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Acoustic Radiation Force Impulse Measurement in Renal Transplantation: A Prospective, Longitudinal Study With Protocol Biopsies

 Juhan Lee  ;  Young Taik Oh  ;  Dong Jin Joo  ;  Bo Gyoung Ma  ;  A-lan Lee  ;  Jae Geun Lee  ;  Seung Hwan Song  ;  Seung Up Kim  ;  Dae Chul Jung  ;  Yong Eun Chung  ;  Yu Seun Kim 
 MEDICINE, Vol.94(39) : 1590, 2015 
Journal Title
Issue Date
Biopsy ; Elasticity Imaging Techniques/methods* ; Female ; Hemodynamics ; Humans ; Kidney/blood supply ; Kidney/pathology* ; Kidney Function Tests ; Kidney Transplantation/methods* ; Living Donors ; Longitudinal Studies ; Male ; Prospective Studies ; Pulse Wave Analysis ; Time Factors
Interstitial fibrosis and tubular atrophy (IF/TA) is a common cause of kidney allograft loss. Several noninvasive techniques developed to assess tissue fibrosis are widely used to examine the liver. However, relatively few studies have investigated the use of elastographic methods to assess transplanted kidneys. The aim of this study was to explore the clinical implications of the acoustic radiation force impulse (ARFI) technique in renal transplant patients. A total of 91 patients who underwent living donor renal transplantation between September 2010 and January 2013 were included in this prospective study. Shear wave velocity (SWV) was measured by ARFI at baseline and predetermined time points (1 week and 6 and 12 months after transplantation). Protocol biopsies were performed at 12 months. Instead of reflecting IF/TA, SWVs were found to be related to time elapsed after transplantation. Mean SWV increased continuously during the first postoperative year (P < 0.001). In addition, mixed model analysis showed no correlation existed between SWV and serum creatinine (r = -0.2426, P = 0.0771). There was also no evidence of a relationship between IF/TA and serum creatinine (odds ratio [OR] = 1.220, P = 0.7648). Furthermore, SWV temporal patterns were dependent on the kidney weight to body weight ratio (KW/BW). In patients with a KW/BW < 3.5 g/kg, mean SWV continuously increased for 12 months, whereas it decreased after 6 months in those with a KW/BW ≥ 3.5 g/kg.No significant correlation was observed between SWV and IF/TA or renal dysfunction. However, SWV was found to be related to the time after transplantation. Renal hemodynamics influenced by KW/BW might impact SWV values.
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1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Seung Up(김승업) ORCID logo https://orcid.org/0000-0002-9658-8050
Kim, Yu Seun(김유선) ORCID logo https://orcid.org/0000-0002-5105-1567
Ma, Bo Gyoung(마보경)
Song, Seung Hwan(송승환)
Oh, Young Taik(오영택) ORCID logo https://orcid.org/0000-0002-4438-8890
Lee, A Lan(이아란)
Lee, Jae Geun(이재근) ORCID logo https://orcid.org/0000-0002-6722-0257
Lee, Ju Han(이주한)
Jung, Dae Chul(정대철) ORCID logo https://orcid.org/0000-0001-5769-5083
Chung, Yong Eun(정용은) ORCID logo https://orcid.org/0000-0003-0811-9578
Joo, Dong Jin(주동진) ORCID logo https://orcid.org/0000-0001-8405-1531
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