Cited 36 times in
Hydrogen peroxide triggers the expression of Fas/FasL in astrocytoma cell lines and augments apoptosis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김세종 | - |
dc.contributor.author | 최인홍 | - |
dc.date.accessioned | 2016-02-19T11:13:33Z | - |
dc.date.available | 2016-02-19T11:13:33Z | - |
dc.date.issued | 2001 | - |
dc.identifier.issn | 0165-5728 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/142674 | - |
dc.description.abstract | Fas expression increases in perinecrotic areas of glioblastoma. In this study the up-regulation of Fas/FasL by oxidative stress was shown. H(2)O(2) exposure increased Fas expression in two astrocytoma cell lines and cells became sensitive to agonistic anti-Fas antibody. FasL was up-regulated in astrocytoma cells. Apoptosis of Molt-4 cells was augmented by astrocytoma cells pretreated with H(2)O(2). Our findings suggest up-regulation of Fas in astrocytoma cells may lead them to be sensitive to apoptosis when cells are in oxidative stress. Whereas, the up-regulation of FasL may render astrocytoma cells cytotoxic to neighboring brain tissues and infiltrating immune cells. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1~9 | - |
dc.relation.isPartOf | JOURNAL OF NEUROIMMUNOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Apoptosis/drug effects* | - |
dc.subject.MESH | Apoptosis/immunology | - |
dc.subject.MESH | Astrocytoma* | - |
dc.subject.MESH | Fas Ligand Protein | - |
dc.subject.MESH | Gene Expression/drug effects | - |
dc.subject.MESH | Gene Expression/immunology | - |
dc.subject.MESH | Hydrogen Peroxide/pharmacology* | - |
dc.subject.MESH | Membrane Glycoproteins/genetics* | - |
dc.subject.MESH | Oxidants/pharmacology* | - |
dc.subject.MESH | Oxidative Stress/drug effects | - |
dc.subject.MESH | Oxidative Stress/physiology | - |
dc.subject.MESH | Tumor Cells, Cultured/cytology | - |
dc.subject.MESH | Tumor Cells, Cultured/drug effects | - |
dc.subject.MESH | Tumor Cells, Cultured/physiology | - |
dc.subject.MESH | fas Receptor/genetics* | - |
dc.title | Hydrogen peroxide triggers the expression of Fas/FasL in astrocytoma cell lines and augments apoptosis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Microbiology (미생물학) | - |
dc.contributor.googleauthor | Daeho Kwon | - |
dc.contributor.googleauthor | Chulhee Choi | - |
dc.contributor.googleauthor | Jeonggi Lee | - |
dc.contributor.googleauthor | Kyung-Ok Kim | - |
dc.contributor.googleauthor | Joo-Deuk Kim | - |
dc.contributor.googleauthor | Se-Jong Kim | - |
dc.contributor.googleauthor | In-Hong Choi | - |
dc.identifier.doi | 10.1016/S0165-5728(00)00321-0 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00603 | - |
dc.contributor.localId | A04167 | - |
dc.relation.journalcode | J01625 | - |
dc.identifier.eissn | 1872-8421 | - |
dc.identifier.pmid | 11137571 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0165572800003210 | - |
dc.subject.keyword | Astrocytoma cell lines | - |
dc.subject.keyword | H2O2 | - |
dc.subject.keyword | Fas | - |
dc.subject.keyword | FasL | - |
dc.subject.keyword | Apoptosis | - |
dc.contributor.alternativeName | Kim, Se Jong | - |
dc.contributor.alternativeName | Choi, In Hong | - |
dc.contributor.affiliatedAuthor | Kim, Se Jong | - |
dc.contributor.affiliatedAuthor | Choi, In Hong | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 113 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 9 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NEUROIMMUNOLOGY, Vol.113(1) : 1-9, 2001 | - |
dc.identifier.rimsid | 29759 | - |
dc.type.rims | ART | - |
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