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Hydrogen peroxide triggers the expression of Fas/FasL in astrocytoma cell lines and augments apoptosis

Authors
 Daeho Kwon ; Chulhee Choi ; In-Hong Choi ; Se-Jong Kim ; Joo-Deuk Kim ; Kyung-Ok Kim ; Jeonggi Lee 
Citation
 Journal of Neuroimmunology, Vol.113(1) : 1~9, 2001 
Journal Title
 Journal of Neuroimmunology 
ISSN
 0165-5728 
Issue Date
2001
Abstract
Fas expression increases in perinecrotic areas of glioblastoma. In this study the up-regulation of Fas/FasL by oxidative stress was shown. H(2)O(2) exposure increased Fas expression in two astrocytoma cell lines and cells became sensitive to agonistic anti-Fas antibody. FasL was up-regulated in astrocytoma cells. Apoptosis of Molt-4 cells was augmented by astrocytoma cells pretreated with H(2)O(2). Our findings suggest up-regulation of Fas in astrocytoma cells may lead them to be sensitive to apoptosis when cells are in oxidative stress. Whereas, the up-regulation of FasL may render astrocytoma cells cytotoxic to neighboring brain tissues and infiltrating immune cells.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/142674
DOI
10.1016/S0165-5728(00)00321-0
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Microbiology
Yonsei Authors
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Link
 http://www.sciencedirect.com/science/article/pii/S0165572800003210
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