Cited 11 times in
Effects of Methylprednisolone on the Neural Conduction of the Motor Evoked Potentials in Spinal Cord Injured Rats
DC Field | Value | Language |
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dc.contributor.author | 김은정 | - |
dc.contributor.author | 박용구 | - |
dc.contributor.author | 윤도흠 | - |
dc.contributor.author | 이배환 | - |
dc.contributor.author | 최중언 | - |
dc.date.accessioned | 2017-05-04T07:33:06Z | - |
dc.date.available | 2017-05-04T07:33:06Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/147445 | - |
dc.description.abstract | Methylprednisolone (MP), a glucocorticoid steroid, has an anti-inflammatory action and seems to inhibit the formation of oxygen free radicals produced during lipid peroxidation in a spinal cord injury (SCI). However, the effects of MP on the functional recovery after a SCI is controversial. The present study was conducted to determine the effects of MP on the recovery of neural conduction following a SCI. A SCI was produced using the NYU spinal cord impactor. A behavioral test was conducted to measure neurological disorders, and motor evoked potentials (MEPs) were recorded. According to the behavioral test, using BBB locomotor scaling, MP-treated animals showed improved functional recoveries when compared to salinetreated animals. MEP latencies in the MP-treated group were shortened when compared to those in the control group. Peak amplitudes of MEPs were larger in the MP-treated group than those in the control group. The thresholds of MEPs tended to be lower in the MP-treated group than those in the control group. These results suggest that MP may improve functional recovery after a SCI. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | 대한의학회(The Korean Academy of Medical Sciences) | - |
dc.relation.isPartOf | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Disease Models, Animal | - |
dc.subject.MESH | Electrophysiology | - |
dc.subject.MESH | Evoked Potentials, Motor/drug effects* | - |
dc.subject.MESH | Free Radicals | - |
dc.subject.MESH | Glucocorticoids/metabolism | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Methylprednisolone/pharmacology* | - |
dc.subject.MESH | Neurons/drug effects* | - |
dc.subject.MESH | Oxygen/metabolism | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Receptors, Glucocorticoid/metabolism | - |
dc.subject.MESH | Sodium Chloride/pharmacology | - |
dc.subject.MESH | Spinal Cord/pathology | - |
dc.subject.MESH | Spinal Cord Injuries/drug therapy* | - |
dc.subject.MESH | Time Factors | - |
dc.title | Effects of Methylprednisolone on the Neural Conduction of the Motor Evoked Potentials in Spinal Cord Injured Rats | - |
dc.type | Article | - |
dc.publisher.location | Korea (South) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Physiology (생리학교실) | - |
dc.contributor.department | Dept. of Neurosurgery (신경외과학교실) | - |
dc.contributor.department | Dept. of Neurosurgery (신경외과학교실) | - |
dc.contributor.department | Dept. of Physiology (생리학교실) | - |
dc.contributor.department | Dept. of Neurosurgery (신경외과학교실) | - |
dc.contributor.googleauthor | Bae Hwan Lee | - |
dc.contributor.googleauthor | Kyung Hee Lee | - |
dc.contributor.googleauthor | Do Heum Yoon | - |
dc.contributor.googleauthor | Un Jeng Kim | - |
dc.contributor.googleauthor | Yong Soon Hwang | - |
dc.contributor.googleauthor | Sang Keun Park | - |
dc.contributor.googleauthor | Joong Uhn Choi | - |
dc.contributor.googleauthor | Yong Gou Park | - |
dc.identifier.doi | 10.3346/jkms.2005.20.1.132 | - |
dc.contributor.localId | A00817 | - |
dc.contributor.localId | A01578 | - |
dc.contributor.localId | A02546 | - |
dc.contributor.localId | A02791 | - |
dc.contributor.localId | A04194 | - |
dc.relation.journalcode | J01517 | - |
dc.identifier.eissn | 1598-6357 | - |
dc.identifier.pmid | 15716618 | - |
dc.subject.keyword | Spinal Cord Injuries | - |
dc.subject.keyword | Methylprednisolone | - |
dc.subject.keyword | Behavior | - |
dc.subject.keyword | Evoked Potentials | - |
dc.subject.keyword | Recovery of Function | - |
dc.contributor.alternativeName | Kim, Un Jeng | - |
dc.contributor.alternativeName | Park, Yong Gou | - |
dc.contributor.alternativeName | Yoon, Do Heum | - |
dc.contributor.alternativeName | Lee, Bae Hwan | - |
dc.contributor.alternativeName | Choi, Joong Uhn | - |
dc.citation.volume | 20 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 132 | - |
dc.citation.endPage | 138 | - |
dc.identifier.bibliographicCitation | JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.20(1) : 132-138, 2005 | - |
dc.date.modified | 2017-05-04 | - |
dc.identifier.rimsid | 40227 | - |
dc.type.rims | ART | - |
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