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Left Atrial Volume as a Predictor of Left Ventricular Functional Recovery in Patients With Dilated Cardiomyopathy and Absence of Delayed Enhancement in Cardiac Magnetic Resonance

Authors
 JEONGGEUN MOON  ;  CHI YOUNG SHIM  ;  YOUNG-JIN KIM  ;  SUNGHA PARK  ;  SEOK-MIN KANG  ;  NAMSIK CHUNG  ;  JONG-WON HA 
Citation
 JOURNAL OF CARDIAC FAILURE, Vol.22(4) : 265-271, 2016 
Journal Title
JOURNAL OF CARDIAC FAILURE
ISSN
 1071-9164 
Issue Date
2016
MeSH
Adult ; Aged ; Cardiomyopathy, Dilated/diagnostic imaging* ; Cardiomyopathy, Dilated/physiopathology ; Female ; Follow-Up Studies ; Heart Atria/diagnostic imaging* ; Heart Atria/physiopathology ; Humans ; Magnetic Resonance Imaging, Cine* ; Male ; Middle Aged ; Predictive Value of Tests ; Recovery of Function*/physiology ; Retrospective Studies ; Ventricular Dysfunction, Left/diagnostic imaging* ; Ventricular Dysfunction, Left/physiopathology ; Ventricular Function, Left*/physiology
Keywords
Dilated cardiomyopathy ; left atrium ; magnetic resonance imaging ; prognosis
Abstract
BACKGROUND: Improvement of left ventricular (LV) systolic dysfunction can occur in patients with dilated cardiomyopathy (DCM), and it is more frequently observed if patients have no delayed enhancement (DE) in cardiac magnetic resonance imaging (CMR). However, even in the absence of DE, not all patients have functional recovery. We retrospectively investigated the predictors of LV functional recovery in patients with DCM who had no DE in CMR.
METHODS: A total of 136 patients with DCM underwent CMR. Among them, 44 (29 male, age 55 ± 14 years) showed no DE and these patients composed the study population. The study patients were divided into 2 groups according to the occurrence of functional recovery defined as an increase in LV ejection fraction to a level of ≥50% and net increase in ejection fraction of 20% or more: group 1 (n = 14) with functional recovery and group 2 (n = 30) without functional recovery.
RESULTS: In patients who showed functional recovery, left atrial volume index (LAVI [26 ± 8 mL/m(2) vs 45 ± 18 mL/m(2)]) and LV end-diastolic dimension (62 ± 6 mm vs 67 ± 7 mm) were significantly smaller when compared with those without functional recovery (P <.05 for all). In Cox multiple regression analysis, LAVI was the only significant parameter associated with LV functional recovery (hazard ratio 0.932, 95% confidence interval 0.877-0.991, P = .024). LAVI < 38 mL/m(2) had 100% specificity in predicting the improvement of LV systolic dysfunction.
CONCLUSION: In DCM patients who had no DE in CMR, LAVI predicts LV functional recovery with high specificity.
Full Text
http://www.sciencedirect.com/science/article/pii/S1071916415012208
DOI
10.1016/j.cardfail.2015.12.011
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kang, Seok Min(강석민) ORCID logo https://orcid.org/0000-0001-9856-9227
Kim, Young Jin(김영진) ORCID logo https://orcid.org/0000-0002-6235-6550
Park, Sung Ha(박성하) ORCID logo https://orcid.org/0000-0001-5362-478X
Shim, Chi Young(심지영) ORCID logo https://orcid.org/0000-0002-6136-0136
Chung, Nam Sik(정남식)
Ha, Jong Won(하종원) ORCID logo https://orcid.org/0000-0002-8260-2958
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/146629
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