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Value of utilizing both ASPECTS and CT angiography collateral score for outcome prediction in acute ischemic stroke

Authors
 Dongbeom Song  ;  Kijeong Lee  ;  Eun Hye Kim  ;  Young Dae Kim  ;  Jinkwon Kim  ;  Tae-Jin Song  ;  Hye Sun Lee  ;  Hyo Suk Nam  ;  Ji Hoe Heo 
Citation
 INTERNATIONAL JOURNAL OF STROKE, Vol.10(7) : 1018-1023, 2015 
Journal Title
 INTERNATIONAL JOURNAL OF STROKE 
ISSN
 1747-4930 
Issue Date
2015
MeSH
Aged ; Aged, 80 and over ; Brain Ischemia/complications* ; Cerebral Angiography ; Collateral Circulation ; Female ; Humans ; Male ; Middle Aged ; ROC Curve ; Regression Analysis ; Reperfusion ; Retrospective Studies ; Stroke/diagnostic imaging* ; Stroke/etiology* ; Stroke/therapy ; Tomography, X-Ray Computed/methods* ; Treatment Outcome
Keywords
ASPECTS ; CT angiography ; acute stroke therapy ; collateral ; thrombectomy ; thrombolysis
Abstract
BACKGROUND: Alberta Stroke Program Early CT Score (ASPECTS) represents the extent of irreversibly damaged tissue; while CT angiography collateral score (CTA-CS) denotes the degree of collaterals. AIMS: We investigated whether there is cumulative value in using both ASPECTS and CTA-CS for outcome prediction and attempted to determine the specific subgroup of patients who could benefit from successful reperfusion using these scores. METHODS: This is a retrospective observational study of stroke patients treated with intra-arterial reperfusion therapy for unilateral arterial occlusion in the anterior circulation. A favorable outcome was defined as modified Rankin Scale ≤ 2 at three-months. Receiver operating characteristic comparison analysis was performed to decide whether outcome predictability increases when ASPECTS and CTA-CS are used together. Classification and regression tree (CART) analysis was done to identify the variables that best predict outcome and define the specific subgroup of patients who could benefit from successful reperfusion. RESULTS: A total of 91 consecutive patients were included. Outcome predictability of ASPECTS with CTA-CS was better than that of ASPECTS (P = 0·088) or that of CTA-CS (P = 0·049). CART analysis revealed that ASPECTS > 5 was the primary determinant of favorable outcome, followed by CTA-CS > 1. Among 19 patients with ASPECTS ≤ 5, none had a favorable outcome. Successful reperfusion was associated significantly with favorable outcome in the 51 patients with ASPECTS > 5 and CTA-CS > 1, but not in the 21 patients with ASPECTS > 5 and CTA-CS ≤ 1. CONCLUSIONS: Outcome predictability improves when using ASPECTS and CTA-CS together.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/ijs.12505/abstract
DOI
10.1111/ijs.12505
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kim, Young Dae(김영대) ORCID logo https://orcid.org/0000-0001-5750-2616
Kim, Eun Hye(김은혜)
Kim, Jinkwon(김진권) ORCID logo https://orcid.org/0000-0003-0156-9736
Nam, Hyo Suk(남효석) ORCID logo https://orcid.org/0000-0002-4415-3995
Song, Dong Beom(송동범)
Song, Tae Jin(송태진)
Lee, Ki Jeong(이기정)
Lee, Hye Sun(이혜선) ORCID logo https://orcid.org/0000-0001-6328-6948
Heo, Ji Hoe(허지회) ORCID logo https://orcid.org/0000-0001-9898-3321
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/141614
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