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ROS-mediated bidirectional regulation of miRNA results in distinct pathologic heart conditions

 Seahyoung Lee  ;  Soyeon Lim  ;  Onju Ham  ;  Se-Yeon Lee  ;  Chang Yeon Lee  ;  Jun-Hee Park  ;  Jiyun Lee  ;  Hyang-Hee Seo  ;  Ina Yun  ;  Sun M. Han  ;  Min-Ji Cha  ;  Eunhyun Choi  ;  Ki-Chul Hwang 
 Biochemical and Biophysical Research Communications, Vol.465(3) : 349-355, 2015 
Journal Title
 Biochemical and Biophysical Research Communications 
Issue Date
Under distinct pathological heart conditions, the expression of a single miRNA can display completely opposite patterns. However, the mechanism underlying the bidirectional regulation of a single miRNA and the clinical implications of this regulation remain largely unknown. To address this issue, we examined the regulation of miR-1, one of the most abundant miRNAs in the heart, during cardiac hypertrophy and ischemia/reperfusion (I/R). Our data indicated that different magnitudes and chronicities of ROS levels in cardiomyocytes resulted in differential expression of miR-1, subsequently altering the expression of myocardin. In animal models, the administration of a miR-1 mimic attenuated cardiac hypertrophy by suppressing the transverse aortic constriction-induced increase in myocardin expression, whereas the administration of anti-miR-1 ameliorated I/R-induced cardiac apoptosis and deterioration of heart function. Our findings indicated that a pathologic stimulus such as ROS can bidirectionally alter the expression of miRNA to contribute to the development of pathological conditions exhibiting distinct phenotypes and that the meticulous adjustment of the pathological miRNA levels is required to improve clinical outcomes.
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5. Research Institutes (연구소) > Yonsei Integrative Research Institute for Cerebral & Cardiovascular Disease (뇌심혈관질환융합연구사업단) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Park, Jun-Hee(박준희)
Seo, Hyang Hee(서향희)
Lee, Se Yeon(이세연)
Lee, Chang Yeon(이창연)
Lim, So Yeon(임소연)
Ham, On Ju(함온주)
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