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Clinical Trial of Human Fetal Brain-Derived Neural Stem/Progenitor Cell Transplantation in Patients with Traumatic Cervical Spinal Cord Injury

Authors
 Ji Cheol Shin  ;  Keung Nyun Kim  ;  Jeehyun Yoo  ;  Il-Sun Kim  ;  Seokhwan Yun  ;  Hyejin Lee  ;  Kwangsoo Jung  ;  Kyujin Hwang  ;  Miri Kim  ;  Il-Shin Lee  ;  Jeong Eun Shin  ;  Kook In Park 
Citation
 Neural Plasticity, Vol.2015 : 630932-630932, 2015 
Journal Title
 Neural Plasticity 
ISSN
 2090-5904 
Issue Date
2015
Abstract
In a phase I/IIa open-label and nonrandomized controlled clinical trial, we sought to assess the safety and neurological effects of human neural stem/progenitor cells (hNSPCs) transplanted into the injured cord after traumatic cervical spinal cord injury (SCI). Of 19 treated subjects, 17 were sensorimotor complete and 2 were motor complete and sensory incomplete. hNSPCs derived from the fetal telencephalon were grown as neurospheres and transplanted into the cord. In the control group, who did not receive cell implantation but were otherwise closely matched with the transplantation group, 15 patients with traumatic cervical SCI were included. At 1 year after cell transplantation, there was no evidence of cord damage, syrinx or tumor formation, neurological deterioration, and exacerbating neuropathic pain or spasticity. The American Spinal Injury Association Impairment Scale (AIS) grade improved in 5 of 19 transplanted patients, 2 (A → C), 1 (A → B), and 2 (B → D), whereas only one patient in the control group showed improvement (A → B). Improvements included increased motor scores, recovery of motor levels, and responses to electrophysiological studies in the transplantation group. Therefore, the transplantation of hNSPCs into cervical SCI is safe and well-tolerated and is of modest neurological benefit up to 1 year after transplants. This trial is registered with Clinical Research Information Service (CRIS), Registration Number: KCT0000879.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/141355
DOI
10.1155/2015/630932
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학교실)
Yonsei Authors
김긍년(Kim, Keung Nyun) ; 김미리(Kim, Mi Ri) ; 박국인(Park, Kook In) ; 신정은(Shin, Jeong Eun) ; 신지철(Shin, Ji Cheol) ; 유지현(Yoo, Jee Hyun) ; 윤석환(Yun, Seok Hwan) ; 정광수(Jung, Kwang Soo) ; 황규진(Hwang, Kyu Jin)
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