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A single gene of a commensal microbe affects host susceptibility to enteric infection.

DC FieldValueLanguage
dc.contributor.author윤상선-
dc.contributor.author이강무-
dc.date.accessioned2017-02-24T11:45:38Z-
dc.date.available2017-02-24T11:45:38Z-
dc.date.issued2016-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/146853-
dc.description.abstractIndigenous microbes inside the host intestine maintain a complex self-regulating community. The mechanisms by which gut microbes interact with intestinal pathogens remain largely unknown. Here we identify a commensal Escherichia coli strain whose expansion predisposes mice to infection by Vibrio cholerae, a human pathogen. We refer to this strain as 'atypical' E. coli (atEc) because of its inability to ferment lactose. The atEc strain is resistant to reactive oxygen species (ROS) and proliferates extensively in antibiotic-treated adult mice. V. cholerae infection is more severe in neonatal mice transplanted with atEc compared with those transplanted with a typical E. coli strain. Intestinal ROS levels are decreased in atEc-transplanted mice, favouring proliferation of ROS-sensitive V. cholerae. An atEc mutant defective in ROS degradation fails to facilitate V. cholerae infection when transplanted, suggesting that host infection susceptibility can be regulated by a single gene product of one particular commensal species.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherNature Pub. Group-
dc.relation.isPartOfNATURE COMMUNICATIONS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleA single gene of a commensal microbe affects host susceptibility to enteric infection.-
dc.typeArticle-
dc.publisher.locationEngland-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Microbiology-
dc.contributor.googleauthorMi Young Yoon-
dc.contributor.googleauthorKyung Bae Min-
dc.contributor.googleauthorKang-Mu Lee-
dc.contributor.googleauthorYujin Yoon-
dc.contributor.googleauthorYaeseul Kim-
dc.contributor.googleauthorYoung Taek Oh-
dc.contributor.googleauthorKeehoon Lee-
dc.contributor.googleauthorJongsik Chun-
dc.contributor.googleauthorByung-Yong Kim-
dc.contributor.googleauthorSeok-Hwan Yoon-
dc.contributor.googleauthorInsuk Lee-
dc.contributor.googleauthorChan Yeong Kim-
dc.contributor.googleauthorSang Sun Yoon-
dc.identifier.doi10.1038/ncomms11606-
dc.contributor.localIdA02558-
dc.contributor.localIdA02638-
dc.relation.journalcodeJ02293-
dc.identifier.eissn2041-1723-
dc.identifier.pmid27173141-
dc.contributor.alternativeNameYoon, Sang Sun-
dc.contributor.alternativeNameLee, Kang Mu-
dc.contributor.affiliatedAuthorYoon, Sang Sun-
dc.contributor.affiliatedAuthorLee, Kang Mu-
dc.citation.volume7-
dc.citation.startPage11606-
dc.identifier.bibliographicCitationNATURE COMMUNICATIONS, Vol.7 : 11606, 2016-
dc.date.modified2017-02-24-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers

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