Cited 21 times in
Low dose and slow titration of topiramate as adjunctive therapy in refractory partial epilepsies: a multicentre open clinical trial
DC Field | Value | Language |
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dc.contributor.author | 김원주 | - |
dc.contributor.author | 노재경 | - |
dc.contributor.author | 서창옥 | - |
dc.contributor.author | 이병인 | - |
dc.contributor.author | 이용찬 | - |
dc.contributor.author | 허경 | - |
dc.date.accessioned | 2016-05-16T11:17:52Z | - |
dc.date.available | 2016-05-16T11:17:52Z | - |
dc.date.issued | 2002 | - |
dc.identifier.issn | 1059-1311 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/144236 | - |
dc.description.abstract | Purpose: A multicentre open clinical trial was conducted to evaluate the clinical usefulness of a slower titration of topiramate (TPM) to 300 mg /day as adjunctive therapy for medically intractable partial epilepsies. Methods: Ninteen centres participated in the trial. Study patients had to have had two or more seizures per 4 weeks whilst taking maximum tolerated doses of one but not more than two anti-epileptic drugs. The starting dose of TPM was 25 mg /day and the dose was increased weekly by 25 mg /day until 100 mg /day was reached. Thereafter TPM was increased by 50 mg /day weekly up to the target dose of 300 mg /day, which was followed by an 8 week maintence phase. Seizure outcomes were measured by intention-to-treat analysis (ITTA) Results: Two hundred and thirteen patients entered the study. Median seizure frequency reduction rate was 44.8%, responder rate was 47.6%, and seizure free rate was 9.0%. These results were comparable to that of TPM 600 mg /day in our previous controlled trial. In subgroup analysis, seizure free rate was higher in those patients with a lower baseline seizure frequency rate. Seventeen patients (8.0%) were prematurely withdrawn from the study due to adverse events (AE) or lack of effect. One or more AEs were reported in 22% of patients, with dizziness being the most frequent AE. Other AEs occurred in less than 5% of patients. Conclusion: TPM 300 mg /day was effective and in conjunction with a slower dose-titration, markedly reduced the incidence of AEs, compared with previous study. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 255~260 | - |
dc.relation.isPartOf | SEIZURE-EUROPEAN JOURNAL OF EPILEPSY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Anticonvulsants/administration & dosage | - |
dc.subject.MESH | Anticonvulsants/therapeutic use* | - |
dc.subject.MESH | Dose-Response Relationship, Drug | - |
dc.subject.MESH | Drug Administration Schedule | - |
dc.subject.MESH | DrugTherapy, Combination | - |
dc.subject.MESH | Epilepsy,Partial, Motor/drugtherapy* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Fructose/administration & dosage | - |
dc.subject.MESH | Fructose/analogs & derivatives | - |
dc.subject.MESH | Fructose/therapeutic use* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Topiramate | - |
dc.title | Low dose and slow titration of topiramate as adjunctive therapy in refractory partial epilepsies: a multicentre open clinical trial | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | KOREAN TOPIRAMATE STUDY GROUP | - |
dc.identifier.doi | 10.1053/seiz.2001.0605 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00771 | - |
dc.contributor.localId | A01290 | - |
dc.contributor.localId | A01919 | - |
dc.contributor.localId | A02797 | - |
dc.contributor.localId | A02988 | - |
dc.contributor.localId | A04341 | - |
dc.relation.journalcode | J02648 | - |
dc.identifier.eissn | 1532-2688 | - |
dc.identifier.pmid | 12027573 | - |
dc.subject.keyword | topiramate | - |
dc.subject.keyword | slow titration | - |
dc.subject.keyword | efficacy | - |
dc.subject.keyword | safety | - |
dc.contributor.alternativeName | Kim, Won Joo | - |
dc.contributor.alternativeName | Roh, Jae Kyung | - |
dc.contributor.alternativeName | Suh, Chang Ok | - |
dc.contributor.alternativeName | Lee, Byung In | - |
dc.contributor.alternativeName | Lee, Yong Chan | - |
dc.contributor.alternativeName | Heo, Kyoung | - |
dc.contributor.affiliatedAuthor | Kim, Won Joo | - |
dc.contributor.affiliatedAuthor | Roh, Jae Kyung | - |
dc.contributor.affiliatedAuthor | Suh, Chang Ok | - |
dc.contributor.affiliatedAuthor | Lee, Byung In | - |
dc.contributor.affiliatedAuthor | Lee, Yong Chan | - |
dc.contributor.affiliatedAuthor | Heo, Kyoung | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 11 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 255 | - |
dc.citation.endPage | 260 | - |
dc.identifier.bibliographicCitation | SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, Vol.11(4) : 255-260, 2002 | - |
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