282 202

Cited 8 times in

A single gene of a commensal microbe affects host susceptibility to enteric infection.

 Mi Young Yoon  ;  Kyung Bae Min  ;  Kang-Mu Lee  ;  Yujin Yoon  ;  Yaeseul Kim  ;  Young Taek Oh  ;  Keehoon Lee  ;  Jongsik Chun  ;  Byung-Yong Kim  ;  Seok-Hwan Yoon  ;  Insuk Lee  ;  Chan Yeong Kim  ;  Sang Sun Yoon 
 NATURE COMMUNICATIONS, Vol.7 : 11606, 2016 
Journal Title
Issue Date
Indigenous microbes inside the host intestine maintain a complex self-regulating community. The mechanisms by which gut microbes interact with intestinal pathogens remain largely unknown. Here we identify a commensal Escherichia coli strain whose expansion predisposes mice to infection by Vibrio cholerae, a human pathogen. We refer to this strain as 'atypical' E. coli (atEc) because of its inability to ferment lactose. The atEc strain is resistant to reactive oxygen species (ROS) and proliferates extensively in antibiotic-treated adult mice. V. cholerae infection is more severe in neonatal mice transplanted with atEc compared with those transplanted with a typical E. coli strain. Intestinal ROS levels are decreased in atEc-transplanted mice, favouring proliferation of ROS-sensitive V. cholerae. An atEc mutant defective in ROS degradation fails to facilitate V. cholerae infection when transplanted, suggesting that host infection susceptibility can be regulated by a single gene product of one particular commensal species.
Files in This Item:
T201601472.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Yoon, Sang Sun(윤상선) ORCID logo https://orcid.org/0000-0003-2979-365X
Lee, Kang Mu(이강무) ORCID logo https://orcid.org/0000-0001-7414-5921
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.