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Lymphangiogenesis in Breast Cancer Correlates with Matrix Stiffness on Shear-Wave Elastography

 Yoon Jin Cha  ;  Ji Hyun Youk  ;  Baek Gil Kim  ;  Woo Hee Jung  ;  Nam Hoon Cho 
 Yonsei Medical Journal, Vol.57(3) : 599-605, 2016 
Journal Title
 Yonsei Medical Journal 
Issue Date
Adult ; Aged ; Aged, 80 and over ; Breast/pathology ; Breast Neoplasms/diagnostic imaging* ; Breast Neoplasms/pathology* ; Elasticity Imaging Techniques/methods* ; Female ; Humans ; Lymph Nodes/pathology ; Lymphangiogenesis/physiology* ; Lymphatic Metastasis/pathology* ; Middle Aged ; Multivariate Analysis ; Neoplasm Invasiveness ; Neoplasm Staging ; Regression Analysis
Breast neoplasms ; elasticity imaging techniques ; fibrosis ; lymphangiogenesis
PURPOSE: To correlate tumor stiffness and lymphangiogenesis in breast cancer and to find its clinical implications. MATERIALS AND METHODS: A total of 140 breast cancer patients were evaluated. Tumor stiffness was quantitatively measured by shear-wave elastography in preoperative ultrasound examination, calculated as mean elasticity value (kPa). Slides of resected breast cancer specimens were reviewed for most fibrotic area associated with tumor. D2-40 immunohistochemical staining was applied for fibrotic areas to detect the lymphatic spaces. Microlymphatic density, tumor stiffness, and clinicopathologic data were analyzed. RESULTS: Higher elasticity value was associated with invasive size of tumor, microlymphatic density, histologic grade 3, absence of extensive intraductal component, presence of axillary lymph node metastasis, and Ki-67 labeling index (LI) in univariate regression analysis, and associated with Ki-67 LI and axillary lymph node metastasis in multivariate regression analysis. Microlymphatic density was associated histologic grade 3, mean elasticity value, and Ki-67 LI in univariate regression analysis. In multivariate regression analysis, microlymphatic density was correlated with mean elasticity value. CONCLUSION: In breast cancer, tumor stiffness correlates with lymphangiogenesis and poor prognostic factors.
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1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
김백길(Kim, Baek Gil) ORCID logo https://orcid.org/0000-0001-6270-1433
육지현(Youk, Ji Hyun) ORCID logo https://orcid.org/0000-0002-7787-780X
정우희(Jung, Woo Hee)
조남훈(Cho, Nam Hoon) ORCID logo https://orcid.org/0000-0002-0045-6441
차윤진(Cha, Yoon Jin) ORCID logo https://orcid.org/0000-0002-5967-4064
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