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Prognostic impact of cytological fluid tumor markers in non-small cell lung cancer.

 Arthur Cho  ;  Jin Hur  ;  Yoo Jin Hong  ;  Hye-Jeong Lee  ;  Young Jin Kim  ;  Sae Rom Hong  ;  Young Joo Suh  ;  Dong Jin Im  ;  Yun Jung Kim  ;  Jae Seok Lee  ;  Hyo Sup Shim  ;  Byoung Wook Choi 
 Tumor Biology, Vol.37(3) : 3205-3213, 2016 
Journal Title
 Tumor Biology 
Issue Date
Adult ; Aged ; Aged, 80 and over ; Antigens, Neoplasm/blood ; Antigens, Neoplasm/metabolism ; Biomarkers, Tumor/blood ; Biomarkers, Tumor/metabolism* ; Biopsy, Fine-Needle ; Carcinoembryonic Antigen/blood ; Carcinoembryonic Antigen/metabolism ; Carcinoma, Non-Small-Cell Lung/blood ; Carcinoma, Non-Small-Cell Lung/metabolism* ; Carcinoma, Non-Small-Cell Lung/pathology ; Female ; Follow-Up Studies ; Humans ; Kaplan-Meier Estimate ; Keratin-19/blood ; Keratin-19/metabolism ; Lung/metabolism* ; Lung/pathology ; Lung Neoplasms/blood ; Lung Neoplasms/metabolism* ; Lung Neoplasms/pathology ; Male ; Middle Aged ; Multivariate Analysis ; Prognosis ; Prospective Studies ; Serpins/blood ; Serpins/metabolism
Cytologic SCC Ag ; Cytologic tumor marker ; NSCLC ; Prognosis ; Serum CYFRA 21–1
The serum tumor markers CYFRA 21-1, carcinoembryonic antigen (CEA), and squamous cell carcinoma antigen (SCCA) are useful in diagnosis and prognosis of non-small cell lung cancer (NSCLC). Cytologic tumor markers obtained during needle aspiration biopsies (NAB) of lung lesions are useful for NSCLC diagnosis. This study investigated the incremental prognostic value of cytologic tumor markers compared to serum tumor markers. This prospective study included 253 patients diagnosed with NSCLC by NAB with cytologic tumor marker analysis. Levels of cytologic CYFRA 21-1, CEA, SCCA, and their serum counterparts were followed up for survival analysis. Optimal cutoff values for each tumor marker were obtained for overall survival (OS) and progression-free survival (PFS) analyses. All patients were followed up for a median of 22.8 months. Using cutoff values of 0.44 ng/ml for C-SCCA, 2.0 ng/ml for S-SCCA, and 3.3 ng/ml for S-CYFRA, a multivariate analysis revealed that high S-SCCA (hazard ratio, HR, 1.84) and high C-SCCA (HR, 1.63) were independent predictive factors of OS. The 3-year overall survival rate was 55 vs. 80 % for high and low C-SCCA, respectively. Cytologic tumor marker level detection is easily obtainable and provides prognostic information for NSCLC. Cytologic tumor markers provide comparable prognostic information relative to serum tumor markers, with C-SCCA acting as a strong prognostic factor of overall survival and PFS.
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1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
김영진(Kim, Young Jin) ORCID logo https://orcid.org/0000-0002-6235-6550
서영주(Suh, Young Joo) ORCID logo https://orcid.org/0000-0002-2078-5832
심효섭(Shim, Hyo Sup) ORCID logo https://orcid.org/0000-0002-5718-3624
이재석(Lee, Jae Seok)
이혜정(Lee, Hye Jeong) ORCID logo https://orcid.org/0000-0003-4349-9174
임동진(Im, Dong Jin) ORCID logo https://orcid.org/0000-0001-8139-5646
조응혁(Cho, Arthur Eung Hyuck) ORCID logo https://orcid.org/0000-0001-8670-2473
최병욱(Choi, Byoung Wook) ORCID logo https://orcid.org/0000-0002-8873-5444
허진(Hur, Jin) ORCID logo https://orcid.org/0000-0002-8651-6571
홍유진(Hong, Yoo Jin) ORCID logo https://orcid.org/0000-0002-7276-0944
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