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Clinical Trial of Human Fetal Brain-Derived Neural Stem/Progenitor Cell Transplantation in Patients with Traumatic Cervical Spinal Cord Injury

 Ji Cheol Shin  ;  Keung Nyun Kim  ;  Jeehyun Yoo  ;  Il-Sun Kim  ;  Seokhwan Yun  ;  Hyejin Lee  ;  Kwangsoo Jung  ;  Kyujin Hwang  ;  Miri Kim  ;  Il-Shin Lee  ;  Jeong Eun Shin  ;  Kook In Park 
 NEURAL PLASTICITY, Vol.2015 : 630932, 2015 
Journal Title
Issue Date
Adolescent ; Adult ; Cervical Cord/injuries* ; Female ; Fetal Stem Cells/transplantation* ; Humans ; Lower Extremity/innervation ; Lower Extremity/physiopathology ; Male ; Middle Aged ; Motor Activity ; Muscle Spasticity ; Neural Conduction ; Neural Stem Cells/transplantation* ; Pain Measurement ; Spinal Cord Injuries/pathology ; Spinal Cord Injuries/rehabilitation* ; Spinal Cord Injuries/therapy* ; Stem Cell Transplantation/adverse effects* ; Treatment Outcome ; Upper Extremity/innervation ; Upper Extremity/physiopathology ; Young Adult
In a phase I/IIa open-label and nonrandomized controlled clinical trial, we sought to assess the safety and neurological effects of human neural stem/progenitor cells (hNSPCs) transplanted into the injured cord after traumatic cervical spinal cord injury (SCI). Of 19 treated subjects, 17 were sensorimotor complete and 2 were motor complete and sensory incomplete. hNSPCs derived from the fetal telencephalon were grown as neurospheres and transplanted into the cord. In the control group, who did not receive cell implantation but were otherwise closely matched with the transplantation group, 15 patients with traumatic cervical SCI were included. At 1 year after cell transplantation, there was no evidence of cord damage, syrinx or tumor formation, neurological deterioration, and exacerbating neuropathic pain or spasticity. The American Spinal Injury Association Impairment Scale (AIS) grade improved in 5 of 19 transplanted patients, 2 (A → C), 1 (A → B), and 2 (B → D), whereas only one patient in the control group showed improvement (A → B). Improvements included increased motor scores, recovery of motor levels, and responses to electrophysiological studies in the transplantation group. Therefore, the transplantation of hNSPCs into cervical SCI is safe and well-tolerated and is of modest neurological benefit up to 1 year after transplants. This trial is registered with Clinical Research Information Service (CRIS), Registration Number: KCT0000879.
Appears in Collections:
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Keung Nyun(김긍년)
Kim, Mi Ri(김미리)
Kim, Il-Sun(김일선) ORCID logo https://orcid.org/0000-0003-4033-4323
Park, Kook In(박국인) ORCID logo https://orcid.org/0000-0001-8499-9293
Shin, Jeong Eun(신정은) ORCID logo https://orcid.org/0000-0002-4376-8541
Shin, Ji Cheol(신지철) ORCID logo https://orcid.org/0000-0002-1133-1361
Yoo, Jee Hyun(유지현)
Yun, Seok Hwan(윤석환)
Jung, Kwang Soo(정광수) ORCID logo https://orcid.org/0000-0001-7365-7247
Hwang, Kyujin(황규진) ORCID logo https://orcid.org/0000-0001-5193-5154
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