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류마티스양 관절염 환자 활막 T 세포의 T 세포수용체 β 쇄 분석

Authors
 권대호 ; 이수곤 ; 최인홍 ; 김세종 
Citation
 Immune Network, Vol.1(1) : 70~76, 2001 
Journal Title
 Immune Network 
ISSN
 1598-2629 
Issue Date
2001
Abstract
Background: Rheumatoid arthritis is an autoimmune disease characterized by a chronic inflammatory process, primarily involving the synovial membrane of peripheral joints, where T cell activation is found. To address the superantigen stimulation in rheumatoid arthritis, T cell clonality and the expression of activation markers were analyzed. Methods: To detect TCRB V usage, inverse PCR and sequencing were done. Monoclonal antibodies were used for flow cytometric analysis of TCRBV8 or TCRBV5. As result s, a restricted usage of TCRBV3 gene was detected in synovial lymphocytes from one rheumatoid arthritis patient . However, preferential usage for TCRB V8, which may be one indicator for stimulation by staphylococcal superantigen, was not obvious although general activation of T cells was found as high DR+ percentage in synovial T cells. These data show specific antigen rather than superantigen might involve the pathogenesis of rheumatoid arthritis
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/142061
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Microbiology
Yonsei Authors
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