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Low dose and slow titration of topiramate as adjunctive therapy in refractory partial epilepsies: a multicentre open clinical trial

DC Field Value Language
dc.contributor.author김원주-
dc.contributor.author노재경-
dc.contributor.author서창옥-
dc.contributor.author이병인-
dc.contributor.author이용찬-
dc.contributor.author허경-
dc.date.accessioned2016-05-16T11:17:52Z-
dc.date.available2016-05-16T11:17:52Z-
dc.date.issued2002-
dc.identifier.issn1059-1311-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/144236-
dc.description.abstractPurpose: A multicentre open clinical trial was conducted to evaluate the clinical usefulness of a slower titration of topiramate (TPM) to 300 mg /day as adjunctive therapy for medically intractable partial epilepsies. Methods: Ninteen centres participated in the trial. Study patients had to have had two or more seizures per 4 weeks whilst taking maximum tolerated doses of one but not more than two anti-epileptic drugs. The starting dose of TPM was 25 mg /day and the dose was increased weekly by 25 mg /day until 100 mg /day was reached. Thereafter TPM was increased by 50 mg /day weekly up to the target dose of 300 mg /day, which was followed by an 8 week maintence phase. Seizure outcomes were measured by intention-to-treat analysis (ITTA) Results: Two hundred and thirteen patients entered the study. Median seizure frequency reduction rate was 44.8%, responder rate was 47.6%, and seizure free rate was 9.0%. These results were comparable to that of TPM 600 mg /day in our previous controlled trial. In subgroup analysis, seizure free rate was higher in those patients with a lower baseline seizure frequency rate. Seventeen patients (8.0%) were prematurely withdrawn from the study due to adverse events (AE) or lack of effect. One or more AEs were reported in 22% of patients, with dizziness being the most frequent AE. Other AEs occurred in less than 5% of patients. Conclusion: TPM 300 mg /day was effective and in conjunction with a slower dose-titration, markedly reduced the incidence of AEs, compared with previous study.-
dc.description.statementOfResponsibilityopen-
dc.format.extent255~260-
dc.relation.isPartOfSEIZURE-EUROPEAN JOURNAL OF EPILEPSY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAnticonvulsants/administration & dosage-
dc.subject.MESHAnticonvulsants/therapeutic use*-
dc.subject.MESHDose-Response Relationship, Drug-
dc.subject.MESHDrug Administration Schedule-
dc.subject.MESHDrugTherapy, Combination-
dc.subject.MESHEpilepsy,Partial, Motor/drugtherapy*-
dc.subject.MESHFemale-
dc.subject.MESHFructose/administration & dosage-
dc.subject.MESHFructose/analogs & derivatives-
dc.subject.MESHFructose/therapeutic use*-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHTopiramate-
dc.titleLow dose and slow titration of topiramate as adjunctive therapy in refractory partial epilepsies: a multicentre open clinical trial-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorKOREAN TOPIRAMATE STUDY GROUP-
dc.identifier.doi10.1053/seiz.2001.0605-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00771-
dc.contributor.localIdA01290-
dc.contributor.localIdA01919-
dc.contributor.localIdA02797-
dc.contributor.localIdA02988-
dc.contributor.localIdA04341-
dc.relation.journalcodeJ02648-
dc.identifier.eissn1532-2688-
dc.identifier.pmid12027573-
dc.subject.keywordtopiramate-
dc.subject.keywordslow titration-
dc.subject.keywordefficacy-
dc.subject.keywordsafety-
dc.contributor.alternativeNameKim, Won Joo-
dc.contributor.alternativeNameRoh, Jae Kyung-
dc.contributor.alternativeNameSuh, Chang Ok-
dc.contributor.alternativeNameLee, Byung In-
dc.contributor.alternativeNameLee, Yong Chan-
dc.contributor.alternativeNameHeo, Kyoung-
dc.contributor.affiliatedAuthorKim, Won Joo-
dc.contributor.affiliatedAuthorRoh, Jae Kyung-
dc.contributor.affiliatedAuthorSuh, Chang Ok-
dc.contributor.affiliatedAuthorLee, Byung In-
dc.contributor.affiliatedAuthorLee, Yong Chan-
dc.contributor.affiliatedAuthorHeo, Kyoung-
dc.rights.accessRightsfree-
dc.citation.volume11-
dc.citation.number4-
dc.citation.startPage255-
dc.citation.endPage260-
dc.identifier.bibliographicCitationSEIZURE-EUROPEAN JOURNAL OF EPILEPSY, Vol.11(4) : 255-260, 2002-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers

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