Cited 27 times in
A single gene of a commensal microbe affects host susceptibility to enteric infection.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 윤상선 | - |
dc.contributor.author | 이강무 | - |
dc.contributor.author | 윤미영 | - |
dc.date.accessioned | 2017-02-24T11:45:38Z | - |
dc.date.available | 2017-02-24T11:45:38Z | - |
dc.date.issued | 2016 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/146853 | - |
dc.description.abstract | Indigenous microbes inside the host intestine maintain a complex self-regulating community. The mechanisms by which gut microbes interact with intestinal pathogens remain largely unknown. Here we identify a commensal Escherichia coli strain whose expansion predisposes mice to infection by Vibrio cholerae, a human pathogen. We refer to this strain as 'atypical' E. coli (atEc) because of its inability to ferment lactose. The atEc strain is resistant to reactive oxygen species (ROS) and proliferates extensively in antibiotic-treated adult mice. V. cholerae infection is more severe in neonatal mice transplanted with atEc compared with those transplanted with a typical E. coli strain. Intestinal ROS levels are decreased in atEc-transplanted mice, favouring proliferation of ROS-sensitive V. cholerae. An atEc mutant defective in ROS degradation fails to facilitate V. cholerae infection when transplanted, suggesting that host infection susceptibility can be regulated by a single gene product of one particular commensal species. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Nature Pub. Group | - |
dc.relation.isPartOf | NATURE COMMUNICATIONS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | A single gene of a commensal microbe affects host susceptibility to enteric infection. | - |
dc.type | Article | - |
dc.publisher.location | England | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Microbiology | - |
dc.contributor.googleauthor | Mi Young Yoon | - |
dc.contributor.googleauthor | Kyung Bae Min | - |
dc.contributor.googleauthor | Kang-Mu Lee | - |
dc.contributor.googleauthor | Yujin Yoon | - |
dc.contributor.googleauthor | Yaeseul Kim | - |
dc.contributor.googleauthor | Young Taek Oh | - |
dc.contributor.googleauthor | Keehoon Lee | - |
dc.contributor.googleauthor | Jongsik Chun | - |
dc.contributor.googleauthor | Byung-Yong Kim | - |
dc.contributor.googleauthor | Seok-Hwan Yoon | - |
dc.contributor.googleauthor | Insuk Lee | - |
dc.contributor.googleauthor | Chan Yeong Kim | - |
dc.contributor.googleauthor | Sang Sun Yoon | - |
dc.identifier.doi | 10.1038/ncomms11606 | - |
dc.contributor.localId | A02558 | - |
dc.contributor.localId | A02638 | - |
dc.relation.journalcode | J02293 | - |
dc.identifier.eissn | 2041-1723 | - |
dc.identifier.pmid | 27173141 | - |
dc.contributor.alternativeName | Yoon, Sang Sun | - |
dc.contributor.alternativeName | Lee, Kang Mu | - |
dc.contributor.affiliatedAuthor | Yoon, Sang Sun | - |
dc.contributor.affiliatedAuthor | Lee, Kang Mu | - |
dc.citation.volume | 7 | - |
dc.citation.startPage | 11606 | - |
dc.identifier.bibliographicCitation | NATURE COMMUNICATIONS, Vol.7 : 11606, 2016 | - |
dc.date.modified | 2017-02-24 | - |
dc.identifier.rimsid | 47948 | - |
dc.type.rims | ART | - |
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