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Efficacy of Pre - and Postoperative Chemotherapy in Patients with Osteosarcoma of the Extremities

Authors
 Joo Hyuk Sohn ; Sun Young Rha ; Woo Ick Jang ; Jae Kyung Roh ; Byung Soo Kim ; Jin Sik Min ; Kyu Ho Shin ; Soo Bong Hahn ; Woo Ick Yang ; Hyun Cheol Chung ; Young Suck Goo ; Hyun Joon Shin ; Hei Cheul Jeung 
Citation
 Cancer Research and Treatment, Vol.33(6) : 520~526, 2001 
Journal Title
 Cancer Research and Treatment 
ISSN
 0496-6872 
Issue Date
2001
Abstract
PURPOSE: We evaluated the treatment efficacy including survival and recurrence, and factors associated with recurrence in osteosarcoma patients treated with preoperative chemotherapy, surgery, and adjuvant chemotherapy.0aMATERIALS AND METHODS: Forty nine patients with osteosarcoma were treated with preoperative chemotherapy with intra-arterial cisplatin and adriamycin infusion for 3 cycles, followed by surgery. According to the pathologic response, if tumor was necrotized more than 90%, the same adjuvant chemotherapy was reintroduced for 3 cycles, and if the response was not enough, then the salvage regimen was introduced. Plain chest film and chest CT scan were taken monthly and every 3 months, respectively. When tumor recurred, the metastasectomy was performed whenever possible. 0aRESULTS: Forty three patients were evaluable with amedian follow up of 53 months. Five-year disease-free and overallsurvival rate was 47.0% and 66.9%, respectively. The recurrence was observed in 22 patients (51.2%) with median time of 12.5 months. Baseline alkaline phosphatase (ALP) was the only significant factor for recurrence (pomths vs 5~12 months).0aCONCLUSION: These results indicates that pre- and postoperative chemotherapy with intra-arterial cisplatin and adriamycin infusion showed comparable treatment efficacy and acceptable toxicities.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/142278
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Pathology
1. 연구논문 > 1. College of Medicine > Dept. of Surgery
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
1. 연구논문 > 5. Research Institutes > Cancer Metastasis Research Center
1. 연구논문 > 1. College of Medicine > Dept. of Orthopedic Surgery
Yonsei Authors
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