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Monthly 5-days 5-fluorouracil and low-dose leucovorin for adjuvant chemotherapy in colon cancer

DC FieldValueLanguage
dc.contributor.author노재경-
dc.contributor.author라선영-
dc.contributor.author안중배-
dc.contributor.author정현철-
dc.contributor.author정희철-
dc.date.accessioned2016-02-19T11:07:10Z-
dc.date.available2016-02-19T11:07:10Z-
dc.date.issued2001-
dc.identifier.issn0304-3835-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/142439-
dc.description.abstractWe investigated the dose-related effect of the 5-fluorouracil (5-FU)/leucovorin regimen on survival in 139 colon cancer patients with Dukes’ B2 and C2 stage disease. Chemotherapy consisted of 400 mg/m2 of 5-FU and 20 mg/m2 of leucovorin injected daily for 5 days in every 4 weeks for a maximum of 12 cycles. The total dose of 5-FU administered per body surface area had a significant effect on the 5-year disease-free survival and 5-year overall survival in stage B2 and C2 colon cancer patients (P=0.0018, P=0.0011). Analysis with reference to the median DSDI demonstrated that there was a significant difference in 5-year survival in Dukes’ C2 (P=0.0016), but survival was not affected by the dose intensity. Multivariate analysis demonstrated that only the total dose of 5-FU administered per surface area affected the 5-year disease-free survival and 5-year overall survival (P=0.0016, P=0.0007, respectively). It can be concluded that the total dose of 5-FU administered is important in planned dosage schedule of adjuvant chemotherapy in colon cancer.-
dc.description.statementOfResponsibilityopen-
dc.format.extent215~224-
dc.relation.isPartOfCancer Letters-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAntineoplastic Agents/administration & dosage-
dc.subject.MESHAntineoplastic Agents/adverse effects-
dc.subject.MESHAntineoplastic Agents/therapeutic use*-
dc.subject.MESHChemotherapy, Adjuvant-
dc.subject.MESHColonic Neoplasms/drug therapy*-
dc.subject.MESHColonic Neoplasms/mortality-
dc.subject.MESHDrug Administration Schedule-
dc.subject.MESHFemale-
dc.subject.MESHFluorouracil/administration & dosage-
dc.subject.MESHFluorouracil/adverse effects-
dc.subject.MESHFluorouracil/therapeutic use*-
dc.subject.MESHHumans-
dc.subject.MESHLeucovorin/administration & dosage-
dc.subject.MESHLeucovorin/adverse effects-
dc.subject.MESHLeucovorin/therapeutic use*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHRecurrence-
dc.subject.MESHSurvival Analysis-
dc.titleMonthly 5-days 5-fluorouracil and low-dose leucovorin for adjuvant chemotherapy in colon cancer-
dc.typeArticle-
dc.contributor.collegeResearcher Institutes (부설 연구소)-
dc.contributor.departmentCancer Metastasis Research Center (암전이연구센터)-
dc.contributor.googleauthorJoong B Ahn-
dc.contributor.googleauthorKwang Y Shim-
dc.contributor.googleauthorHei C Jeung-
dc.contributor.googleauthorSun Y Rha-
dc.contributor.googleauthorNae C Yoo-
dc.contributor.googleauthorNam K Kim-
dc.contributor.googleauthorJae K Roh-
dc.contributor.googleauthorJin S Min-
dc.contributor.googleauthorByung S Kim-
dc.contributor.googleauthorHyun C Chung-
dc.identifier.doi10.1016/S0304-3835(01)00485-2-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01290-
dc.contributor.localIdA02262-
dc.contributor.localIdA03773-
dc.contributor.localIdA01316-
dc.contributor.localIdA03794-
dc.relation.journalcodeJ00448-
dc.identifier.pmid11369143-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0304383501004852-
dc.subject.keyword5-Fluorouracil-
dc.subject.keywordTotal dose-
dc.subject.keywordAdjuvant chemotherapy-
dc.subject.keywordColon cancer-
dc.contributor.alternativeNameRoh, Jae Kyung-
dc.contributor.alternativeNameRha, Sun Young-
dc.contributor.alternativeNameAhn, Joong Bae-
dc.contributor.alternativeNameChung, Hyun Cheol-
dc.contributor.alternativeNameJeung, Hei Cheul-
dc.contributor.affiliatedAuthorRoh, Jae Kyung-
dc.contributor.affiliatedAuthorAhn, Joong Bae-
dc.contributor.affiliatedAuthorChung, Hyun Cheol-
dc.contributor.affiliatedAuthorRha, Sun Young-
dc.contributor.affiliatedAuthorJeung, Hei Cheul-
dc.rights.accessRightsnot free-
dc.citation.volume167-
dc.citation.number2-
dc.citation.startPage215-
dc.citation.endPage224-
dc.identifier.bibliographicCitationCancer Letters, Vol.167(2) : 215-224, 2001-
Appears in Collections:
5. Research Institutes (연구소) > Cancer Metastasis Research Center (암전이연구센터) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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