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Monthly 5-days 5-fluorouracil and low-dose leucovorin for adjuvant chemotherapy in colon cancer

Authors
 Joong B Ahn ; Kwang Y Shim ; Hyun C Chung ; Byung S Kim ; Jin S Min ; Jae K Roh ; Nam K Kim ; Nae C Yoo ; Sun Y Rha ; Hei C Jeung 
Citation
 Cancer Letters, Vol.167(2) : 215~224, 2001 
Journal Title
 Cancer Letters 
ISSN
 0304-3835 
Issue Date
2001
Abstract
We investigated the dose-related effect of the 5-fluorouracil (5-FU)/leucovorin regimen on survival in 139 colon cancer patients with Dukes’ B2 and C2 stage disease. Chemotherapy consisted of 400 mg/m2 of 5-FU and 20 mg/m2 of leucovorin injected daily for 5 days in every 4 weeks for a maximum of 12 cycles. The total dose of 5-FU administered per body surface area had a significant effect on the 5-year disease-free survival and 5-year overall survival in stage B2 and C2 colon cancer patients (P=0.0018, P=0.0011). Analysis with reference to the median DSDI demonstrated that there was a significant difference in 5-year survival in Dukes’ C2 (P=0.0016), but survival was not affected by the dose intensity. Multivariate analysis demonstrated that only the total dose of 5-FU administered per surface area affected the 5-year disease-free survival and 5-year overall survival (P=0.0016, P=0.0007, respectively). It can be concluded that the total dose of 5-FU administered is important in planned dosage schedule of adjuvant chemotherapy in colon cancer.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/142439
DOI
10.1016/S0304-3835(01)00485-2
Appears in Collections:
1. 연구논문 > 5. Research Institutes > Cancer Metastasis Research Center
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
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Link
 http://www.sciencedirect.com/science/article/pii/S0304383501004852
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