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Efficacy of Pre - and Postoperative Chemotherapy in Patients with Osteosarcoma of the Extremities

Authors
 Joo Hyuk Sohn  ;  Sun Young Rha  ;  Hei Cheul Jeung  ;  Hyun Joon Shin  ;  Young Suck Goo  ;  Hyun Cheol Chung  ;  Woo Ick Yang  ;  Soo Bong Hahn  ;  Kyu Ho Shin  ;  Jin Sik Min  ;  Byung Soo Kim  ;  Jae Kyung Roh  ;  Woo Ick Jang 
Citation
 Cancer Research and Treatment, Vol.33(6) : 520-526, 2001 
Journal Title
 Cancer Research and Treatment 
ISSN
 0496-6872 
Issue Date
2001
Keywords
Metastasectomy ; Neoadjuvant chemotherapy ; Osteosarcoma ; Recurrence
Abstract
PURPOSE: We evaluated the treatment efficacy including survival and recurrence, and factors associated with recurrence in osteosarcoma patients treated with preoperative chemotherapy, surgery, and adjuvant chemotherapy.0aMATERIALS AND METHODS: Forty nine patients with osteosarcoma were treated with preoperative chemotherapy with intra-arterial cisplatin and adriamycin infusion for 3 cycles, followed by surgery. According to the pathologic response, if tumor was necrotized more than 90%, the same adjuvant chemotherapy was reintroduced for 3 cycles, and if the response was not enough, then the salvage regimen was introduced. Plain chest film and chest CT scan were taken monthly and every 3 months, respectively. When tumor recurred, the metastasectomy was performed whenever possible. 0aRESULTS: Forty three patients were evaluable with amedian follow up of 53 months. Five-year disease-free and overallsurvival rate was 47.0% and 66.9%, respectively. The recurrence was observed in 22 patients (51.2%) with median time of 12.5 months. Baseline alkaline phosphatase (ALP) was the only significant factor for recurrence (pomths vs 5~12 months).0aCONCLUSION: These results indicates that pre- and postoperative chemotherapy with intra-arterial cisplatin and adriamycin infusion showed comparable treatment efficacy and acceptable toxicities.
Files in This Item:
T200101932.pdf Download
DOI
10.4143/crt.2001.33.6.520
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Cancer Metastasis Research Center (암전이연구센터) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Goo, Young Suck(구영석)
Roh, Jae Kyung(노재경)
Rha, Sun Young(라선영) ORCID logo https://orcid.org/0000-0002-2512-4531
Min, Jin Sik(민진식)
Sohn, Joo Hyuk(손주혁) ORCID logo https://orcid.org/0000-0002-2303-2764
Shin, Kyoo Ho(신규호)
Shin, Hyun Joon(신현준)
Yang, Woo Ick(양우익) ORCID logo https://orcid.org/0000-0002-6084-5019
Chung, Hyun Cheol(정현철) ORCID logo https://orcid.org/0000-0002-0920-9471
Jeung, Hei Cheul(정희철) ORCID logo https://orcid.org/0000-0003-0952-3679
Hahn, Soo Bong(한수봉)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/142278
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