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Clinical Trial of Human Fetal Brain-Derived Neural Stem/Progenitor Cell Transplantation in Patients with Traumatic Cervical Spinal Cord Injury

DC FieldValueLanguage
dc.contributor.author김긍년-
dc.contributor.author김미리-
dc.contributor.author박국인-
dc.contributor.author신정은-
dc.contributor.author신지철-
dc.contributor.author유지현-
dc.contributor.author윤석환-
dc.contributor.author정광수-
dc.contributor.author황규진-
dc.contributor.author김일선-
dc.date.accessioned2016-02-04T11:51:26Z-
dc.date.available2016-02-04T11:51:26Z-
dc.date.issued2015-
dc.identifier.issn2090-5904-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/141355-
dc.description.abstractIn a phase I/IIa open-label and nonrandomized controlled clinical trial, we sought to assess the safety and neurological effects of human neural stem/progenitor cells (hNSPCs) transplanted into the injured cord after traumatic cervical spinal cord injury (SCI). Of 19 treated subjects, 17 were sensorimotor complete and 2 were motor complete and sensory incomplete. hNSPCs derived from the fetal telencephalon were grown as neurospheres and transplanted into the cord. In the control group, who did not receive cell implantation but were otherwise closely matched with the transplantation group, 15 patients with traumatic cervical SCI were included. At 1 year after cell transplantation, there was no evidence of cord damage, syrinx or tumor formation, neurological deterioration, and exacerbating neuropathic pain or spasticity. The American Spinal Injury Association Impairment Scale (AIS) grade improved in 5 of 19 transplanted patients, 2 (A → C), 1 (A → B), and 2 (B → D), whereas only one patient in the control group showed improvement (A → B). Improvements included increased motor scores, recovery of motor levels, and responses to electrophysiological studies in the transplantation group. Therefore, the transplantation of hNSPCs into cervical SCI is safe and well-tolerated and is of modest neurological benefit up to 1 year after transplants. This trial is registered with Clinical Research Information Service (CRIS), Registration Number: KCT0000879.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfNeural Plasticity-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleClinical Trial of Human Fetal Brain-Derived Neural Stem/Progenitor Cell Transplantation in Patients with Traumatic Cervical Spinal Cord Injury-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentYonsei Biomedical Research Center (연세의생명연구원)-
dc.contributor.googleauthorJi Cheol Shin-
dc.contributor.googleauthorKeung Nyun Kim-
dc.contributor.googleauthorJeehyun Yoo-
dc.contributor.googleauthorIl-Sun Kim-
dc.contributor.googleauthorSeokhwan Yun-
dc.contributor.googleauthorHyejin Lee-
dc.contributor.googleauthorKwangsoo Jung-
dc.contributor.googleauthorKyujin Hwang-
dc.contributor.googleauthorMiri Kim-
dc.contributor.googleauthorIl-Shin Lee-
dc.contributor.googleauthorJeong Eun Shin-
dc.contributor.googleauthorKook In Park-
dc.identifier.doi10.1155/2015/630932-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00331-
dc.contributor.localIdA00443-
dc.contributor.localIdA01438-
dc.contributor.localIdA02152-
dc.contributor.localIdA02162-
dc.contributor.localIdA02520-
dc.contributor.localIdA02565-
dc.contributor.localIdA03574-
dc.contributor.localIdA04455-
dc.relation.journalcodeJ02319-
dc.contributor.alternativeNameKim, Keung Nyun-
dc.contributor.alternativeNameKim, Mi Ri-
dc.contributor.alternativeNamePark, Kook In-
dc.contributor.alternativeNameShin, Jeong Eun-
dc.contributor.alternativeNameShin, Ji Cheol-
dc.contributor.alternativeNameYoo, Jee Hyun-
dc.contributor.alternativeNameYun, Seok Hwan-
dc.contributor.alternativeNameJung, Kwang Soo-
dc.contributor.alternativeNameHwang, Kyu Jin-
dc.contributor.affiliatedAuthorKim, Keung Nyun-
dc.contributor.affiliatedAuthorKim, Mi Ri-
dc.contributor.affiliatedAuthorPark, Kook In-
dc.contributor.affiliatedAuthorShin, Jeong Eun-
dc.contributor.affiliatedAuthorShin, Ji Cheol-
dc.contributor.affiliatedAuthorYoo, Jee Hyun-
dc.contributor.affiliatedAuthorYun, Seok Hwan-
dc.contributor.affiliatedAuthorJung, Kwang Soo-
dc.contributor.affiliatedAuthorHwang, Kyu Jin-
dc.rights.accessRightsnot available-
dc.citation.volume2015-
dc.citation.startPage630932-
dc.identifier.bibliographicCitationNeural Plasticity, Vol.2015 : 630932, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학교실) > 1. Journal Papers

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