265 360

Cited 1 times in

Validating of the pre-clinical mouse model for metastatic breast cancer to the mandible

DC FieldValueLanguage
dc.contributor.author박광균-
dc.contributor.author이선경-
dc.contributor.author정원윤-
dc.contributor.author한상선-
dc.date.accessioned2016-02-04T12:02:13Z-
dc.date.available2016-02-04T12:02:13Z-
dc.date.issued2015-
dc.identifier.issn1678-7757-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/141749-
dc.description.abstractMetastatic breast carcinoma has a great tendency to spread to the mandible. It is concomitantly associated with bone destruction, food intake disorder, and a poorer prognosis. Appropriate animal models need to be developed for a better understanding of the mechanisms underlying the metastatic process of breast cancer cells to mandible and to test the effects of potential lead compounds. Here, we assessed the metastasis model of intracardiac injection using luciferase-transfected metastatic breast cancer cells (MDA-MB-231Luc+) by determining the incidences of metastasis, mCT images, and histopathological results. A high bioluminescence signal mainly detected mandibular lesions with less frequent distal femora and proximal tibiae lesions. Extensive mandibular bone destruction occurred in nude mice grafted with metastatic breast cancer cells. This type of animal model might be a useful tool in assessing therapeutic implications and the efficacy of anti-cancer drugs for osteolytic cancers.-
dc.description.statementOfResponsibilityopen-
dc.format.extent3~8-
dc.relation.isPartOfJOURNAL OF APPLIED ORAL SCIENCE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHBreast Neoplasms/pathology*-
dc.subject.MESHCarcinoma/secondary*-
dc.subject.MESHCells, Cultured-
dc.subject.MESHDisease Models, Animal*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHImaging, Three-Dimensional-
dc.subject.MESHInjections, Intramuscular-
dc.subject.MESHLuciferases-
dc.subject.MESHLuminescent Measurements-
dc.subject.MESHMandible/diagnostic imaging-
dc.subject.MESHMandible/pathology-
dc.subject.MESHMandibular Neoplasms/diagnostic imaging-
dc.subject.MESHMandibular Neoplasms/secondary*-
dc.subject.MESHMice, Inbred BALB C-
dc.subject.MESHReproducibility of Results-
dc.subject.MESHTime Factors-
dc.subject.MESHTomography, X-Ray Computed-
dc.titleValidating of the pre-clinical mouse model for metastatic breast cancer to the mandible-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Oral and Maxillofacial Radiology (구강악안면방사선과학)-
dc.contributor.googleauthorYoung Sun HWANG-
dc.contributor.googleauthorSang-Sun HAN-
dc.contributor.googleauthorKi-Rim KIM-
dc.contributor.googleauthorYe-Jin LEE-
dc.contributor.googleauthorSun-Kyung LEE-
dc.contributor.googleauthorKwang-Kyun PARK-
dc.contributor.googleauthorWon-Yoon CHUNG-
dc.identifier.doi10.1590/1678-775720140158-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01429-
dc.contributor.localIdA02854-
dc.contributor.localIdA03676-
dc.contributor.localIdA04283-
dc.relation.journalcodeJ01240-
dc.identifier.eissn1678-7765-
dc.identifier.pmid25760261-
dc.subject.keywordBreast cancer-
dc.subject.keywordMandible-
dc.subject.keywordOsteolysis-
dc.subject.keywordXenograft-
dc.subject.keywordLuminescence-
dc.contributor.alternativeNamePark, Kwang Kyun-
dc.contributor.alternativeNameLee, Seon Kyung-
dc.contributor.alternativeNameChung, Won Yoon-
dc.contributor.alternativeNameHan, Sang Sun-
dc.contributor.affiliatedAuthorPark, Kwang Kyun-
dc.contributor.affiliatedAuthorLee, Seon Kyung-
dc.contributor.affiliatedAuthorChung, Won Yoon-
dc.contributor.affiliatedAuthorHan, Sang Sun-
dc.rights.accessRightsfree-
dc.citation.volume23-
dc.citation.number1-
dc.citation.startPage3-
dc.citation.endPage8-
dc.identifier.bibliographicCitationJOURNAL OF APPLIED ORAL SCIENCE, Vol.23(1) : 3-8, 2015-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Radiology (영상치의학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.