Cited 4 times in
Prognostic impact of cytological fluid tumor markers in non-small cell lung cancer.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김영진 | - |
dc.contributor.author | 임동진 | - |
dc.contributor.author | 조응혁 | - |
dc.contributor.author | 최병욱 | - |
dc.contributor.author | 허진 | - |
dc.contributor.author | 홍유진 | - |
dc.contributor.author | 서영주 | - |
dc.contributor.author | 심효섭 | - |
dc.contributor.author | 이재석 | - |
dc.contributor.author | 이혜정 | - |
dc.date.accessioned | 2017-02-24T11:39:04Z | - |
dc.date.available | 2017-02-24T11:39:04Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1010-4283 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/146823 | - |
dc.description.abstract | The serum tumor markers CYFRA 21-1, carcinoembryonic antigen (CEA), and squamous cell carcinoma antigen (SCCA) are useful in diagnosis and prognosis of non-small cell lung cancer (NSCLC). Cytologic tumor markers obtained during needle aspiration biopsies (NAB) of lung lesions are useful for NSCLC diagnosis. This study investigated the incremental prognostic value of cytologic tumor markers compared to serum tumor markers. This prospective study included 253 patients diagnosed with NSCLC by NAB with cytologic tumor marker analysis. Levels of cytologic CYFRA 21-1, CEA, SCCA, and their serum counterparts were followed up for survival analysis. Optimal cutoff values for each tumor marker were obtained for overall survival (OS) and progression-free survival (PFS) analyses. All patients were followed up for a median of 22.8 months. Using cutoff values of 0.44 ng/ml for C-SCCA, 2.0 ng/ml for S-SCCA, and 3.3 ng/ml for S-CYFRA, a multivariate analysis revealed that high S-SCCA (hazard ratio, HR, 1.84) and high C-SCCA (HR, 1.63) were independent predictive factors of OS. The 3-year overall survival rate was 55 vs. 80 % for high and low C-SCCA, respectively. Cytologic tumor marker level detection is easily obtainable and provides prognostic information for NSCLC. Cytologic tumor markers provide comparable prognostic information relative to serum tumor markers, with C-SCCA acting as a strong prognostic factor of overall survival and PFS. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.format.extent | 3205~3213 | - |
dc.language | English | - |
dc.publisher | Springer Netherlands | - |
dc.relation.isPartOf | TUMOR BIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Antigens, Neoplasm/blood | - |
dc.subject.MESH | Antigens, Neoplasm/metabolism | - |
dc.subject.MESH | Biomarkers, Tumor/blood | - |
dc.subject.MESH | Biomarkers, Tumor/metabolism* | - |
dc.subject.MESH | Biopsy, Fine-Needle | - |
dc.subject.MESH | Carcinoembryonic Antigen/blood | - |
dc.subject.MESH | Carcinoembryonic Antigen/metabolism | - |
dc.subject.MESH | Carcinoma, Non-Small-Cell Lung/blood | - |
dc.subject.MESH | Carcinoma, Non-Small-Cell Lung/metabolism* | - |
dc.subject.MESH | Carcinoma, Non-Small-Cell Lung/pathology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Kaplan-Meier Estimate | - |
dc.subject.MESH | Keratin-19/blood | - |
dc.subject.MESH | Keratin-19/metabolism | - |
dc.subject.MESH | Lung/metabolism* | - |
dc.subject.MESH | Lung/pathology | - |
dc.subject.MESH | Lung Neoplasms/blood | - |
dc.subject.MESH | Lung Neoplasms/metabolism* | - |
dc.subject.MESH | Lung Neoplasms/pathology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Multivariate Analysis | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Serpins/blood | - |
dc.subject.MESH | Serpins/metabolism | - |
dc.title | Prognostic impact of cytological fluid tumor markers in non-small cell lung cancer. | - |
dc.type | Article | - |
dc.publisher.location | Netherlands | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Radiology | - |
dc.contributor.googleauthor | Arthur Cho | - |
dc.contributor.googleauthor | Jin Hur | - |
dc.contributor.googleauthor | Yoo Jin Hong | - |
dc.contributor.googleauthor | Hye-Jeong Lee | - |
dc.contributor.googleauthor | Young Jin Kim | - |
dc.contributor.googleauthor | Sae Rom Hong | - |
dc.contributor.googleauthor | Young Joo Suh | - |
dc.contributor.googleauthor | Dong Jin Im | - |
dc.contributor.googleauthor | Yun Jung Kim | - |
dc.contributor.googleauthor | Jae Seok Lee | - |
dc.contributor.googleauthor | Hyo Sup Shim | - |
dc.contributor.googleauthor | Byoung Wook Choi | - |
dc.identifier.doi | 10.1007/s13277-015-4034-6 | - |
dc.contributor.localId | A00727 | - |
dc.contributor.localId | A03361 | - |
dc.contributor.localId | A03887 | - |
dc.contributor.localId | A04059 | - |
dc.contributor.localId | A04370 | - |
dc.contributor.localId | A04422 | - |
dc.contributor.localId | A01892 | - |
dc.contributor.localId | A02219 | - |
dc.contributor.localId | A03072 | - |
dc.contributor.localId | A03320 | - |
dc.relation.journalcode | J02763 | - |
dc.identifier.eissn | 1423-0380 | - |
dc.identifier.pmid | 26432331 | - |
dc.identifier.url | http://link.springer.com/article/10.1007/s13277-015-4034-6 | - |
dc.subject.keyword | Cytologic SCC Ag | - |
dc.subject.keyword | Cytologic tumor marker | - |
dc.subject.keyword | NSCLC | - |
dc.subject.keyword | Prognosis | - |
dc.subject.keyword | Serum CYFRA 21–1 | - |
dc.contributor.alternativeName | Kim, Young Jin | - |
dc.contributor.alternativeName | Im, Dong Jin | - |
dc.contributor.alternativeName | Cho, Arthur Eung Hyuck | - |
dc.contributor.alternativeName | Choi, Byoung Wook | - |
dc.contributor.alternativeName | Hur, Jin | - |
dc.contributor.alternativeName | Hong, Yoo Jin | - |
dc.contributor.alternativeName | Suh, Young Joo | - |
dc.contributor.alternativeName | Shim, Hyo Sup | - |
dc.contributor.alternativeName | Lee, Jae Seok | - |
dc.contributor.alternativeName | Lee, Hye Jeong | - |
dc.contributor.affiliatedAuthor | Kim, Young Jin | - |
dc.contributor.affiliatedAuthor | Im, Dong Jin | - |
dc.contributor.affiliatedAuthor | Cho, Arthur Eung Hyuck | - |
dc.contributor.affiliatedAuthor | Choi, Byoung Wook | - |
dc.contributor.affiliatedAuthor | Hur, Jin | - |
dc.contributor.affiliatedAuthor | Hong, Yoo Jin | - |
dc.contributor.affiliatedAuthor | Suh, Young Joo | - |
dc.contributor.affiliatedAuthor | Shim, Hyo Sup | - |
dc.contributor.affiliatedAuthor | Lee, Jae Seok | - |
dc.contributor.affiliatedAuthor | Lee, Hye Jeong | - |
dc.citation.volume | 37 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 3205 | - |
dc.citation.endPage | 3213 | - |
dc.identifier.bibliographicCitation | TUMOR BIOLOGY, Vol.37(3) : 3205-3213, 2016 | - |
dc.date.modified | 2017-02-24 | - |
dc.identifier.rimsid | 47565 | - |
dc.type.rims | ART | - |
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