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성인 뇌성마비 환자에서 경막내 바클로펜 주입 후 용량 의존적 보행 양상 변화

Other Titles
 Dose-dependent Changes in Gait Pattern after Intrathecal Baclofen Bolus Injection in Adult Ambulatory Cerebral Palsy ?A Case Report? 
 신윤겸  ;  김애령  ;  장진우  ;  장원석  ;  이돈신  ;  조성래 
 Brain & Neurorehabilitation, Vol.8(2) : 104-108, 2015 
Journal Title
Brain & Neurorehabilitation
Issue Date
baclofen ; cerebral palsy ; gait
Intrathecal baclofen (ITB) therapy has been proven to reduce severe spasticity in cerebral palsy (CP). However, few results reported the objective gait pattern change after ITB bolus injection in adult ambulatory CP. We therefore evaluated observational and kinematic gait patterns at different ITB bolus injection doses. We performed a test trial of 3-day ITB bolus injections at doses of 12.5 µg, 25 µg, and 50 µg in ambulatory CP. We evaluated modified Ashworth scale, visual analogue scale, observational gait scale, and kinematic gait analysis after ITB bolus injection. Intrathecal administration of low-dose baclofen 25 µg was successfully used not only for the treatment of spasticity but also for the treatment of gait disturbance, whereas the higher dose baclofen 50 µg induced foot drop and deteriorated gait pattern. We experienced dose-dependent changes in gait pattern confirmed by the observational and kinematic gait assessments after ITB bolus injection in adult ambulatory CP.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kim, Ae Ryoung(김애령)
Shin, Yoon Kyum(신윤겸) ORCID logo https://orcid.org/0000-0001-5461-660X
Chang, Won Seok(장원석) ORCID logo https://orcid.org/0000-0003-3145-4016
Chang, Jin Woo(장진우) ORCID logo https://orcid.org/0000-0002-2717-0101
Cho, Sung-Rae(조성래) ORCID logo https://orcid.org/0000-0003-1429-2684
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