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Acoustic Radiation Force Impulse Measurement in Renal Transplantation: A Prospective, Longitudinal Study With Protocol Biopsies

Authors
 Juhan Lee  ;  Young Taik Oh  ;  Dong Jin Joo  ;  Bo Gyoung Ma  ;  A-lan Lee  ;  Jae Geun Lee  ;  Seung Hwan Song  ;  Seung Up Kim  ;  Dae Chul Jung  ;  Yong Eun Chung  ;  Yu Seun Kim 
Citation
 Medicine, Vol.94(39) : 1590-1590, 2015 
Journal Title
 Medicine 
ISSN
 0025-7974 
Issue Date
2015
Abstract
Interstitial fibrosis and tubular atrophy (IF/TA) is a common cause of kidney allograft loss. Several noninvasive techniques developed to assess tissue fibrosis are widely used to examine the liver. However, relatively few studies have investigated the use of elastographic methods to assess transplanted kidneys. The aim of this study was to explore the clinical implications of the acoustic radiation force impulse (ARFI) technique in renal transplant patients. A total of 91 patients who underwent living donor renal transplantation between September 2010 and January 2013 were included in this prospective study. Shear wave velocity (SWV) was measured by ARFI at baseline and predetermined time points (1 week and 6 and 12 months after transplantation). Protocol biopsies were performed at 12 months. Instead of reflecting IF/TA, SWVs were found to be related to time elapsed after transplantation. Mean SWV increased continuously during the first postoperative year (P < 0.001). In addition, mixed model analysis showed no correlation existed between SWV and serum creatinine (r = -0.2426, P = 0.0771). There was also no evidence of a relationship between IF/TA and serum creatinine (odds ratio [OR] = 1.220, P = 0.7648). Furthermore, SWV temporal patterns were dependent on the kidney weight to body weight ratio (KW/BW). In patients with a KW/BW < 3.5 g/kg, mean SWV continuously increased for 12 months, whereas it decreased after 6 months in those with a KW/BW ≥ 3.5 g/kg.No significant correlation was observed between SWV and IF/TA or renal dysfunction. However, SWV was found to be related to the time after transplantation. Renal hemodynamics influenced by KW/BW might impact SWV values.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/141272
DOI
10.1097/MD.0000000000001590
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
김승업(Kim, Seung Up)
김유선(Kim, Yu Seun)
마보경(Ma, Bo Gyoung)
송승환(Song, Seung Hwan)
오영택(Oh, Young Taik)
이아란(Lee, A Lan)
이재근(Lee, Jae Geun)
이주한(Lee, Ju Han)
정대철(Jung, Dae Chul)
정용은(Chung, Yong Eun)
주동진(Joo, Dong Jin)
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