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Low dose and slow titration of topiramate as adjunctive therapy in refractory partial epilepsies: a multicentre open clinical trial

Authors
 KOREAN TOPIRAMATE STUDY GROUP 
Citation
 SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, Vol.11(4) : 255-260, 2002 
Journal Title
 SEIZURE-EUROPEAN JOURNAL OF EPILEPSY 
ISSN
 1059-1311 
Issue Date
2002
MeSH
Adolescent ; Adult ; Aged ; Anticonvulsants/administration & dosage ; Anticonvulsants/therapeutic use* ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Drug Therapy, Combination ; Epilepsy, Partial, Motor/drug therapy* ; Female ; Fructose/administration & dosage ; Fructose/analogs & derivatives ; Fructose/therapeutic use* ; Humans ; Male ; Middle Aged ; Topiramate
Keywords
topiramate ; slow titration ; efficacy ; safety
Abstract
Purpose: A multicentre open clinical trial was conducted to evaluate the clinical usefulness of a slower titration of topiramate (TPM) to 300 mg /day as adjunctive therapy for medically intractable partial epilepsies. Methods: Ninteen centres participated in the trial. Study patients had to have had two or more seizures per 4 weeks whilst taking maximum tolerated doses of one but not more than two anti-epileptic drugs. The starting dose of TPM was 25 mg /day and the dose was increased weekly by 25 mg /day until 100 mg /day was reached. Thereafter TPM was increased by 50 mg /day weekly up to the target dose of 300 mg /day, which was followed by an 8 week maintence phase. Seizure outcomes were measured by intention-to-treat analysis (ITTA) Results: Two hundred and thirteen patients entered the study. Median seizure frequency reduction rate was 44.8%, responder rate was 47.6%, and seizure free rate was 9.0%. These results were comparable to that of TPM 600 mg /day in our previous controlled trial. In subgroup analysis, seizure free rate was higher in those patients with a lower baseline seizure frequency rate. Seventeen patients (8.0%) were prematurely withdrawn from the study due to adverse events (AE) or lack of effect. One or more AEs were reported in 22% of patients, with dizziness being the most frequent AE. Other AEs occurred in less than 5% of patients. Conclusion: TPM 300 mg /day was effective and in conjunction with a slower dose-titration, markedly reduced the incidence of AEs, compared with previous study.
Files in This Item:
T200208241.pdf Download
DOI
10.1053/seiz.2001.0605
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
Yonsei Authors
Kim, Won Joo(김원주) ORCID logo https://orcid.org/0000-0002-5850-010X
Roh, Jae Kyung(노재경)
Suh, Chang Ok(서창옥)
Lee, Byung In(이병인)
Lee, Yong Chan(이용찬) ORCID logo https://orcid.org/0000-0001-8800-6906
Heo, Kyoung(허경)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/144236
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