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Retinal Nerve Fiber Layer Thickness is Decreased in Patients With Hematologic Malignancy.

 Jinu Han  ;  Ji Hyun Kim  ;  Hanna Yoo  ;  Sueng-Han Han  ;  Samin Hong  ;  Gong Je Seong  ;  Chan Yun Kim 
 JOURNAL OF GLAUCOMA, Vol.25(3) : 175-181, 2016 
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Adult ; Anemia, Iron-Deficiency/blood ; Anemia, Iron-Deficiency/complications* ; Anemia, Iron-Deficiency/diagnosis ; Bone Marrow Transplantation ; Cross-Sectional Studies ; Erythrocyte Count ; Erythrocyte Indices ; Female ; Gonioscopy ; Hemoglobins/metabolism ; Humans ; Intraocular Pressure ; Male ; Middle Aged ; Nerve Fibers/pathology* ; Optic Nerve Diseases/blood ; Optic Nerve Diseases/diagnosis ; Optic Nerve Diseases/etiology* ; Prospective Studies ; Retinal Ganglion Cells/pathology* ; Tomography, Optical Coherence/methods ; Tonometry, Ocular ; Vision Disorders/physiopathology ; Visual Field Tests ; Visual Fields/physiology
retinal nerve fiber layer ; anemia ; nonarteritic ischemic optic neuropathy
PURPOSE: To investigate whether retinal nerve fiber layer (RNFL) thickness is decreased in patients with hematologic malignancy using optical coherence tomography (OCT). PATIENTS AND METHODS: This prospective, observational cross-sectional study included 65 eyes from 34 patients with hematologic malignancy and 72 healthy control eyes. OCT-measured RNFL thickness parameters (average, 4 quadrants, and 12 clock-hour thickness) and RNFL defect in red-free photo were compared between patients with hematologic malignancy and controls. RESULTS: Among average, quadrant, and clock-hour map, the only 11-o'clock RNFL in patients with hematologic malignancy was statistically thinner than in controls (P=0.021). The RNFL defect was detected in 21/65 (32.3%) patients with hematologic malignancy and in 5/72 (6.9%) controls (P<0.001). In patients with hematologic malignancy, the mean RNFL thickness was significantly lower in the severe and moderate anemia groups compared with the mild anemia group (P=0.011). In the generalized estimating equations model, the mean hemoglobin level was associated with RNFL thickness while correcting for inter-eye correlation, age, and refraction error (coefficient=3.685, P=0.006). CONCLUSIONS: The RNFL defect was frequently observed, and the RNFL was thinner in severe anemic patients with hematologic malignancy. These results suggest that chronic anemia may be a factor of RNFL loss.
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1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Ji Hyun(김지현)
Kim, Chan Yun(김찬윤) ORCID logo https://orcid.org/0000-0002-8373-9999
Seong, Gong Je(성공제) ORCID logo https://orcid.org/0000-0002-5456-4296
Han, Seung Han(한승한) ORCID logo https://orcid.org/0000-0001-8972-4790
Han, Jinu(한진우) ORCID logo https://orcid.org/0000-0002-8607-6625
Hong, Sa Min(홍사민)
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