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Validating of the pre-clinical mouse model for metastatic breast cancer to the mandible

Authors
 Young Sun HWANG  ;  Sang-Sun HAN  ;  Ki-Rim KIM  ;  Ye-Jin LEE  ;  Sun-Kyung LEE  ;  Kwang-Kyun PARK  ;  Won-Yoon CHUNG 
Citation
 JOURNAL OF APPLIED ORAL SCIENCE, Vol.23(1) : 3-8, 2015 
Journal Title
 JOURNAL OF APPLIED ORAL SCIENCE 
ISSN
 1678-7757 
Issue Date
2015
MeSH
Animals ; Breast Neoplasms/pathology* ; Carcinoma/secondary* ; Cells, Cultured ; Disease Models, Animal* ; Female ; Humans ; Imaging, Three-Dimensional ; Injections, Intramuscular ; Luciferases ; Luminescent Measurements ; Mandible/diagnostic imaging ; Mandible/pathology ; Mandibular Neoplasms/diagnostic imaging ; Mandibular Neoplasms/secondary* ; Mice, Inbred BALB C ; Reproducibility of Results ; Time Factors ; Tomography, X-Ray Computed
Keywords
Breast cancer ; Mandible ; Osteolysis ; Xenograft ; Luminescence
Abstract
Metastatic breast carcinoma has a great tendency to spread to the mandible. It is concomitantly associated with bone destruction, food intake disorder, and a poorer prognosis. Appropriate animal models need to be developed for a better understanding of the mechanisms underlying the metastatic process of breast cancer cells to mandible and to test the effects of potential lead compounds. Here, we assessed the metastasis model of intracardiac injection using luciferase-transfected metastatic breast cancer cells (MDA-MB-231Luc+) by determining the incidences of metastasis, mCT images, and histopathological results. A high bioluminescence signal mainly detected mandibular lesions with less frequent distal femora and proximal tibiae lesions. Extensive mandibular bone destruction occurred in nude mice grafted with metastatic breast cancer cells. This type of animal model might be a useful tool in assessing therapeutic implications and the efficacy of anti-cancer drugs for osteolytic cancers.
Files in This Item:
T201504239.pdf Download
DOI
10.1590/1678-775720140158
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Radiology (영상치의학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Park, Kwang Kyun(박광균)
Lee, Sun Kyoung(이선경) ORCID logo https://orcid.org/0000-0002-3707-8050
Chung, Won Yoon(정원윤) ORCID logo https://orcid.org/0000-0001-8428-9005
Han, Sang Sun(한상선) ORCID logo https://orcid.org/0000-0003-1775-7862
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/141749
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