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간문맥 혈전이 동반된 진행성 간세포암에서의 동시 항암 화학-방사선요법

Other Titles
 Concurrent Chemo - Radiation Therapy for Advanced Hepatocellular Carcinoma with Portal Vein Thrombosis 
Authors
 김진석  ;  한광협  ;  이도연  ;  성진실  ;  윤영훈  ;  정재연  ;  안상훈  ;  전재윤  ;  문영명 
Citation
 Korean Journal of Hepatology (대한간학회지), Vol.8(1) : 71-79, 2002 
Journal Title
Korean Journal of Hepatology(대한간학회지)
ISSN
 1226-0479 
Issue Date
2002
MeSH
Antineoplastic Agents/administration & dosage* ; Carcinoma, Hepatocellular/complications ; Carcinoma, Hepatocellular/radiotherapy ; Carcinoma, Hepatocellular/therapy* ; Cisplatin/administration & dosage ; Combined Modality Therapy ; Female ; Fluorouracil/administration & dosage ; Humans ; Infusions, Intra-Arterial ; Liver Neoplasms/complications ; Liver Neoplasms/radiotherapy ; Liver Neoplasms/therapy* ; Male ; Middle Aged ; Portal Vein* ; Prognosis ; Venous Thrombosis/complications*
Keywords
Neoplasm/Liver/ Hepatocellular carcinoma ; Portal vein thrombosis ; Chemo-radiation therapy ; Cisplatin
Abstract
Background/Aims: Advanced hepatocellular carcinoma with portal vein thrombosis has a poor prognosis. This study was undertaken to evaluate the therapeutic effects of concurrent chemo-radiation therapy in advanced hepatocellular carcinoma with portal vein thrombosis. Methods: A total of 54 patients with advanced hepatocellular carcinoma (TNM stage IVa) were enrolled. Nineteen patients were treated with external beam radiotherapy (4,500 cGy/ 5 weeks) and intrahepatic arterial 5-FU infusion (500 mg on 1-5 day and 30-35 day, respectively) via implanted chemoport. The others were treated with intrahepatic arterial cisplatin infusion (80 mg/m2). Results: In patients treated with concurrent chemo-radiation therapy, response rates at 2nd and 6th months were 42.1% and 26.3%, respectively. In patients treated with intrahepatic arterial cisplatin therapy, response rates at 2nd and 6th months were 2.9% and 0%, respectively. The median survival time was 11.6 months in concurrent chemo-radiation therapy and 4.8 months in intrahepatic arterial cisplatin infusion therapy. Concurrent chemo-radiation therapy produced better response rates and longer survival time than those of intrahepatic arterial cisplatin infusion therapy (p<0.05). Conclusions: Concurrent chemo-radiation therapy achieved favorable results in advanced hepatocellular carcinoma with portal vein thrombosis and can be considered as a treatment option for the management of advanced hepatocellular carcinoma
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
Yonsei Authors
Seong, Jin Sil(성진실) ORCID logo https://orcid.org/0000-0003-1794-5951
Ahn, Sang Hoon(안상훈) ORCID logo https://orcid.org/0000-0002-3629-4624
Lee, Do Yun(이도연)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/144252
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