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Characteristics of Resting-State Functional Connectivity in HIV-Associated Neurocognitive Disorder.

Authors
 Hea Won Ann  ;  Suhnyoung Jun  ;  Na-Young Shin  ;  Sanghoon Han  ;  Jin Young Ahn  ;  Mi Young Ahn  ;  Yong Duk Jeon  ;  In Young Jung  ;  Moo Hyun Kim  ;  Woo Yong Jeong  ;  Nam Su Ku  ;  June Myung Kim  ;  Davey M. Smith  ;  Jun Yong Choi 
Citation
 PLoS One, Vol.11(4) : e0153493, 2016 
Journal Title
 PLoS One 
Issue Date
2016
MeSH
AIDS Dementia Complex/diagnostic imaging ; AIDS Dementia Complex/physiopathology* ; Connectome* ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neuropsychological Tests
Abstract
BACKGROUND: HIV-associated neurocognitive disorder (HAND) can occur in patients without prior AIDS defining illness and can be debilitating. This study aimed to evaluate the difference in the patterns of intrinsic brain activity between patients with or without HAND for deepening our understanding of HAND. METHODS: We evaluated 24 HIV-infected individuals, 12 with previously diagnosed HAND and 12 previously diagnosed without HAND, and 11 seronegative individuals. These individuals then underwent repeat NP testing and a functional brain MRI scan. For functional MRI analysis, seed-based analysis with bilateral precuneus cortex seed was applied. RESULTS: Among the 12 individuals with previously diagnosed HAND, 3 showed improvement of their neurocognitive function and 1 was excluded for worsening liver disease. Among the 12 patients who previously had normal neurocognitive function, 2 showed neurocognitive impairment. Overall, the HAND group, who had impaired cognitive function at the time of MRI scan, showed significant decrease of resting status functional connectivity between bilateral precuneus and prefrontal cortex (PFC) compared with nonHAND group, those who had normal neurocognitive function (Corrected P<0.05). The functional connectivity with the right inferior frontal operculum and right superior frontal gyrus was positively correlated with memory and learning ability. CONCLUSIONS: This cross-sectional study found a significant difference in fMRI patterns between patients with and without HAND. Decreased functional connectivity between precuneus and PFC could be possible functional substrate for cognitive dysfunction in HIV patients, which should be characterized in a longitudinal study.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/147142
Files in This Item:
T201602208.pdf Download
DOI
10.1371/journal.pone.0153493
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실)
Yonsei Authors
구남수(Ku, Nam Su) ORCID logo https://orcid.org/0000-0002-9717-4327
김무현(Kim, Moo Hyun)
김준명(Kim, June Myung)
신나영(Shin, Na Young)
안미영(Ahn, Mi Young)
안진영(Ahn, Jin Young)
전용덕(Jeon, Yong Duk)
정우용(Jeong, Wooyong)
정인영(Jung, In Young)
최준용(Choi, Jun Yong) ORCID logo https://orcid.org/0000-0002-2775-3315
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