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Effects of Methylprednisolone on the Neural Conduction of the Motor Evoked Potentials in Spinal Cord Injured Rats

Authors
 Bae Hwan Lee  ;  Kyung Hee Lee  ;  Do Heum Yoon  ;  Un Jeng Kim  ;  Yong Soon Hwang  ;  Sang Keun Park  ;  Joong Uhn Choi  ;  Yong Gou Park 
Citation
 JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.20(1) : 132-138, 2005 
Journal Title
JOURNAL OF KOREAN MEDICAL SCIENCE
ISSN
 1011-8934 
Issue Date
2005
MeSH
Animals ; Disease Models, Animal ; Electrophysiology ; Evoked Potentials, Motor/drug effects* ; Free Radicals ; Glucocorticoids/metabolism ; Male ; Methylprednisolone/pharmacology* ; Neurons/drug effects* ; Oxygen/metabolism ; Rats ; Rats, Sprague-Dawley ; Receptors, Glucocorticoid/metabolism ; Sodium Chloride/pharmacology ; Spinal Cord/pathology ; Spinal Cord Injuries/drug therapy* ; Time Factors
Keywords
Spinal Cord Injuries ; Methylprednisolone ; Behavior ; Evoked Potentials ; Recovery of Function
Abstract
Methylprednisolone (MP), a glucocorticoid steroid, has an anti-inflammatory action and seems to inhibit the formation of oxygen free radicals produced during lipid peroxidation in a spinal cord injury (SCI). However, the effects of MP on the functional recovery after a SCI is controversial. The present study was conducted to determine the effects of MP on the recovery of neural conduction following a SCI. A SCI was produced using the NYU spinal cord impactor. A behavioral test was conducted to measure neurological disorders, and motor evoked potentials (MEPs) were recorded. According to the behavioral test, using BBB locomotor scaling, MP-treated animals showed improved functional recoveries when compared to salinetreated animals. MEP latencies in the MP-treated group were shortened when compared to those in the control group. Peak amplitudes of MEPs were larger in the MP-treated group than those in the control group. The thresholds of MEPs tended to be lower in the MP-treated group than those in the control group. These results suggest that MP may improve functional recovery after a SCI.
Files in This Item:
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DOI
10.3346/jkms.2005.20.1.132
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kim, Un Jeng(김은정) ORCID logo https://orcid.org/0000-0003-0968-0252
Park, Yong Gou(박용구)
Yoon, Do Heum(윤도흠) ORCID logo https://orcid.org/0000-0003-1452-5724
Lee, Bae Hwan(이배환) ORCID logo https://orcid.org/0000-0003-4719-9021
Choi, Joong Uhn(최중언)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/147445
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