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Monthly 5-days 5-fluorouracil and low-dose leucovorin for adjuvant chemotherapy in colon cancer

 Joong B Ahn  ;  Kwang Y Shim  ;  Hei C Jeung  ;  Sun Y Rha  ;  Nae C Yoo  ;  Nam K Kim  ;  Jae K Roh  ;  Jin S Min  ;  Byung S Kim  ;  Hyun C Chung 
 CANCER LETTERS, Vol.167(2) : 215-224, 2001 
Journal Title
Issue Date
Adult ; Aged ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/adverse effects ; Antineoplastic Agents/therapeutic use* ; Chemotherapy, Adjuvant ; Colonic Neoplasms/drug therapy* ; Colonic Neoplasms/mortality ; Drug Administration Schedule ; Female ; Fluorouracil/administration & dosage ; Fluorouracil/adverse effects ; Fluorouracil/therapeutic use* ; Humans ; Leucovorin/administration & dosage ; Leucovorin/adverse effects ; Leucovorin/therapeutic use* ; Male ; Middle Aged ; Recurrence ; Survival Analysis
5-Fluorouracil ; Total dose ; Adjuvant chemotherapy ; Colon cancer
We investigated the dose-related effect of the 5-fluorouracil (5-FU)/leucovorin regimen on survival in 139 colon cancer patients with Dukes’ B2 and C2 stage disease. Chemotherapy consisted of 400 mg/m2 of 5-FU and 20 mg/m2 of leucovorin injected daily for 5 days in every 4 weeks for a maximum of 12 cycles. The total dose of 5-FU administered per body surface area had a significant effect on the 5-year disease-free survival and 5-year overall survival in stage B2 and C2 colon cancer patients (P=0.0018, P=0.0011). Analysis with reference to the median DSDI demonstrated that there was a significant difference in 5-year survival in Dukes’ C2 (P=0.0016), but survival was not affected by the dose intensity. Multivariate analysis demonstrated that only the total dose of 5-FU administered per surface area affected the 5-year disease-free survival and 5-year overall survival (P=0.0016, P=0.0007, respectively). It can be concluded that the total dose of 5-FU administered is important in planned dosage schedule of adjuvant chemotherapy in colon cancer.
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5. Research Institutes (연구소) > Cancer Metastasis Research Center (암전이연구센터) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Roh, Jae Kyung(노재경)
Rha, Sun Young(라선영) ORCID logo https://orcid.org/0000-0002-2512-4531
Ahn, Joong Bae(안중배) ORCID logo https://orcid.org/0000-0001-6787-1503
Chung, Hyun Cheol(정현철) ORCID logo https://orcid.org/0000-0002-0920-9471
Jeung, Hei Cheul(정희철) ORCID logo https://orcid.org/0000-0003-0952-3679
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