82 106

Cited 0 times in

Relationship between Myocardial Extracellular Space Expansion Estimated with Post-Contrast T1 Mapping MRI and Left Ventricular Remodeling and Neurohormonal Activation in Patients with Dilated Cardiomyopathy

 Ji Hyun Yoon  ;  Jung Woo Son  ;  Hyemoon Chung  ;  Chul Hwan Park  ;  Young Jin Kim  ;  Hyuk Jae Chang  ;  Geu Ru Hong  ;  Tae Hoon Kim  ;  Jong Won Ha  ;  Byoung Wook Choi  ;  Se Joong Rim  ;  Namsik Chung  ;  Eui Young Choi 
 Korean Journal of Radiology, Vol.16(5) : 1153-1162, 2015 
Journal Title
 Korean Journal of Radiology 
Issue Date
OBJECTIVE: Post-contrast T1 values are closely related to the degree of myocardial extracellular space expansion. We determined the relationship between post-contrast T1 values and left ventricular (LV) diastolic function, LV remodeling, and neurohormonal activation in patients with dilated cardiomyopathy (DCM). MATERIALS AND METHODS: Fifty-nine patients with DCM (mean age, 55 ± 15 years; 41 males and 18 females) who underwent both 1.5T magnetic resonance imaging and echocardiography were enrolled. The post-contrast 10-minute T1 value was generated from inversion time scout images obtained using the Look-Locker inversion recovery sequence and a curve-fitting algorithm. The T1 sample volume was obtained from three interventricular septal points, and the mean T1 value was used for analysis. The N-Terminal pro-B-type natriuretic peptide (NT-proBNP) level was measured in 40 patients. RESULTS: The mean LV ejection fraction was 24 ± 9% and the post-T1 value was 254.5 ± 46.4 ms. The post-contrast T1 value was significantly correlated with systolic longitudinal septal velocity (s'), peak late diastolic velocity of the mitral annulus (a'), the diastolic elastance index (Ed, [E/e']/stroke volume), LV mass/volume ratio, LV end-diastolic wall stress, and LV end-systolic wall stress. In a multivariate analysis without NT-proBNP, T1 values were independently correlated with Ed (β = -0.351, p = 0.016) and the LV mass/volume ratio (β = 0.495, p = 0.001). When NT-proBNP was used in the analysis, NT-proBNP was independently correlated with the T1 values (β = -0.339, p = 0.017). CONCLUSION: Post-contrast T1 is closely related to LV remodeling, diastolic function, and neurohormonal activation in patients with DCM.
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실)
Yonsei Authors
김영진(Kim, Young Jin) ; 김태훈(Kim, Tae Hoon) ; 박철환(Park, Chul Hwan) ; 손정우(Son, Jung Woo) ; 윤지현(Yoon, Ji Hyun) ; 임세중(Rim, Se Joong) ; 장혁재(Chang, Hyuck Jae) ; 정남식(Chung, Nam Sik) ; 정혜문(Chung, Hye Moon) ; 최병욱(Choi, Byoung Wook) ; 최의영(Choi, Eui Young) ; 하종원(Ha, Jong Won) ; 홍그루(Hong, Geu Ru)
사서에게 알리기
Files in This Item:
T201503500.pdf Download
RIS (EndNote)
XLS (Excel)


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.