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Can galectin-3 be a useful marker for conventional papillary thyroid microcarcinoma?

 Hye Mi Gweon  ;  Jeong-Ah Kim  ;  Ji Hyun Youk  ;  Soon Won Hong  ;  Beom Jin Lim  ;  Sun Och Yoon  ;  Young Mi Park  ;  Eun Ju Son 
 DIAGNOSTIC CYTOPATHOLOGY, Vol.44(2) : 103-107, 2016 
Journal Title
Issue Date
Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism* ; Biopsy, Fine-Needle ; Carcinoma, Papillary/diagnosis* ; Female ; Galectin 3/genetics ; Galectin 3/metabolism* ; Humans ; Image-Guided Biopsy ; Male ; Middle Aged ; Thyroid Neoplasms/diagnosis*
fine-needle aspiration ; galectin-3 ; papillary thyroid microcarcinoma
BACKGROUND: Galectin-3 staining of fine-needle aspiration (FNA) samples is very useful for diagnosis of thyroid malignancy. As reported in several studies, galectin-3 is associated with prognostic factor in papillary thyroid carcinoma, but its expression and prognostic role has not been evaluated in papillary microcarcinoma (PTMC). This study was performed to investigate the prevalence of galectin-3 in preoperative ultrasonography (US)-guided FNA cytology and to evaluate the association between galectin-3 expression and prognostic factors of PTMC. METHODS: Between January 2011 and December 2012, 440 conventional PTMCs which had undergone US-guided FNA with galectin-3 analysis and underwent subsequent surgery were enrolled. Preoperative US features and clinicopathologic results including extrathyroidal extension and lymph node metastasis were compared between galectin-3 positive and galectin-3 negative PTMC. RESULTS: Of the 440 PTMCs, 201 (45.7%) PTMCs had galectin-3 positivity in preoperative FNA samples. There was no significant difference in US features between galectin-3 positive and negative PTMC. Galectin-3 expression had no significant association with prognostic factors such as extrathyroidal extension (44.8% vs. 44.8%, P = 0.999) and lymph node metastasis (25.9% vs. 26.8%, P = 0.914) in conventional PTMC. CONCLUSION: Preoperative galectin-3 analysis using FNA cytology may be not advisable in patients with conventional PTMC.
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1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Gweon, Hye Mi(권혜미) ORCID logo https://orcid.org/0000-0002-3054-1532
Kim, Jeong Ah(김정아) ORCID logo https://orcid.org/0000-0003-4949-4913
Son, Eun Ju(손은주) ORCID logo https://orcid.org/0000-0002-7895-0335
Youk, Ji Hyun(육지현) ORCID logo https://orcid.org/0000-0002-7787-780X
Yoon, Sun Och(윤선옥) ORCID logo https://orcid.org/0000-0002-5115-1402
Lim, Beom Jin(임범진) ORCID logo https://orcid.org/0000-0003-2856-0133
Hong, Soon Won(홍순원) ORCID logo https://orcid.org/0000-0002-0324-2414
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