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Lymphangiogenesis in Breast Cancer Correlates with Matrix Stiffness on Shear-Wave Elastography

Authors
 Yoon Jin Cha  ;  Ji Hyun Youk  ;  Baek Gil Kim  ;  Woo Hee Jung  ;  Nam Hoon Cho 
Citation
 YONSEI MEDICAL JOURNAL, Vol.57(3) : 599-605, 2016 
Journal Title
YONSEI MEDICAL JOURNAL
ISSN
 0513-5796 
Issue Date
2016
MeSH
Adult ; Aged ; Aged, 80 and over ; Breast/pathology ; Breast Neoplasms/diagnostic imaging* ; Breast Neoplasms/pathology* ; Elasticity Imaging Techniques/methods* ; Female ; Humans ; Lymph Nodes/pathology ; Lymphangiogenesis/physiology* ; Lymphatic Metastasis/pathology* ; Middle Aged ; Multivariate Analysis ; Neoplasm Invasiveness ; Neoplasm Staging ; Regression Analysis
Keywords
Breast neoplasms ; elasticity imaging techniques ; fibrosis ; lymphangiogenesis
Abstract
PURPOSE: To correlate tumor stiffness and lymphangiogenesis in breast cancer and to find its clinical implications.
MATERIALS AND METHODS: A total of 140 breast cancer patients were evaluated. Tumor stiffness was quantitatively measured by shear-wave elastography in preoperative ultrasound examination, calculated as mean elasticity value (kPa). Slides of resected breast cancer specimens were reviewed for most fibrotic area associated with tumor. D2-40 immunohistochemical staining was applied for fibrotic areas to detect the lymphatic spaces. Microlymphatic density, tumor stiffness, and clinicopathologic data were analyzed.
RESULTS: Higher elasticity value was associated with invasive size of tumor, microlymphatic density, histologic grade 3, absence of extensive intraductal component, presence of axillary lymph node metastasis, and Ki-67 labeling index (LI) in univariate regression analysis, and associated with Ki-67 LI and axillary lymph node metastasis in multivariate regression analysis. Microlymphatic density was associated histologic grade 3, mean elasticity value, and Ki-67 LI in univariate regression analysis. In multivariate regression analysis, microlymphatic density was correlated with mean elasticity value.
CONCLUSION: In breast cancer, tumor stiffness correlates with lymphangiogenesis and poor prognostic factors.
Files in This Item:
T201601278.pdf Download
DOI
10.3349/ymj.2016.57.3.599
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Baek Gil(김백길) ORCID logo https://orcid.org/0000-0001-6270-1433
Youk, Ji Hyun(육지현) ORCID logo https://orcid.org/0000-0002-7787-780X
Jung, Woo Hee(정우희)
Cho, Nam Hoon(조남훈) ORCID logo https://orcid.org/0000-0002-0045-6441
Cha, Yoon Jin(차윤진) ORCID logo https://orcid.org/0000-0002-5967-4064
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/146774
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