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A Case of ALK-Rearranged Adenocarcinoma with Small Cell Carcinoma-Like Transformation and Resistance to Crizotinib

Authors
 Yoon Jin Cha  ;  Byoung Chul Cho  ;  Hye Ryun Kim  ;  Hye-Jeong Lee  ;  Hyo Sup Shim 
Citation
 Journal of Thoracic Oncology, Vol.11(5) : 55-58, 2016 
Journal Title
 Journal of Thoracic Oncology 
ISSN
 1556-0864 
Issue Date
2016
MeSH
Abdominal Neoplasms/drug therapy ; Abdominal Neoplasms/genetics* ; Abdominal Neoplasms/secondary ; Adenocarcinoma/drug therapy ; Adenocarcinoma/genetics ; Adenocarcinoma/pathology ; Aged ; Cell Transformation, Neoplastic/drug effects ; Cell Transformation, Neoplastic/genetics* ; Cell Transformation, Neoplastic/pathology ; Drug Resistance, Neoplasm/genetics* ; Gene Rearrangement* ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Male ; Protein Kinase Inhibitors/pharmacology ; Pyrazoles/pharmacology* ; Pyridines/pharmacology* ; Receptor Protein-Tyrosine Kinases/genetics* ; Small Cell Lung Carcinoma/drug therapy ; Small Cell Lung Carcinoma/genetics* ; Small Cell Lung Carcinoma/pathology
Keywords
Anaplastic lymphoma kinase ; Crizotinib ; Lung adenocarcinoma ; Resistance ; Small cell lung carcinoma
Abstract
Histologic changes can be involved in resistance to anticancer drugs. Transformation to small cell lung carcinoma (SCLC) following treatment with EGFR tyrosine kinase inhibitors has been reported in patients with EGFR-mutant lung adenocarcinoma. Herein, we report a case of ALK-rearranged lung adenocarcinoma with SCLC-like histology in a metastatic abdominal nodule that was resistant to crizotinib therapy.
Full Text
http://www.sciencedirect.com/science/article/pii/S1556086415002142
DOI
10.1016/j.jtho.2015.12.097
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
김혜련(Kim, Hye Ryun) ORCID logo https://orcid.org/0000-0002-1842-9070
심효섭(Shim, Hyo Sup) ORCID logo https://orcid.org/0000-0002-5718-3624
이혜정(Lee, Hye Jeong) ORCID logo https://orcid.org/0000-0003-4349-9174
조병철(Cho, Byoung Chul) ORCID logo https://orcid.org/0000-0002-5562-270X
차윤진(Cha, Yoon Jin) ORCID logo https://orcid.org/0000-0002-5967-4064
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/146825
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