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류마티스양 관절염 환자 활막 T 세포의 T 세포수용체 β 쇄 분석

Authors
 권대호  ;  이수곤  ;  김세종  ;  최인홍 
Citation
 IMMUNE NETWORK, Vol.1(1) : 70-76, 2001 
Journal Title
 IMMUNE NETWORK 
ISSN
 1598-2629 
Issue Date
2001
Keywords
류마티스양 관절염 ; 관절활막 ; T 세포수용체 β Chain
Abstract
Background: Rheumatoid arthritis is an autoimmune disease characterized by a chronic inflammatory process, primarily involving the synovial membrane of peripheral joints, where T cell activation is found. To address the superantigen stimulation in rheumatoid arthritis, T cell clonality and the expression of activation markers were analyzed. Methods: To detect TCRB V usage, inverse PCR and sequencing were done. Monoclonal antibodies were used for flow cytometric analysis of TCRBV8 or TCRBV5. As result s, a restricted usage of TCRBV3 gene was detected in synovial lymphocytes from one rheumatoid arthritis patient . However, preferential usage for TCRB V8, which may be one indicator for stimulation by staphylococcal superantigen, was not obvious although general activation of T cells was found as high DR+ percentage in synovial T cells. These data show specific antigen rather than superantigen might involve the pathogenesis of rheumatoid arthritis
Files in This Item:
T200101526.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Se Jong(김세종)
Choi, In Hong(최인홍) ORCID logo https://orcid.org/0000-0001-9851-0137
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/142061
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