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Can galectin-3 be a useful marker for conventional papillary thyroid microcarcinoma?

 Hye Mi Gweon  ;  Jeong-Ah Kim  ;  Ji Hyun Youk  ;  Soon Won Hong  ;  Beom Jin Lim  ;  Sun Och Yoon  ;  Young Mi Park  ;  Eun Ju Son 
 Diagnostic Cytopathology, Vol.44(2) : 103-107, 2016 
Journal Title
 Diagnostic Cytopathology 
Issue Date
Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism* ; Biopsy, Fine-Needle ; Carcinoma, Papillary/diagnosis* ; Female ; Galectin 3/genetics ; Galectin 3/metabolism* ; Humans ; Image-Guided Biopsy ; Male ; Middle Aged ; Thyroid Neoplasms/diagnosis*
fine-needle aspiration ; galectin-3 ; papillary thyroid microcarcinoma
BACKGROUND: Galectin-3 staining of fine-needle aspiration (FNA) samples is very useful for diagnosis of thyroid malignancy. As reported in several studies, galectin-3 is associated with prognostic factor in papillary thyroid carcinoma, but its expression and prognostic role has not been evaluated in papillary microcarcinoma (PTMC). This study was performed to investigate the prevalence of galectin-3 in preoperative ultrasonography (US)-guided FNA cytology and to evaluate the association between galectin-3 expression and prognostic factors of PTMC. METHODS: Between January 2011 and December 2012, 440 conventional PTMCs which had undergone US-guided FNA with galectin-3 analysis and underwent subsequent surgery were enrolled. Preoperative US features and clinicopathologic results including extrathyroidal extension and lymph node metastasis were compared between galectin-3 positive and galectin-3 negative PTMC. RESULTS: Of the 440 PTMCs, 201 (45.7%) PTMCs had galectin-3 positivity in preoperative FNA samples. There was no significant difference in US features between galectin-3 positive and negative PTMC. Galectin-3 expression had no significant association with prognostic factors such as extrathyroidal extension (44.8% vs. 44.8%, P = 0.999) and lymph node metastasis (25.9% vs. 26.8%, P = 0.914) in conventional PTMC. CONCLUSION: Preoperative galectin-3 analysis using FNA cytology may be not advisable in patients with conventional PTMC.
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1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
권혜미(Gweon, Hye Mi) ORCID logo https://orcid.org/0000-0002-3054-1532
김정아(Kim, Jeong Ah) ORCID logo https://orcid.org/0000-0003-4949-4913
손은주(Son, Eun Ju) ORCID logo https://orcid.org/0000-0002-7895-0335
육지현(Youk, Ji Hyun) ORCID logo https://orcid.org/0000-0002-7787-780X
윤선옥(Yoon, Sun Och) ORCID logo https://orcid.org/0000-0002-5115-1402
임범진(Lim, Beom Jin) ORCID logo https://orcid.org/0000-0003-2856-0133
홍순원(Hong, Soon Won) ORCID logo https://orcid.org/0000-0002-0324-2414
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