Cited 10 times in
BRAF mutation in fine-needle aspiration specimens as a potential predictor for persistence/recurrence in patients with classical papillary thyroid carcinoma larger than 10 mm at a BRAF mutation prevalent area
DC Field | Value | Language |
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dc.contributor.author | 곽진영 | - |
dc.contributor.author | 김은경 | - |
dc.contributor.author | 문희정 | - |
dc.contributor.author | 신동엽 | - |
dc.contributor.author | 정웅윤 | - |
dc.date.accessioned | 2016-02-04T11:45:41Z | - |
dc.date.available | 2016-02-04T11:45:41Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1043-3074 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/141142 | - |
dc.description.abstract | BACKGROUND: The association between the BRAF mutation and persistence/recurrence was investigated in patients with classical papillary thyroid carcinoma (PTC) at a BRAF mutation prevalent area. METHODS: A total of 282 patients with total thyroidectomy and prophylactic central neck dissection were included in this study. The BRAF mutation was evaluated with cytology specimen using dual priming oligonucleotide (DPO)-based multiplex polymerase chain reaction (PCR) and direct sequencing preoperatively. RESULTS: Thirty-four patients (12%) had persistence/recurrence. In all PTC, the BRAF mutation on both methods was not associated with persistence/recurrence. In PTC >10 mm, the BRAF mutation on DPO-based multiplex PCR was significantly associated with persistence/recurrence and a potential predictor for persistence/recurrence. In PTC ≤10 mm, none of the covariates were significantly different between patients with and without persistence/recurrence. CONCLUSION: The BRAF mutation was significantly associated with persistence/recurrence and a potential predictor in patients with classical PTC >10 mm at a BRAF mutation prevalent area. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1432~1438 | - |
dc.relation.isPartOf | HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Biopsy, Fine-Needle | - |
dc.subject.MESH | Carcinoma/diagnosis | - |
dc.subject.MESH | Carcinoma/genetics* | - |
dc.subject.MESH | Carcinoma/surgery | - |
dc.subject.MESH | Carcinoma, Papillary | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Multiplex Polymerase Chain Reaction | - |
dc.subject.MESH | Mutation* | - |
dc.subject.MESH | Neoplasm Recurrence, Local/diagnosis* | - |
dc.subject.MESH | Prevalence | - |
dc.subject.MESH | Proto-Oncogene Proteins B-raf/genetics* | - |
dc.subject.MESH | Thyroid Neoplasms/diagnosis | - |
dc.subject.MESH | Thyroid Neoplasms/genetics* | - |
dc.subject.MESH | Thyroid Neoplasms/surgery | - |
dc.subject.MESH | Thyroidectomy | - |
dc.subject.MESH | Young Adult | - |
dc.title | BRAF mutation in fine-needle aspiration specimens as a potential predictor for persistence/recurrence in patients with classical papillary thyroid carcinoma larger than 10 mm at a BRAF mutation prevalent area | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Hee Jung Moon | - |
dc.contributor.googleauthor | Eun-Kyung Kim | - |
dc.contributor.googleauthor | Woong Youn Chung | - |
dc.contributor.googleauthor | Dong Yeob Shin | - |
dc.contributor.googleauthor | Jin Young Kwak | - |
dc.identifier.doi | 10.1002/hed.23770 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00182 | - |
dc.contributor.localId | A00801 | - |
dc.contributor.localId | A01397 | - |
dc.contributor.localId | A02093 | - |
dc.contributor.localId | A03674 | - |
dc.relation.journalcode | J00963 | - |
dc.identifier.eissn | 1097-0347 | - |
dc.identifier.pmid | 24838814 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1002/hed.23770/abstract | - |
dc.subject.keyword | BRAFmutation | - |
dc.subject.keyword | papillarythyroidcarcinoma | - |
dc.subject.keyword | prognosis | - |
dc.subject.keyword | recurrence | - |
dc.subject.keyword | thyroid | - |
dc.contributor.alternativeName | Kwak, Jin Young | - |
dc.contributor.alternativeName | Kim, Eun Kyung | - |
dc.contributor.alternativeName | Moon, Heui Jeong | - |
dc.contributor.alternativeName | Shin, Dong Yeob | - |
dc.contributor.alternativeName | Chung, Woung Youn | - |
dc.contributor.affiliatedAuthor | Kwak, Jin Young | - |
dc.contributor.affiliatedAuthor | Kim, Eun-Kyung | - |
dc.contributor.affiliatedAuthor | Moon, Heui Jeong | - |
dc.contributor.affiliatedAuthor | Shin, Dong Yeob | - |
dc.contributor.affiliatedAuthor | Chung, Woung Youn | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 37 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1432 | - |
dc.citation.endPage | 1438 | - |
dc.identifier.bibliographicCitation | HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, Vol.37(10) : 1432-1438, 2015 | - |
dc.identifier.rimsid | 30541 | - |
dc.type.rims | ART | - |
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