Cited 28 times in
Differential biological responses of green tea polyphenol in normal cells vs. cancer cells
DC Field | Value | Language |
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dc.contributor.author | 박영환 | - |
dc.contributor.author | 박종철 | - |
dc.contributor.author | 박한기 | - |
dc.contributor.author | 한동욱 | - |
dc.date.accessioned | 2017-05-04T07:34:44Z | - |
dc.date.available | 2017-05-04T07:34:44Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 1567-1739 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/147493 | - |
dc.description.abstract | Green tea has shown remarkable anti-inflammatory and cancer chemopreventive effects in many animal tumor bioassays, cell culture systems and epidemiological studies. Many of these biological effects of green tea are mediated by epigallocatechin 3-gallate, the major polyphenol present therein. In this study, the differential biological responses of green tea polyphenols (GTP) were examined in normal rat osteoblasts (NRO) vs. human osteosarcoma (MG-63 and Saos-2) cells. The GTP treatment with micromolar concentrations (0.1, 1, 10 and 100 μM for 24 h) resulted in dose-dependent inhibitions of cell growth and alkaline phosphatase activity, morphological alterations, G0/G1-phase arrest of the cell cycle and induction of apoptosis in both osteosarcoma cells, but not in the NRO. These results suggest that the GTP treatment may be contributed to the differential regulation of cell cycle in normal cells and cancer cells, which can be exploited to craft strategies for the physiological preservation of cells or tissues by GTP. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | CURRENT APPLIED PHYSICS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Green tea polyphenols | - |
dc.subject.MESH | Normal rat osteoblasts | - |
dc.subject.MESH | Human osteosarcoma cells | - |
dc.subject.MESH | Cell cycle arrest | - |
dc.subject.MESH | Physiological preservation | - |
dc.title | Differential biological responses of green tea polyphenol in normal cells vs. cancer cells | - |
dc.type | Article | - |
dc.publisher.location | Netherlands | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) | - |
dc.contributor.department | Dept. of Medical Engineering (의학공학교실) | - |
dc.contributor.department | Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) | - |
dc.contributor.department | Dept. of Medical Engineering (의학공학교실) | - |
dc.contributor.googleauthor | Park Han-Ki | - |
dc.contributor.googleauthor | Han Dong-Wook | - |
dc.contributor.googleauthor | Park Young Hwan | - |
dc.contributor.googleauthor | Park Jong-Chul | - |
dc.identifier.doi | 10.1016/j.cap.2005.01.008 | - |
dc.contributor.localId | A01574 | - |
dc.contributor.localId | A01662 | - |
dc.contributor.localId | A01729 | - |
dc.contributor.localId | A04275 | - |
dc.relation.journalcode | J00659 | - |
dc.identifier.eissn | 1878-1675 | - |
dc.identifier.pmid | 10.1016/j.cap.2005.01.008 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S1567173905000131 | - |
dc.subject.keyword | Green tea polyphenols | - |
dc.subject.keyword | Normal rat osteoblasts | - |
dc.subject.keyword | Human osteosarcoma cells | - |
dc.subject.keyword | Cell cycle arrest | - |
dc.subject.keyword | Physiological preservation | - |
dc.contributor.alternativeName | Park, Young Hwan | - |
dc.contributor.alternativeName | Park, Jong Chul | - |
dc.contributor.alternativeName | Park, Han Ki | - |
dc.contributor.alternativeName | Han, Dong Wook | - |
dc.citation.volume | 5 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 449 | - |
dc.citation.endPage | 452 | - |
dc.identifier.bibliographicCitation | CURRENT APPLIED PHYSICS, Vol.5(5) : 449-452, 2005 | - |
dc.date.modified | 2017-05-04 | - |
dc.identifier.rimsid | 40272 | - |
dc.type.rims | ART | - |
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