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BRAF mutation in fine-needle aspiration specimens as a potential predictor for persistence/recurrence in patients with classical papillary thyroid carcinoma larger than 10 mm at a BRAF mutation prevalent area

Authors
 Hee Jung Moon  ;  Eun-Kyung Kim  ;  Woong Youn Chung  ;  Dong Yeob Shin  ;  Jin Young Kwak 
Citation
 HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, Vol.37(10) : 1432-1438, 2015 
Journal Title
 HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK 
ISSN
 1043-3074 
Issue Date
2015
MeSH
Adult ; Aged ; Biopsy, Fine-Needle ; Carcinoma/diagnosis ; Carcinoma/genetics* ; Carcinoma/surgery ; Carcinoma, Papillary ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Multiplex Polymerase Chain Reaction ; Mutation* ; Neoplasm Recurrence, Local/diagnosis* ; Prevalence ; Proto-Oncogene Proteins B-raf/genetics* ; Thyroid Neoplasms/diagnosis ; Thyroid Neoplasms/genetics* ; Thyroid Neoplasms/surgery ; Thyroidectomy ; Young Adult
Keywords
BRAF mutation ;  papillary thyroid carcinoma ; prognosis ;  recurrence ;  thyroid
Abstract
BACKGROUND: The association between the BRAF mutation and persistence/recurrence was investigated in patients with classical papillary thyroid carcinoma (PTC) at a BRAF mutation prevalent area. METHODS: A total of 282 patients with total thyroidectomy and prophylactic central neck dissection were included in this study. The BRAF mutation was evaluated with cytology specimen using dual priming oligonucleotide (DPO)-based multiplex polymerase chain reaction (PCR) and direct sequencing preoperatively. RESULTS: Thirty-four patients (12%) had persistence/recurrence. In all PTC, the BRAF mutation on both methods was not associated with persistence/recurrence. In PTC >10 mm, the BRAF mutation on DPO-based multiplex PCR was significantly associated with persistence/recurrence and a potential predictor for persistence/recurrence. In PTC ≤10 mm, none of the covariates were significantly different between patients with and without persistence/recurrence. CONCLUSION: The BRAF mutation was significantly associated with persistence/recurrence and a potential predictor in patients with classical PTC >10 mm at a BRAF mutation prevalent area.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/hed.23770/abstract
DOI
10.1002/hed.23770
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kwak, Jin Young(곽진영) ORCID logo https://orcid.org/0000-0002-6212-1495
Kim, Eun-Kyung(김은경) ORCID logo https://orcid.org/0000-0002-3368-5013
Moon, Hee Jung(문희정) ORCID logo https://orcid.org/0000-0002-5643-5885
Shin, Dong Yeob(신동엽) ORCID logo https://orcid.org/0000-0003-1048-7978
Chung, Woung Youn(정웅윤)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/141142
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