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성인 뇌성마비 환자에서 경막내 바클로펜 주입 후 용량 의존적 보행 양상 변화

Other Titles
 Dose-dependent Changes in Gait Pattern after Intrathecal Baclofen Bolus Injection in Adult Ambulatory Cerebral Palsy ?A Case Report? 
Authors
 신윤겸  ;  김애령  ;  장진우  ;  장원석  ;  이돈신  ;  조성래 
Citation
 Brain & Neurorehabilitation, Vol.8(2) : 104-108, 2015 
Journal Title
 Brain & Neurorehabilitation 
ISSN
 1976-8753 
Issue Date
2015
Abstract
Intrathecal baclofen (ITB) therapy has been proven to reduce severe spasticity in cerebral palsy (CP). However, few results reported the objective gait pattern change after ITB bolus injection in adult ambulatory CP. We therefore evaluated observational and kinematic gait patterns at different ITB bolus injection doses. We performed a test trial of 3-day ITB bolus injections at doses of 12.5 µg, 25 µg, and 50 µg in ambulatory CP. We evaluated modified Ashworth scale, visual analogue scale, observational gait scale, and kinematic gait analysis after ITB bolus injection. Intrathecal administration of low-dose baclofen 25 µg was successfully used not only for the treatment of spasticity but also for the treatment of gait disturbance, whereas the higher dose baclofen 50 µg induced foot drop and deteriorated gait pattern. We experienced dose-dependent changes in gait pattern confirmed by the observational and kinematic gait assessments after ITB bolus injection in adult ambulatory CP.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/141421
DOI
10.12786/bn.2015.8.2.104
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원)
Yonsei Authors
김애령(Kim, Ae Ryoung)
신윤겸(Shin, Yoon Kyum)
장원석(Chang, Won Seok)
장진우(Chang, Jin Woo)
조성래(Cho, Sung Rae)
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