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Prognostic impact of cytological fluid tumor markers in non-small cell lung cancer.

 Arthur Cho  ;  Jin Hur  ;  Yoo Jin Hong  ;  Hye-Jeong Lee  ;  Young Jin Kim  ;  Sae Rom Hong  ;  Young Joo Suh  ;  Dong Jin Im  ;  Yun Jung Kim  ;  Jae Seok Lee  ;  Hyo Sup Shim  ;  Byoung Wook Choi 
 TUMOR BIOLOGY, Vol.37(3) : 3205-3213, 2016 
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Issue Date
Adult ; Aged ; Aged, 80 and over ; Antigens, Neoplasm/blood ; Antigens, Neoplasm/metabolism ; Biomarkers, Tumor/blood ; Biomarkers, Tumor/metabolism* ; Biopsy, Fine-Needle ; Carcinoembryonic Antigen/blood ; Carcinoembryonic Antigen/metabolism ; Carcinoma, Non-Small-Cell Lung/blood ; Carcinoma, Non-Small-Cell Lung/metabolism* ; Carcinoma, Non-Small-Cell Lung/pathology ; Female ; Follow-Up Studies ; Humans ; Kaplan-Meier Estimate ; Keratin-19/blood ; Keratin-19/metabolism ; Lung/metabolism* ; Lung/pathology ; Lung Neoplasms/blood ; Lung Neoplasms/metabolism* ; Lung Neoplasms/pathology ; Male ; Middle Aged ; Multivariate Analysis ; Prognosis ; Prospective Studies ; Serpins/blood ; Serpins/metabolism
Cytologic SCC Ag ; Cytologic tumor marker ; NSCLC ; Prognosis ; Serum CYFRA 21–1
The serum tumor markers CYFRA 21-1, carcinoembryonic antigen (CEA), and squamous cell carcinoma antigen (SCCA) are useful in diagnosis and prognosis of non-small cell lung cancer (NSCLC). Cytologic tumor markers obtained during needle aspiration biopsies (NAB) of lung lesions are useful for NSCLC diagnosis. This study investigated the incremental prognostic value of cytologic tumor markers compared to serum tumor markers. This prospective study included 253 patients diagnosed with NSCLC by NAB with cytologic tumor marker analysis. Levels of cytologic CYFRA 21-1, CEA, SCCA, and their serum counterparts were followed up for survival analysis. Optimal cutoff values for each tumor marker were obtained for overall survival (OS) and progression-free survival (PFS) analyses. All patients were followed up for a median of 22.8 months. Using cutoff values of 0.44 ng/ml for C-SCCA, 2.0 ng/ml for S-SCCA, and 3.3 ng/ml for S-CYFRA, a multivariate analysis revealed that high S-SCCA (hazard ratio, HR, 1.84) and high C-SCCA (HR, 1.63) were independent predictive factors of OS. The 3-year overall survival rate was 55 vs. 80 % for high and low C-SCCA, respectively. Cytologic tumor marker level detection is easily obtainable and provides prognostic information for NSCLC. Cytologic tumor markers provide comparable prognostic information relative to serum tumor markers, with C-SCCA acting as a strong prognostic factor of overall survival and PFS.
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1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Young Jin(김영진) ORCID logo https://orcid.org/0000-0002-6235-6550
Suh, Young Joo(서영주) ORCID logo https://orcid.org/0000-0002-2078-5832
Shim, Hyo Sup(심효섭) ORCID logo https://orcid.org/0000-0002-5718-3624
Lee, Jae Seok(이재석)
Lee, Hye Jeong(이혜정) ORCID logo https://orcid.org/0000-0003-4349-9174
Im, Dong Jin(임동진) ORCID logo https://orcid.org/0000-0001-8139-5646
Cho, Arthur Eung Hyuck(조응혁) ORCID logo https://orcid.org/0000-0001-8670-2473
Choi, Byoung Wook(최병욱) ORCID logo https://orcid.org/0000-0002-8873-5444
Hur, Jin(허진) ORCID logo https://orcid.org/0000-0002-8651-6571
Hong, Yoo Jin(홍유진) ORCID logo https://orcid.org/0000-0002-7276-0944
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