A Case of ALK-Rearranged Adenocarcinoma with Small Cell Carcinoma-Like Transformation and Resistance to Crizotinib

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Authors: Yoon Jin Cha ; Byoung Chul Cho ; Hye Ryun Kim ; Hye-Jeong Lee ; Hyo Sup Shim

MeSH: Abdominal Neoplasms/drug therapy ; Abdominal Neoplasms/genetics* ; Abdominal Neoplasms/secondary ; Adenocarcinoma/drug therapy ; Adenocarcinoma/genetics ; Adenocarcinoma/pathology ; Aged ; Cell Transformation, Neoplastic/drug effects ; Cell Transformation, Neoplastic/genetics* ; Cell Transformation, Neoplastic/pathology ; Drug Resistance, Neoplasm/genetics* ; Gene Rearrangement* ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Male ; Protein Kinase Inhibitors/pharmacology ; Pyrazoles/pharmacology* ; Pyridines/pharmacology* ; Receptor Protein-Tyrosine Kinases/genetics* ; Small Cell Lung Carcinoma/drug therapy ; Small Cell Lung Carcinoma/genetics* ; Small Cell Lung Carcinoma/pathology

Keywords: Anaplastic lymphoma kinase ; Crizotinib ; Lung adenocarcinoma ; Resistance ; Small cell lung carcinoma

Abstract: Histologic changes can be involved in resistance to anticancer drugs. Transformation to small cell lung carcinoma (SCLC) following treatment with EGFR tyrosine kinase inhibitors has been reported in patients with EGFR-mutant lung adenocarcinoma. Herein, we report a case of ALK-rearranged lung adenocarcinoma with SCLC-like histology in a metastatic abdominal nodule that was resistant to crizotinib therapy.

Full Text: http://www.sciencedirect.com/science/article/pii/S1556086415002142

Appears in Collections:: 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

Yonsei Authors: Kim, Hye Ryun(김혜련) https://orcid.org/0000-0002-1842-9070
Shim, Hyo Sup(심효섭) https://orcid.org/0000-0002-5718-3624
Lee, Hye Jeong(이혜정) https://orcid.org/0000-0003-4349-9174
Cho, Byoung Chul(조병철) https://orcid.org/0000-0002-5562-270X
Cha, Yoon Jin(차윤진) https://orcid.org/0000-0002-5967-4064

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