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Acoustic Radiation Force Impulse Measurement in Renal Transplantation: A Prospective, Longitudinal Study With Protocol Biopsies

 Juhan Lee  ;  Young Taik Oh  ;  Dong Jin Joo  ;  Bo Gyoung Ma  ;  A-lan Lee  ;  Jae Geun Lee  ;  Seung Hwan Song  ;  Seung Up Kim  ;  Dae Chul Jung  ;  Yong Eun Chung  ;  Yu Seun Kim 
 Medicine, Vol.94(39) : 1590-1590, 2015 
Journal Title
Issue Date
Interstitial fibrosis and tubular atrophy (IF/TA) is a common cause of kidney allograft loss. Several noninvasive techniques developed to assess tissue fibrosis are widely used to examine the liver. However, relatively few studies have investigated the use of elastographic methods to assess transplanted kidneys. The aim of this study was to explore the clinical implications of the acoustic radiation force impulse (ARFI) technique in renal transplant patients. A total of 91 patients who underwent living donor renal transplantation between September 2010 and January 2013 were included in this prospective study. Shear wave velocity (SWV) was measured by ARFI at baseline and predetermined time points (1 week and 6 and 12 months after transplantation). Protocol biopsies were performed at 12 months. Instead of reflecting IF/TA, SWVs were found to be related to time elapsed after transplantation. Mean SWV increased continuously during the first postoperative year (P < 0.001). In addition, mixed model analysis showed no correlation existed between SWV and serum creatinine (r = -0.2426, P = 0.0771). There was also no evidence of a relationship between IF/TA and serum creatinine (odds ratio [OR] = 1.220, P = 0.7648). Furthermore, SWV temporal patterns were dependent on the kidney weight to body weight ratio (KW/BW). In patients with a KW/BW < 3.5 g/kg, mean SWV continuously increased for 12 months, whereas it decreased after 6 months in those with a KW/BW ≥ 3.5 g/kg.No significant correlation was observed between SWV and IF/TA or renal dysfunction. However, SWV was found to be related to the time after transplantation. Renal hemodynamics influenced by KW/BW might impact SWV values.
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
김승업(Kim, Seung Up) ORCID logo https://orcid.org/0000-0002-9658-8050
김유선(Kim, Yu Seun) ORCID logo https://orcid.org/0000-0002-5105-1567
마보경(Ma, Bo Gyoung)
송승환(Song, Seung Hwan)
오영택(Oh, Young Taik) ORCID logo https://orcid.org/0000-0002-4438-8890
이아란(Lee, A Lan)
이재근(Lee, Jae Geun) ORCID logo https://orcid.org/0000-0002-6722-0257
이주한(Lee, Ju Han)
정대철(Jung, Dae Chul) ORCID logo https://orcid.org/0000-0001-5769-5083
정용은(Chung, Yong Eun) ORCID logo https://orcid.org/0000-0003-0811-9578
주동진(Joo, Dong Jin) ORCID logo https://orcid.org/0000-0001-8405-1531
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