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Monthly 5-days 5-fluorouracil and low-dose leucovorin for adjuvant chemotherapy in colon cancer

Authors
 Joong B Ahn  ;  Kwang Y Shim  ;  Hei C Jeung  ;  Sun Y Rha  ;  Nae C Yoo  ;  Nam K Kim  ;  Jae K Roh  ;  Jin S Min  ;  Byung S Kim  ;  Hyun C Chung 
Citation
 Cancer Letters, Vol.167(2) : 215-224, 2001 
Journal Title
 Cancer Letters 
ISSN
 0304-3835 
Issue Date
2001
Abstract
We investigated the dose-related effect of the 5-fluorouracil (5-FU)/leucovorin regimen on survival in 139 colon cancer patients with Dukes’ B2 and C2 stage disease. Chemotherapy consisted of 400 mg/m2 of 5-FU and 20 mg/m2 of leucovorin injected daily for 5 days in every 4 weeks for a maximum of 12 cycles. The total dose of 5-FU administered per body surface area had a significant effect on the 5-year disease-free survival and 5-year overall survival in stage B2 and C2 colon cancer patients (P=0.0018, P=0.0011). Analysis with reference to the median DSDI demonstrated that there was a significant difference in 5-year survival in Dukes’ C2 (P=0.0016), but survival was not affected by the dose intensity. Multivariate analysis demonstrated that only the total dose of 5-FU administered per surface area affected the 5-year disease-free survival and 5-year overall survival (P=0.0016, P=0.0007, respectively). It can be concluded that the total dose of 5-FU administered is important in planned dosage schedule of adjuvant chemotherapy in colon cancer.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/142439
DOI
10.1016/S0304-3835(01)00485-2
Appears in Collections:
1. Journal Papers (연구논문) > 5. Research Institutes (연구소) > Cancer Metastasis Research Center (암전이연구센터)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
노재경(Roh, Jae Kyung) ; 라선영(Rha, Sun Young) ; 안중배(Ahn, Joong Bae) ; 정현철(Chung, Hyun Cheol) ; 정희철(Jeung, Hei Cheul)
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Full Text
http://www.sciencedirect.com/science/article/pii/S0304383501004852
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