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BRAF mutation in fine-needle aspiration specimens as a potential predictor for persistence/recurrence in patients with classical papillary thyroid carcinoma larger than 10 mm at a BRAF mutation prevalent area

DC Field Value Language
dc.contributor.author곽진영-
dc.contributor.author김은경-
dc.contributor.author문희정-
dc.contributor.author신동엽-
dc.contributor.author정웅윤-
dc.date.accessioned2016-02-04T11:45:41Z-
dc.date.available2016-02-04T11:45:41Z-
dc.date.issued2015-
dc.identifier.issn1043-3074-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/141142-
dc.description.abstractBACKGROUND: The association between the BRAF mutation and persistence/recurrence was investigated in patients with classical papillary thyroid carcinoma (PTC) at a BRAF mutation prevalent area. METHODS: A total of 282 patients with total thyroidectomy and prophylactic central neck dissection were included in this study. The BRAF mutation was evaluated with cytology specimen using dual priming oligonucleotide (DPO)-based multiplex polymerase chain reaction (PCR) and direct sequencing preoperatively. RESULTS: Thirty-four patients (12%) had persistence/recurrence. In all PTC, the BRAF mutation on both methods was not associated with persistence/recurrence. In PTC >10 mm, the BRAF mutation on DPO-based multiplex PCR was significantly associated with persistence/recurrence and a potential predictor for persistence/recurrence. In PTC ≤10 mm, none of the covariates were significantly different between patients with and without persistence/recurrence. CONCLUSION: The BRAF mutation was significantly associated with persistence/recurrence and a potential predictor in patients with classical PTC >10 mm at a BRAF mutation prevalent area.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1432~1438-
dc.relation.isPartOfHEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHBiopsy, Fine-Needle-
dc.subject.MESHCarcinoma/diagnosis-
dc.subject.MESHCarcinoma/genetics*-
dc.subject.MESHCarcinoma/surgery-
dc.subject.MESHCarcinoma, Papillary-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMultiplex Polymerase Chain Reaction-
dc.subject.MESHMutation*-
dc.subject.MESHNeoplasm Recurrence, Local/diagnosis*-
dc.subject.MESHPrevalence-
dc.subject.MESHProto-Oncogene Proteins B-raf/genetics*-
dc.subject.MESHThyroid Neoplasms/diagnosis-
dc.subject.MESHThyroid Neoplasms/genetics*-
dc.subject.MESHThyroid Neoplasms/surgery-
dc.subject.MESHThyroidectomy-
dc.subject.MESHYoung Adult-
dc.titleBRAF mutation in fine-needle aspiration specimens as a potential predictor for persistence/recurrence in patients with classical papillary thyroid carcinoma larger than 10 mm at a BRAF mutation prevalent area-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorHee Jung Moon-
dc.contributor.googleauthorEun-Kyung Kim-
dc.contributor.googleauthorWoong Youn Chung-
dc.contributor.googleauthorDong Yeob Shin-
dc.contributor.googleauthorJin Young Kwak-
dc.identifier.doi10.1002/hed.23770-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00182-
dc.contributor.localIdA00801-
dc.contributor.localIdA01397-
dc.contributor.localIdA02093-
dc.contributor.localIdA03674-
dc.relation.journalcodeJ00963-
dc.identifier.eissn1097-0347-
dc.identifier.pmid24838814-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1002/hed.23770/abstract-
dc.subject.keywordBRAFmutation-
dc.subject.keywordpapillarythyroidcarcinoma-
dc.subject.keywordprognosis-
dc.subject.keywordrecurrence-
dc.subject.keywordthyroid-
dc.contributor.alternativeNameKwak, Jin Young-
dc.contributor.alternativeNameKim, Eun Kyung-
dc.contributor.alternativeNameMoon, Heui Jeong-
dc.contributor.alternativeNameShin, Dong Yeob-
dc.contributor.alternativeNameChung, Woung Youn-
dc.contributor.affiliatedAuthorKwak, Jin Young-
dc.contributor.affiliatedAuthorKim, Eun-Kyung-
dc.contributor.affiliatedAuthorMoon, Heui Jeong-
dc.contributor.affiliatedAuthorShin, Dong Yeob-
dc.contributor.affiliatedAuthorChung, Woung Youn-
dc.rights.accessRightsnot free-
dc.citation.volume37-
dc.citation.number10-
dc.citation.startPage1432-
dc.citation.endPage1438-
dc.identifier.bibliographicCitationHEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, Vol.37(10) : 1432-1438, 2015-
dc.identifier.rimsid30541-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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