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류마티스양 관절염 환자 활막 T 세포의 T 세포수용체 β 쇄 분석
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김세종 | - |
dc.contributor.author | 최인홍 | - |
dc.date.accessioned | 2016-02-19T10:57:04Z | - |
dc.date.available | 2016-02-19T10:57:04Z | - |
dc.date.issued | 2001 | - |
dc.identifier.issn | 1598-2629 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/142061 | - |
dc.description.abstract | Background: Rheumatoid arthritis is an autoimmune disease characterized by a chronic inflammatory process, primarily involving the synovial membrane of peripheral joints, where T cell activation is found. To address the superantigen stimulation in rheumatoid arthritis, T cell clonality and the expression of activation markers were analyzed. Methods: To detect TCRB V usage, inverse PCR and sequencing were done. Monoclonal antibodies were used for flow cytometric analysis of TCRBV8 or TCRBV5. As result s, a restricted usage of TCRBV3 gene was detected in synovial lymphocytes from one rheumatoid arthritis patient . However, preferential usage for TCRB V8, which may be one indicator for stimulation by staphylococcal superantigen, was not obvious although general activation of T cells was found as high DR+ percentage in synovial T cells. These data show specific antigen rather than superantigen might involve the pathogenesis of rheumatoid arthritis | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 70~76 | - |
dc.language | English | - |
dc.publisher | Korea Society for Immunology : Korean Society of Biological Response Modifiers | - |
dc.relation.isPartOf | IMMUNE NETWORK | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 류마티스양 관절염 환자 활막 T 세포의 T 세포수용체 β 쇄 분석 | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Microbiology (미생물학) | - |
dc.contributor.googleauthor | 권대호 | - |
dc.contributor.googleauthor | 이수곤 | - |
dc.contributor.googleauthor | 김세종 | - |
dc.contributor.googleauthor | 최인홍 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00603 | - |
dc.contributor.localId | A04167 | - |
dc.relation.journalcode | J01033 | - |
dc.identifier.eissn | 2092-6685 | - |
dc.subject.keyword | 류마티스양 관절염 | - |
dc.subject.keyword | 관절활막 | - |
dc.subject.keyword | T 세포수용체 β Chain | - |
dc.contributor.alternativeName | Kim, Se Jong | - |
dc.contributor.alternativeName | Choi, In Hong | - |
dc.contributor.affiliatedAuthor | Kim, Se Jong | - |
dc.contributor.affiliatedAuthor | Choi, In Hong | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 1 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 70 | - |
dc.citation.endPage | 76 | - |
dc.identifier.bibliographicCitation | IMMUNE NETWORK, Vol.1(1) : 70-76, 2001 | - |
dc.identifier.rimsid | 31571 | - |
dc.type.rims | ART | - |
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