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Hydrogen peroxide triggers the expression of Fas/FasL in astrocytoma cell lines and augments apoptosis

Authors
 Daeho Kwon  ;  Chulhee Choi  ;  Jeonggi Lee  ;  Kyung-Ok Kim  ;  Joo-Deuk Kim  ;  Se-Jong Kim  ;  In-Hong Choi 
Citation
 JOURNAL OF NEUROIMMUNOLOGY, Vol.113(1) : 1-9, 2001 
Journal Title
 JOURNAL OF NEUROIMMUNOLOGY 
ISSN
 0165-5728 
Issue Date
2001
MeSH
Apoptosis/drug effects* ; Apoptosis/immunology ; Astrocytoma* ; Fas Ligand Protein ; Gene Expression/drug effects ; Gene Expression/immunology ; Hydrogen Peroxide/pharmacology* ; Membrane Glycoproteins/genetics* ; Oxidants/pharmacology* ; Oxidative Stress/drug effects ; Oxidative Stress/physiology ; Tumor Cells, Cultured/cytology ; Tumor Cells, Cultured/drug effects ; Tumor Cells, Cultured/physiology ; fas Receptor/genetics*
Keywords
Astrocytoma cell lines ; H2O2 ; Fas ; FasL ; Apoptosis
Abstract
Fas expression increases in perinecrotic areas of glioblastoma. In this study the up-regulation of Fas/FasL by oxidative stress was shown. H(2)O(2) exposure increased Fas expression in two astrocytoma cell lines and cells became sensitive to agonistic anti-Fas antibody. FasL was up-regulated in astrocytoma cells. Apoptosis of Molt-4 cells was augmented by astrocytoma cells pretreated with H(2)O(2). Our findings suggest up-regulation of Fas in astrocytoma cells may lead them to be sensitive to apoptosis when cells are in oxidative stress. Whereas, the up-regulation of FasL may render astrocytoma cells cytotoxic to neighboring brain tissues and infiltrating immune cells.
Full Text
http://www.sciencedirect.com/science/article/pii/S0165572800003210
DOI
10.1016/S0165-5728(00)00321-0
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Se Jong(김세종)
Choi, In Hong(최인홍) ORCID logo https://orcid.org/0000-0001-9851-0137
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/142674
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