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Relationship between Myocardial Extracellular Space Expansion Estimated with Post-Contrast T1 Mapping MRI and Left Ventricular Remodeling and Neurohormonal Activation in Patients with Dilated Cardiomyopathy

Authors
 Ji Hyun Yoon  ;  Jung Woo Son  ;  Hyemoon Chung  ;  Chul Hwan Park  ;  Young Jin Kim  ;  Hyuk Jae Chang  ;  Geu Ru Hong  ;  Tae Hoon Kim  ;  Jong Won Ha  ;  Byoung Wook Choi  ;  Se Joong Rim  ;  Namsik Chung  ;  Eui Young Choi 
Citation
 Korean Journal of Radiology, Vol.16(5) : 1153-1162, 2015 
Journal Title
 Korean Journal of Radiology 
ISSN
 1229-6929 
Issue Date
2015
Abstract
OBJECTIVE: Post-contrast T1 values are closely related to the degree of myocardial extracellular space expansion. We determined the relationship between post-contrast T1 values and left ventricular (LV) diastolic function, LV remodeling, and neurohormonal activation in patients with dilated cardiomyopathy (DCM). MATERIALS AND METHODS: Fifty-nine patients with DCM (mean age, 55 ± 15 years; 41 males and 18 females) who underwent both 1.5T magnetic resonance imaging and echocardiography were enrolled. The post-contrast 10-minute T1 value was generated from inversion time scout images obtained using the Look-Locker inversion recovery sequence and a curve-fitting algorithm. The T1 sample volume was obtained from three interventricular septal points, and the mean T1 value was used for analysis. The N-Terminal pro-B-type natriuretic peptide (NT-proBNP) level was measured in 40 patients. RESULTS: The mean LV ejection fraction was 24 ± 9% and the post-T1 value was 254.5 ± 46.4 ms. The post-contrast T1 value was significantly correlated with systolic longitudinal septal velocity (s'), peak late diastolic velocity of the mitral annulus (a'), the diastolic elastance index (Ed, [E/e']/stroke volume), LV mass/volume ratio, LV end-diastolic wall stress, and LV end-systolic wall stress. In a multivariate analysis without NT-proBNP, T1 values were independently correlated with Ed (β = -0.351, p = 0.016) and the LV mass/volume ratio (β = 0.495, p = 0.001). When NT-proBNP was used in the analysis, NT-proBNP was independently correlated with the T1 values (β = -0.339, p = 0.017). CONCLUSION: Post-contrast T1 is closely related to LV remodeling, diastolic function, and neurohormonal activation in patients with DCM.
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T201503500.pdf Download
DOI
10.3348/kjr.2015.16.5.1153
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
김영진(Kim, Young Jin) ORCID logo https://orcid.org/0000-0002-6235-6550
김태훈(Kim, Tae Hoon) ORCID logo https://orcid.org/0000-0003-3598-2529
박철환(Park, Chul Hwan) ORCID logo https://orcid.org/0000-0002-0004-9475
손정우(Son, Jung Woo)
윤지현(Yoon, Ji Hyun)
임세중(Rim, Se Joong) ORCID logo https://orcid.org/0000-0002-7631-5581
장혁재(Chang, Hyuck Jae) ORCID logo https://orcid.org/0000-0002-6139-7545
정남식(Chung, Nam Sik)
정혜문(Chung, Hye Moon)
최병욱(Choi, Byoung Wook) ORCID logo https://orcid.org/0000-0002-8873-5444
최의영(Choi, Eui Young) ORCID logo https://orcid.org/0000-0003-3732-0190
하종원(Ha, Jong Won) ORCID logo https://orcid.org/0000-0002-8260-2958
홍그루(Hong, Geu Ru) ORCID logo https://orcid.org/0000-0003-4981-3304
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/141128
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