Cited 16 times in
Lymphangiogenesis in Breast Cancer Correlates with Matrix Stiffness on Shear-Wave Elastography
DC Field | Value | Language |
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dc.contributor.author | 김백길 | - |
dc.contributor.author | 육지현 | - |
dc.contributor.author | 정우희 | - |
dc.contributor.author | 조남훈 | - |
dc.contributor.author | 차윤진 | - |
dc.date.accessioned | 2017-02-24T11:27:44Z | - |
dc.date.available | 2017-02-24T11:27:44Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/146774 | - |
dc.description.abstract | PURPOSE: To correlate tumor stiffness and lymphangiogenesis in breast cancer and to find its clinical implications. MATERIALS AND METHODS: A total of 140 breast cancer patients were evaluated. Tumor stiffness was quantitatively measured by shear-wave elastography in preoperative ultrasound examination, calculated as mean elasticity value (kPa). Slides of resected breast cancer specimens were reviewed for most fibrotic area associated with tumor. D2-40 immunohistochemical staining was applied for fibrotic areas to detect the lymphatic spaces. Microlymphatic density, tumor stiffness, and clinicopathologic data were analyzed. RESULTS: Higher elasticity value was associated with invasive size of tumor, microlymphatic density, histologic grade 3, absence of extensive intraductal component, presence of axillary lymph node metastasis, and Ki-67 labeling index (LI) in univariate regression analysis, and associated with Ki-67 LI and axillary lymph node metastasis in multivariate regression analysis. Microlymphatic density was associated histologic grade 3, mean elasticity value, and Ki-67 LI in univariate regression analysis. In multivariate regression analysis, microlymphatic density was correlated with mean elasticity value. CONCLUSION: In breast cancer, tumor stiffness correlates with lymphangiogenesis and poor prognostic factors. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 599~605 | - |
dc.language | English | - |
dc.publisher | Yonsei University | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Breast/pathology | - |
dc.subject.MESH | Breast Neoplasms/diagnostic imaging* | - |
dc.subject.MESH | Breast Neoplasms/pathology* | - |
dc.subject.MESH | Elasticity Imaging Techniques/methods* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lymph Nodes/pathology | - |
dc.subject.MESH | Lymphangiogenesis/physiology* | - |
dc.subject.MESH | Lymphatic Metastasis/pathology* | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Multivariate Analysis | - |
dc.subject.MESH | Neoplasm Invasiveness | - |
dc.subject.MESH | Neoplasm Staging | - |
dc.subject.MESH | Regression Analysis | - |
dc.title | Lymphangiogenesis in Breast Cancer Correlates with Matrix Stiffness on Shear-Wave Elastography | - |
dc.type | Article | - |
dc.publisher.location | Korea (South) | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Pathology | - |
dc.contributor.googleauthor | Yoon Jin Cha | - |
dc.contributor.googleauthor | Ji Hyun Youk | - |
dc.contributor.googleauthor | Baek Gil Kim | - |
dc.contributor.googleauthor | Woo Hee Jung | - |
dc.contributor.googleauthor | Nam Hoon Cho | - |
dc.identifier.doi | 10.3349/ymj.2016.57.3.599 | - |
dc.contributor.localId | A00484 | - |
dc.contributor.localId | A02537 | - |
dc.contributor.localId | A03671 | - |
dc.contributor.localId | A03812 | - |
dc.contributor.localId | A04001 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 26996557 | - |
dc.subject.keyword | Breast neoplasms | - |
dc.subject.keyword | elasticity imaging techniques | - |
dc.subject.keyword | fibrosis | - |
dc.subject.keyword | lymphangiogenesis | - |
dc.contributor.alternativeName | Kim, Baek Gil | - |
dc.contributor.alternativeName | Youk, Ji Hyun | - |
dc.contributor.alternativeName | Jung, Woo Hee | - |
dc.contributor.alternativeName | Cho, Nam Hoon | - |
dc.contributor.alternativeName | Cha, Yoon Jin | - |
dc.contributor.affiliatedAuthor | Kim, Baek Gil | - |
dc.contributor.affiliatedAuthor | Youk, Ji Hyun | - |
dc.contributor.affiliatedAuthor | Jung, Woo Hee | - |
dc.contributor.affiliatedAuthor | Cho, Nam Hoon | - |
dc.contributor.affiliatedAuthor | Cha, Yoon Jin | - |
dc.citation.volume | 57 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 599 | - |
dc.citation.endPage | 605 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.57(3) : 599-605, 2016 | - |
dc.date.modified | 2017-02-24 | - |
dc.identifier.rimsid | 47517 | - |
dc.type.rims | ART | - |
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