Cited 20 times in
ROS-mediated bidirectional regulation of miRNA results in distinct pathologic heart conditions
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박준희 | - |
dc.contributor.author | 서향희 | - |
dc.contributor.author | 이세연 | - |
dc.contributor.author | 이창연 | - |
dc.contributor.author | 임소연 | - |
dc.contributor.author | 함온주 | - |
dc.date.accessioned | 2016-02-04T11:44:51Z | - |
dc.date.available | 2016-02-04T11:44:51Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/141109 | - |
dc.description.abstract | Under distinct pathological heart conditions, the expression of a single miRNA can display completely opposite patterns. However, the mechanism underlying the bidirectional regulation of a single miRNA and the clinical implications of this regulation remain largely unknown. To address this issue, we examined the regulation of miR-1, one of the most abundant miRNAs in the heart, during cardiac hypertrophy and ischemia/reperfusion (I/R). Our data indicated that different magnitudes and chronicities of ROS levels in cardiomyocytes resulted in differential expression of miR-1, subsequently altering the expression of myocardin. In animal models, the administration of a miR-1 mimic attenuated cardiac hypertrophy by suppressing the transverse aortic constriction-induced increase in myocardin expression, whereas the administration of anti-miR-1 ameliorated I/R-induced cardiac apoptosis and deterioration of heart function. Our findings indicated that a pathologic stimulus such as ROS can bidirectionally alter the expression of miRNA to contribute to the development of pathological conditions exhibiting distinct phenotypes and that the meticulous adjustment of the pathological miRNA levels is required to improve clinical outcomes. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 349~355 | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Apoptosis | - |
dc.subject.MESH | Cardiomegaly/genetics | - |
dc.subject.MESH | Cardiomegaly/metabolism* | - |
dc.subject.MESH | Cells, Cultured | - |
dc.subject.MESH | Gene Expression Regulation/genetics | - |
dc.subject.MESH | Heart Failure/genetics | - |
dc.subject.MESH | Heart Failure/metabolism* | - |
dc.subject.MESH | MicroRNAs/genetics | - |
dc.subject.MESH | MicroRNAs/metabolism* | - |
dc.subject.MESH | Myocardium/metabolism* | - |
dc.subject.MESH | Nuclear Proteins/genetics | - |
dc.subject.MESH | Nuclear Proteins/metabolism* | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Reactive Oxygen Species/metabolism* | - |
dc.subject.MESH | Trans-Activators/genetics | - |
dc.subject.MESH | Trans-Activators/metabolism* | - |
dc.title | ROS-mediated bidirectional regulation of miRNA results in distinct pathologic heart conditions | - |
dc.type | Article | - |
dc.contributor.college | Researcher Institutes (부설 연구소) | - |
dc.contributor.department | Yonsei Integrative Research Institute for Cerebral & Cardiovascular Disease (뇌심혈관질환융합연구사업단) | - |
dc.contributor.googleauthor | Seahyoung Lee | - |
dc.contributor.googleauthor | Soyeon Lim | - |
dc.contributor.googleauthor | Onju Ham | - |
dc.contributor.googleauthor | Se-Yeon Lee | - |
dc.contributor.googleauthor | Chang Yeon Lee | - |
dc.contributor.googleauthor | Jun-Hee Park | - |
dc.contributor.googleauthor | Jiyun Lee | - |
dc.contributor.googleauthor | Hyang-Hee Seo | - |
dc.contributor.googleauthor | Ina Yun | - |
dc.contributor.googleauthor | Sun M. Han | - |
dc.contributor.googleauthor | Min-Ji Cha | - |
dc.contributor.googleauthor | Eunhyun Choi | - |
dc.contributor.googleauthor | Ki-Chul Hwang | - |
dc.identifier.doi | 10.1016/j.bbrc.2015.07.160 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01679 | - |
dc.contributor.localId | A01921 | - |
dc.contributor.localId | A02880 | - |
dc.contributor.localId | A03244 | - |
dc.contributor.localId | A04336 | - |
dc.contributor.localId | A03373-1 | - |
dc.relation.journalcode | J00281 | - |
dc.identifier.eissn | 1090-2104 | - |
dc.identifier.pmid | 26253469 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0006291X15303892 | - |
dc.subject.keyword | Heart | - |
dc.subject.keyword | ROS | - |
dc.subject.keyword | miRNA regulation | - |
dc.contributor.alternativeName | Park, Jun-Hee | - |
dc.contributor.alternativeName | Seo, Hyang Hee | - |
dc.contributor.alternativeName | Lee, Se Yeon | - |
dc.contributor.alternativeName | Lee, Chang Yeon | - |
dc.contributor.alternativeName | Lim, So Yeon | - |
dc.contributor.alternativeName | Ham, On Ju | - |
dc.contributor.affiliatedAuthor | Park, Jun-Hee | - |
dc.contributor.affiliatedAuthor | Seo, Hyang Hee | - |
dc.contributor.affiliatedAuthor | Lee, Se Yeon | - |
dc.contributor.affiliatedAuthor | Lee, Chang Yeon | - |
dc.contributor.affiliatedAuthor | Ham, On Ju | - |
dc.contributor.affiliatedAuthor | Lim, So Yeon | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 465 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 349 | - |
dc.citation.endPage | 355 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol.465(3) : 349-355, 2015 | - |
dc.identifier.rimsid | 64937 | - |
dc.type.rims | ART | - |
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