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ROS-mediated bidirectional regulation of miRNA results in distinct pathologic heart conditions

DC FieldValueLanguage
dc.contributor.author박준희-
dc.contributor.author서향희-
dc.contributor.author이세연-
dc.contributor.author이창연-
dc.contributor.author임소연-
dc.contributor.author함온주-
dc.date.accessioned2016-02-04T11:44:51Z-
dc.date.available2016-02-04T11:44:51Z-
dc.date.issued2015-
dc.identifier.issn0006-291X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/141109-
dc.description.abstractUnder distinct pathological heart conditions, the expression of a single miRNA can display completely opposite patterns. However, the mechanism underlying the bidirectional regulation of a single miRNA and the clinical implications of this regulation remain largely unknown. To address this issue, we examined the regulation of miR-1, one of the most abundant miRNAs in the heart, during cardiac hypertrophy and ischemia/reperfusion (I/R). Our data indicated that different magnitudes and chronicities of ROS levels in cardiomyocytes resulted in differential expression of miR-1, subsequently altering the expression of myocardin. In animal models, the administration of a miR-1 mimic attenuated cardiac hypertrophy by suppressing the transverse aortic constriction-induced increase in myocardin expression, whereas the administration of anti-miR-1 ameliorated I/R-induced cardiac apoptosis and deterioration of heart function. Our findings indicated that a pathologic stimulus such as ROS can bidirectionally alter the expression of miRNA to contribute to the development of pathological conditions exhibiting distinct phenotypes and that the meticulous adjustment of the pathological miRNA levels is required to improve clinical outcomes.-
dc.description.statementOfResponsibilityopen-
dc.format.extent349~355-
dc.relation.isPartOfBiochemical and Biophysical Research Communications-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleROS-mediated bidirectional regulation of miRNA results in distinct pathologic heart conditions-
dc.typeArticle-
dc.contributor.collegeResearcher Institutes (부설 연구소)-
dc.contributor.departmentYonsei Integrative Research Institute for Cerebral & Cardiovascular Disease (뇌심혈관질환융합연구사업단)-
dc.contributor.googleauthorSeahyoung Lee-
dc.contributor.googleauthorSoyeon Lim-
dc.contributor.googleauthorOnju Ham-
dc.contributor.googleauthorSe-Yeon Lee-
dc.contributor.googleauthorChang Yeon Lee-
dc.contributor.googleauthorJun-Hee Park-
dc.contributor.googleauthorJiyun Lee-
dc.contributor.googleauthorHyang-Hee Seo-
dc.contributor.googleauthorIna Yun-
dc.contributor.googleauthorSun M. Han-
dc.contributor.googleauthorMin-Ji Cha-
dc.contributor.googleauthorEunhyun Choi-
dc.contributor.googleauthorKi-Chul Hwang-
dc.identifier.doi10.1016/j.bbrc.2015.07.160-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01679-
dc.contributor.localIdA01921-
dc.contributor.localIdA02880-
dc.contributor.localIdA03244-
dc.contributor.localIdA04336-
dc.contributor.localIdA03373-1-
dc.relation.journalcodeJ00281-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0006291X15303892-
dc.contributor.alternativeNamePark, Jun-Hee-
dc.contributor.alternativeNameSeo, Hyang Hee-
dc.contributor.alternativeNameLee, Se Yeon-
dc.contributor.alternativeNameLee, Chang Yeon-
dc.contributor.alternativeNameLim, So Yeon-
dc.contributor.alternativeNameHam, On Ju-
dc.contributor.affiliatedAuthorPark, Jun-Hee-
dc.contributor.affiliatedAuthorSeo, Hyang Hee-
dc.contributor.affiliatedAuthorLee, Se Yeon-
dc.contributor.affiliatedAuthorLee, Chang Yeon-
dc.contributor.affiliatedAuthorHam, On Ju-
dc.contributor.affiliatedAuthorLim, So Yeon-
dc.rights.accessRightsnot free-
dc.citation.volume465-
dc.citation.number3-
dc.citation.startPage349-
dc.citation.endPage355-
dc.identifier.bibliographicCitationBiochemical and Biophysical Research Communications, Vol.465(3) : 349-355, 2015-
Appears in Collections:
1. Journal Papers (연구논문) > 5. Research Institutes (연구소) > Yonsei Integrative Research Institute for Cerebral & Cardiovascular Disease (뇌심혈관질환융합연구사업단)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원)

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