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Cardiopulmonary fitness, adiponectin, chemerin associated fasting insulin level in colorectal cancer patients.

Authors
 Ki-Yong Ahn  ;  Mi Kyung Lee  ;  Dong-Il Kim  ;  Jihye Park  ;  Jihee Min  ;  Hyuk In Yang  ;  Junga Lee  ;  Minsuk Oh  ;  Joongbae An  ;  Ji-Won Lee  ;  Sang Hui Chu  ;  Jeffrey A. Meyerhardt  ;  Nam-Kyu Kim  ;  Justin Y. Jeon 
Citation
 Supportive Care in Cancer, Vol.24(7) : 2927-2935, 2016 
Journal Title
 Supportive Care in Cancer 
ISSN
 0941-4355 
Issue Date
2016
MeSH
Adiponectin/metabolism* ; Chimerin Proteins/metabolism* ; Colorectal Neoplasms ; Exercise/physiology* ; Female ; Humans ; Insulin/metabolism* ; Male ; Middle Aged
Keywords
Adiponectin ; Chemerin ; Colorectal cancer ; Fitness ; Insulin
Abstract
PURPOSE: Since circulating level of insulin is associated with colorectal cancer prognosis, it is important to identify factors contributing to fasting insulin level in colorectal cancer patients. The purpose of the current study is to investigate the association of physical fitness, adiponectin, and chemerin levels with circulating level of insulin in colorectal cancer patients. METHODS: A total of 123 stage II-III colorectal cancer patients who completed standard cancer treatment were recruited. Anthropometric characteristics, fitness measurements, fasting insulin level, homeostasis model assessment of insulin resistance, lipid profiles, and adiponectin and chemerin levels were analyzed. RESULT: Cardiopulmonary fitness level inversely associated with fasting insulin levels (the least fit (1st tertile): 8.11 ± 0.64, moderately fit (2nd tertile): 6.02 ± 0.63, and highly fit (3rd tertile): 5.58 ± 0.66 μU/ml, unfit vs. moderately fit, p < 0.01; unfit vs. highly fit, p < 0.05) after adjustment for gender, age, stage, and BMI. In addition, fasting adiponectin and chemerin levels were associated with fasting insulin levels after adjustment for gender, age, stage, and BMI. In our combined analyses, participants with high adiponectin and low chemerin levels showed significantly lower fasting insulin levels (4.92 ± 0.75 vs. 8.07 ± 0.80 μU/ml, p < 0.01) compared with participants with low adiponectin and high chemerin levels. Multiple linear regression analysis confirmed that cardiopulmonary fitness and adiponectin levels (β = -0.299, p = 0.002; β = -0.201, p = 0.033) were independently associated with fasting insulin level. CONCLUSION: Our results suggest that physical fitness and adiponectin and chemerin levels may contribute to circulating levels of insulin. These results suggest that exercise may influence the prognosis of colorectal cancer patients by influencing physical fitness level, circulating levels of adiponectin and chemerin.
Full Text
http://link.springer.com/article/10.1007/s00520-016-3095-4
DOI
10.1007/s00520-016-3095-4
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
3. College of Nursing (간호대학) > Dept. of Nursing (간호학과) > 1. Journal Papers
Yonsei Authors
김남규(Kim, Nam Kyu) ORCID logo https://orcid.org/0000-0003-0639-5632
안중배(Ahn, Joong Bae) ORCID logo https://orcid.org/0000-0001-6787-1503
이지원(Lee, Ji Won) ORCID logo https://orcid.org/0000-0002-2666-4249
추상희(Chu, Sang Hui) ORCID logo https://orcid.org/0000-0001-6877-5599
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/146903
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