0 102

Cited 21 times in

Differential biological responses of green tea polyphenol in normal cells vs. cancer cells

Authors
 Park Han-Ki  ;  Han Dong-Wook  ;  Park Young Hwan  ;  Park Jong-Chul 
Citation
 Current Applied Physics, Vol.5(5) : 449-452, 2005 
Journal Title
 Current Applied Physics 
ISSN
 1567-1739 
Issue Date
2005
Abstract
Green tea has shown remarkable anti-inflammatory and cancer chemopreventive effects in many animal tumor bioassays, cell culture systems and epidemiological studies. Many of these biological effects of green tea are mediated by epigallocatechin 3-gallate, the major polyphenol present therein. In this study, the differential biological responses of green tea polyphenols (GTP) were examined in normal rat osteoblasts (NRO) vs. human osteosarcoma (MG-63 and Saos-2) cells. The GTP treatment with micromolar concentrations (0.1, 1, 10 and 100 μM for 24 h) resulted in dose-dependent inhibitions of cell growth and alkaline phosphatase activity, morphological alterations, G0/G1-phase arrest of the cell cycle and induction of apoptosis in both osteosarcoma cells, but not in the NRO. These results suggest that the GTP treatment may be contributed to the differential regulation of cell cycle in normal cells and cancer cells, which can be exploited to craft strategies for the physiological preservation of cells or tissues by GTP.
Full Text
http://www.sciencedirect.com/science/article/pii/S1567173905000131
DOI
10.1016/j.cap.2005.01.008
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
Yonsei Authors
Park, Young Hwan(박영환)
Park, Jong Chul(박종철) ORCID logo https://orcid.org/0000-0003-0083-5991
Park, Han Ki(박한기) ORCID logo https://orcid.org/0000-0002-7472-7822
Han, Dong Wook(한동욱)
Export
RIS (EndNote)
XLS (Excel)
XML
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/147493
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse