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Value of additional von Kossa staining in thyroid nodules with echogenic spots on ultrasound.

Authors
 In Hye Chae  ;  Hyeong Ju Kwon  ;  Eun-Kyung Kim  ;  Hee Jung Moon  ;  Jung Hyun Yoon  ;  Hye Sun Lee  ;  Jin Young Kwak 
Citation
 Pathology Research and Practice, Vol.212(5) : 415-420, 2016 
Journal Title
 Pathology Research and Practice 
ISSN
 0344-0338 
Issue Date
2016
MeSH
Adult ; Aged ; Aged, 80 and over ; Carcinoma, Papillary/diagnostic imaging ; Carcinoma, Papillary/pathology* ; Cytodiagnosis ; Female ; Humans ; Male ; Middle Aged ; Sensitivity and Specificity ; Staining and Labeling ; Thyroid Gland/diagnostic imaging ; Thyroid Gland/pathology* ; Thyroid Neoplasms/diagnostic imaging ; Thyroid Neoplasms/pathology* ; Thyroid Nodule/diagnostic imaging ; Thyroid Nodule/pathology* ; Ultrasonography* ; Young Adult
Keywords
Psammoma body ; Thyroid neoplasms ; Ultrasound fine-needle aspiration biopsy ; von Kossa stain
Abstract
PURPOSE: To evaluate the clinical value of additional von Kossa staining on cytology in thyroid nodules with echogenic spots on ultrasound (US). MATERIALS AND METHODS: 342 thyroid nodules were analyzed for cytology and von Kossa staining was performed to detect microcalcifications. We compared diagnostic performances and accuracies of FNA and FNA with von Kossa staining to detect malignancy. We evaluated associations of aggressive pathologic features and von Kossa positivity in the surgically confirmed papillary thyroid carcinoma (PTC) group. RESULTS: Two hundred and thirty two (67.8%) nodules were malignant and 110 (32.2%) were benign on cytopathology. Compared to cytology alone, additional von Kossa staining slightly improved sensitivity from 89.7% to 90.9% (P=0.081). In 207 cases of surgically confirmed PTC, von Kossa positivity was an independent predictor of central lymph node metastasis in PTCs by multivariate analysis (odds ratio, 2.218; P=0.021). CONCLUSIONS: Adding von Kossa staining to cytology improved the sensitivity of thyroid nodules with echogenic spots on US. Positive von Kossa stains in PTCs may also be useful in predicting central lymph node metastasis.
Full Text
http://www.sciencedirect.com/science/article/pii/S0344033816300243
DOI
10.1016/j.prp.2016.02.014
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
곽진영(Kwak, Jin Young) ORCID logo https://orcid.org/0000-0002-6212-1495
김은경(Kim, Eun-Kyung) ORCID logo https://orcid.org/0000-0002-3368-5013
문희정(Moon, Hee Jung) ORCID logo https://orcid.org/0000-0002-5643-5885
윤정현(Yoon, Jung Hyun) ORCID logo https://orcid.org/0000-0002-2100-3513
채인혜(Chae, In Hye)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/146808
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