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Enhanced neurite outgrowth of rat neural cortical cells on surface-modified films of poly(lactic-co-glycolic acid)

Authors
 Dong-Wook Han  ;  Min Sub Lee  ;  Bong Joo Park  ;  Jeong Koo Kim  ;  Jong-Chul Park 
Citation
 BIOTECHNOLOGY LETTERS, Vol.27(1) : 53-58, 2005 
Journal Title
 BIOTECHNOLOGY LETTERS 
ISSN
 0141-5492 
Issue Date
2005
MeSH
Animals ; Cells, Cultured ; Fluorescent Antibody Technique ; Glycolates/chemistry* ; Immunohistochemistry ; Lactic Acid ; Microscopy, Electron, Scanning ; Neurites* ; Neurons/cytology* ; Neurons/ultrastructure ; Polyglycolic Acid ; Polylactic Acid-Polyglycolic Acid Copolymer ; Rats ; Surface Properties
Keywords
extracellular matrix ; neurite outgrowth ; poly(lactic-co-glycolic acid) ; rat neural cortical cell
Abstract
Neural cortical cells, isolated from prenatal rat cerebra, were grown on surface-modified poly(lactic-co-glycolic acid, 65:35) (PLGA) films coated with poly-D-lysine (PDL) with either laminin (LN), fibronectin (FN) or collagen (CN). Immunocytochemistry showed that the isolated cells were highly immunopositive for both neurofilament and MAP-2 with well-organized neurites and somatodendritic localization. The presence of PDL with LN or FN on the PLGA films was essential for increased neural cell growth. Also, PLGA films coated with either PDL/LN or PDL/FN mixtures had higher neurite outgrowth and regular differentiation.
Full Text
http://link.springer.com/article/10.1007%2Fs10529-004-6585-2
DOI
10.1007/s10529-004-6585-2
Appears in Collections:
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
Yonsei Authors
Park, Bong Joo(박봉주)
Park, Jong Chul(박종철) ORCID logo https://orcid.org/0000-0003-0083-5991
Han, Dong Wook(한동욱)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/147453
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