOH  ;  HYEON JOO JEONG  ;  MYUNG JOON KIM  ;  HYUNG JIN JEON  ;  SANG WON HAN 
Citation
 JOURNAL OF UROLOGY, Vol.173(3) : 962-966, 2005 
Journal Title
 JOURNAL OF UROLOGY 
ISSN
 0022-5347 
Issue Date
2005
MeSH
Adolescent ; Child ; Child, Preschool ; Elastin/analysis* ; Elastin/metabolism ; Female ; Humans ; Hydronephrosis/metabolism ; Hydronephrosis/surgery* ; Infant ; Infant, Newborn ; Kidney Pelvis/chemistry* ; Kidney Pelvis/surgery* ; Male ; Retrospective Studies ; Ureter/chemistry* ; Urologic Surgical Procedures/rehabilitation
Keywords
15711350
Abstract
PURPOSE: We evaluated the collagen-to-smooth muscle tissue matrix ratio and percentage of elastin in the renal pelvis, ureteropelvic junction (UPJ) and ureter, and compared these findings with the degree of obstruction, patient age and post-pyeloplasty renal recovery. MATERIALS AND METHODS: We analyzed histological sections from 75 patients with UPJ obstruction. Nine patients were excluded owing to bilateral UPJ obstruction and an improper specimen. We divided the specimen obtained from pyeloplasty into 3 parts, namely the renal pelvis above the obstruction, the obstructed UPJ portion and the ureter below the obstruction. To examine the collagen and smooth muscle, sections were stained using Masson's trichrome, and elastic van Giesson stain was used for elastin, smooth muscle and collagen. Collagen, smooth muscle and elastin populations were identified, and the tissue matrix ratio and percentage of elastin were calculated by color image analysis. RESULTS: In patients with lower ratios of collagen-to-smooth muscle in the UPJ proper hydronephrosis was more improved postoperatively (p = 0.049). In patients with a lower percentage of elastin in the renal pelvis, UPJ and ureter hydronephrosis was more improved postoperatively (p <0.0001). CONCLUSIONS: Because the UPJ portion was resected during pyeloplasty, the renal pelvis and the ureter remaining after pyeloplasty are likely to be related to improved hydronephrosis. A higher percentage of elastin in the renal pelvis and ureter contributes to inelasticity and low compliance, and results in a slower recovery from hydronephrosis after pyeloplasty.
Full Text
http://www.sciencedirect.com/science/article/pii/S0022534705604156
DOI
OAK-2005-03147
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dong Seok(김동석)
Kim, Myung Joon(김명준) ORCID logo https://orcid.org/0000-0002-4608-0275
Noh, Ji Yeun(노지연)
Jeon, Hyung Jin(전형진)
Jeong, Hyeon Joo(정현주) ORCID logo https://orcid.org/0000-0002-9695-1227
Han, Sang Won(한상원) ORCID logo https://orcid.org/0000-0003-0941-1300
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/147546
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